mesotherapy

[theprofessor]

my step mom wants to do this, i have never heard of it before... anyone care to comment on it...
http://www.mesobody.com/

 

[jeepboi]

it works great, check out the plastic surgery section here, more info.

make sure that the dr. doesnt use pre filled, or pre mixed solutions.

make sure they mix it in the office.

the premixed concoction is bad news, since the ppc has a high ph, and some of the other ingredients are sensitive, expire in 30 days once mixed etc.....

so as long as you go to a reputable dr. then all is good, and she will love the results.

 

[theprofessor]

it works great, check out the plastic surgery section here, more info.

make sure that the dr. doesnt use pre filled, or pre mixed solutions.

make sure they mix it in the office.

the premixed concoction is bad news, since the ppc has a high ph, and some of the other ingredients are sensitive, expire in 30 days once mixed etc.....

so as long as you go to a reputable dr. then all is good, and she will love the results.

k+ thanks

 

[NYBodyguard]

lots of bodybuilders use it to even out bodyparts add size too read up

 

[macrophage69alpha]

the active ingredient is deoxycholate. its works like a DETERGENT. It causes cell lysis. This cell lysis is INDISCRIMINATE. Can kill both fat and muscle cells.

IMO it should be used with great care and long term effects have not been evaluated.

phosphatidyl choline does not have any activity of its own, it may augment delivery of the deoxycholate but that remains to be seen. (ie other bases tried)

 

[jeepboi]

the active ingredient is deoxycholate. its works like a DETERGENT. It causes cell lysis. This cell lysis is INDISCRIMINATE. Can kill both fat and muscle cells.

IMO it should be used with great care and long term effects have not been evaluated.

phosphatidyl choline does not have any activity of its own, it may augment delivery of the deoxycholate but that remains to be seen. (ie other bases tried)

thats why the PPC/DC phosphatidylcholine has deoxycholic acid in it. generally 5/4.2 or 10/8.4 BUT, Collegenase, Artichoke, Aminophyline, Some procaine, and somewhat new to meso is they are adding HGH to it.

Also it is injected into the derm layer, so you dont have necrosis etc...

 

[NYBodyguard]

the active ingredient is deoxycholate. its works like a DETERGENT. It causes cell lysis. This cell lysis is INDISCRIMINATE. Can kill both fat and muscle cells.

IMO it should be used with great care and long term effects have not been evaluated.

phosphatidyl choline does not have any activity of its own, it may augment delivery of the deoxycholate but that remains to be seen. (ie other bases tried)

there has to be a study out on this

 

[macrophage69alpha]

there has to be a study out on this

Dermatol Surg. 2006 Apr;32(4):465-80. Related Articles, Links


Mesotherapy and phosphatidylcholine injections: historical clarification and review.

Rotunda AM, Kolodney MS.

Department of Dermatology, University of Southern California School of Medicine, Los Angeles, California, USA. [email protected]

BACKGROUND: Mesotherapy was originally conceived in Europe as a method of utilizing cutaneous injections containing a mixture of compounds for the treatment of local medical and cosmetic conditions. Although mesotherapy was traditionally employed for pain relief, its cosmetic applications, particularly fat and cellulite removal, have recently received attention in the United States. Another treatment for localized fat reduction, which was popularized in Brazil and uses injections of phosphatidylcholine, has been erroneously considered synonymous with mesotherapy. Despite their attraction as purported "fat-dissolving" injections, the safety and efficacy of these novel cosmetic treatments remain ambiguous to most patients and physicians. OBJECTIVE: To distinguish mesotherapy from phosphatidylcholine injections by reviewing their history and the relevant experimental or clinical findings. METHODS: A comprehensive search of Medline indexed literature and conference proceedings. RESULTS: All the published studies evaluating the clinical efficacy of traditional mesotherapy currently originate from Europe. These reports focus primarily on musculoskeletal pain and vascular disease, rather than cosmetic applications. Although experimental data suggest that a number of traditional mesotherapy ingredients may theoretically reduce fat, these effects have not been supported in peer-reviewed studies. An increasing number of reports demonstrate that subcutaneous injections of a formula containing phosphatidylcholine combined with its emulsifier, deoxycholate, are effective in removing small collections of adipose tissue. Cell lysis, resulting from the detergent action of deoxycholate, may account for this clinical effect. CONCLUSIONS: Mesotherapy is distinct from a method of treating adipose tissue with subcutaneous injections of deoxycholate alone or in combination with phosphatidylcholine. Additional clinical and experimental studies are necessary to more definitively establish the safety and efficacy of these treatments.

Dermatol Surg. 2004 Jul;30(7):1001-8. Related Articles, Links


Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution.

Rotunda AM, Suzuki H, Moy RL, Kolodney MS.

Division of Dermatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA.

BACKGROUND: Phosphatidylcholine injections are becoming an increasingly popular technique to treat localized fat accumulation. This formula is composed primarily of phosphatidylcholine and sodium deoxycholate, a bile salt used to solubilize the natural phospholipid in water. The mechanism through which this injectable phosphatidylcholine formulation causes localized fat reduction is unknown. OBJECTIVE: To investigate the active component and mechanism of action of an injectable phosphatidylcholine formulation in clinical use. METHODS: Cell viability and cell membrane lysis assays were performed on cell cultures and porcine skin after treatment with the phosphatidylcholine formula, isolated sodium deoxycholate, or common laboratory detergents Triton-X 100 and Empigen BB. In addition, we described the histologic changes after injection of these substances into porcine tissue. RESULTS: A significant and comparable loss of cell viability, cell membrane lysis, and disruption of fat and muscle architecture was seen in cell cultures and tissue specimens treated with the phosphatidylcholine formula and isolated sodium deoxycholate. These findings were similar to the effects produced after treatment with laboratory detergents. CONCLUSIONS: The phosphatidylcholine formula popularly used in subcutaneous injections for fat dissolution works primarily as a detergent causing nonspecific lysis of cell membranes. Our findings suggest that sodium deoxycholate is the major active component responsible for cell lysis. Detergent substances may have a role in eliminating unwanted adipose tissue. It is advised that physicians use caution until adequate safety data are available.

 

[theprofessor]

k+ for all who chimed in...
i guess ill let my step mom sort through the info...

 

[macrophage69alpha]

its a relatively newer treatment, it does work but there are some concerns about its safety.

basically its injecting detergent into fat pockets to break down the cells, which die.