Might have fucked up my liquidex....

[Andy13]

I received 195mg of anastrolozole in the capsule mixed with l-tyrsosine (no fillers to my knowledge). I then dumped it in a glass which was added 40ml of 151 solution. I placed the glass on a frying pan and added medium heat. During the heating process I added about another 30 ml of 151 to compensate for the evaporation. Once cooled i aded 130ml of water to yield 190ml of 1mg/1ml solution with some powder still at the bottom. Is there no test that can be done to test the integrity of an anti-aromataser?

For the life of me I do not understand why guys insist on heating mixtures in order to dissolve them.. You cannot dissolve more drug by heating than by cool mixing...

Also, WHY was l-tyrosine added in the first place?

Anyway, with that said, there really is no reason why the tyrosine would reduce the solubility of the anastrolozole.. On the other hand, l-tyrosine isn't very soluble in water. Why don't you see if you can get some pure l-tyrosine powder from the health food store and compare relative solubility.. If you find pure l-tyrosine (perhaps in capsule form, check ingredients), and decide to go this route, I'll walk you though some simple experiments.

Andy

 

[Animal]

What physics rules your world?

Do you know the mp of ana?

'You cannot dissolve more drug by heating than by cool mixing...'

That is very scary.

An example is dbol in pg. Mix cool and it will never do a thing. Melt the dbol and then the stuff stays clear for all eternity.

You can most certainly get more solids into liquids by heating which is one of the elementary facts of chemisty!

 

[Andy13]

What physics rules your world?

Do you know the mp of ana?

'You cannot dissolve more drug by heating than by cool mixing...'

That is very scary.

An example is dbol in pg. Mix cool and it will never do a thing. Melt the dbol and then the stuff stays clear for all eternity.

You can most certainly get more solids into liquids by heating which is one of the elementary facts of chemisty!

Hey sport, what substance are we talking about here?

Man, you have some propensity for pissing off everyone...

 

[Animal]

Hey well, when you are categorically making and incorrect statement about a basic physical/chemical property I'm not too worried if you then get pissed off.

Basic chemical rule due to physics is that an increase in heat in a liquid enables the liquid to solvate more solids.

The only case where this doesn't apply is gas in a liquid where heat releases the gas, but then 151 and ana aren't gases.

In fact, you can dissolve just about anything in oil as it can be heated to 400F+, but then of course when it returns to room temp it will crystallize out.

The mistake somebody made was using 151 which has a LOW boiling point instead of using a ratio with BA which has a high bp.

 

[Animal]

Oh yea, and thanks for the name calling as that significantly added to the discussion and education of others as well as making you look extremelty intelligent in your doing so.

 

[Andy13]

Solubility increases with temperature (no joke ) but when temp is reduced, so is solubility. (This is very intuitive..)

Whether the solution is made a room temp or in boiling solvent, The END result is still "A solution with xmg/mL at 20C." Heating only accelerates the process, it does not premit more to dissolve.

For (yawn) completeness, I must add..

For the sake of the discussion, we can assume that a substance has some xmg/ml solubility at some temperature, and that is a constant... end of discussion... However, there are instances when when more mg/ml is "dissolved" than is supposed to be.. This phenomena (supersaturation) cannot be "counted" as deviating from the physical property of some chemical solid and its solubility in a solvent because it is not thought to be a solid dissolved, but a liquid that crystalizes out when seeded.

Enough--


L-dex is soluble in water up to 0.5mg/mL at room temp. It is more soluble in ethanol than water. Furthermore, it's solubility is independent of pH. L-tyrosine on the other hand has limited solubility in water, however its solubility INCREASES as pH decreases.

For your expt, 'if it doesn't dissolve in 151 @ 1mg/mL, we don't want it... It does not have to be filtered out.. But if you wish, you can collect some of the insoluble, and make a suspension in water. Add HCL and see if it dissolves..

Andy

 

[Nutrovitasub]

L-Tyrosine

L-Tyrosine is utilized for the synthesis of catecholamine neurotransmitters, such as norepinephrine, epinephrine and dopamine. JARROW FORMULAS’ L-TYROSINE is the pure, crystalline amino acid from biotech fermentation. It is NOT derived from milk.

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