juggy54 said:
Hey guys i found this its a pretty good read.....they talk about testosterone injections for birth control...
http://www.msnbc.msn.com/id/3543478/
i read an article on it--test + duta
and before you ask, i have not heard of oral test en-th...apears to be a waste of a whole lot of test imho, but w/o the 17a, it's gone in less than 90 minutes (i think that is what i read)
Pharmacokinetics and Pharmacodynamics of Oral Testosterone Enanthate in Oil Plus Dutasteride for Four Weeks in Normal Men: Implications for Male Hormonal Contraception.
John K. Amory MD, MPH, Thomas F. Kalhorn PhD, Stephanie T. Page MD, PhD.
Center for Research in Reproduction and Contraception, Divisions of General Internal Medicine and Endocrinology, Metabolism and Nutrition, Department of Medicine and the Department of Medicinal Chemistry, University of Washington Medical School, Seattle, WA.
Context: Oral administration of testosterone enanthate (TE) and dutasteride, increases serum testosterone (T) in men and might be useful for male hormonal contraception.
Objective: We sought to ascertain the contraceptive utility of oral TE by determining the degree of gonadotropin suppression mediated by four weeks of oral TE in normal men.
Study Design, Setting Subjects and Intervention: Twenty healthy young men were randomly assigned to 4 weeks of either 400 mg oral TE twice daily or 800 mg oral TE once daily, in a double-blinded controlled fashion at a single site. All men received once daily dutasteride during treatment.
Outcome Measures: Blood for measurement of serum LH, FSH, T, DHT and estradiol was obtained prior to TE administration, weekly during treatment, and 1, 2, 4, 8, 12, 13, 14, 16, 20 and 24 hours after the morning dose on the last day of dosing .
Results: Serum testosterone levels were maintained during treatment, while estradiol increased somewhat and DHT was markedly suppressed in both dose groups. Median FSH was significantly suppressed throughout treatment with 800 mg TE once daily and after 4 weeks of treatment with 400 mg TE twice daily. Median LH was significantly suppressed after 2 weeks of treatment with 800 mg TE. HDL cholesterol was suppresed during treatment, but liver function tests, hematocrit, creatinine, mood and sexual function were unaffected.
Conclusions: The administration of 800 mg of oral TE daily combined with dutasteride for 28 days significantly suppresses gonadotropins without untoward side effects and might have utility as part of a male hormonal contraceptive regimen.
Key words: androgens, FSH, LH, 5a reductase, male contraception