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A
Animal
Guest
What happened to that thread as I want to read that study.
macrophage69alpha
New member
here let me help you. so as to forestall any further comments that you might make.
J Appl Physiol 2002 Sep;93(3):1168-80 Related Articles, Links
Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise.
Kimball SR, Farrell PA, Jefferson LS.
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Protein synthesis in skeletal muscle is modulated in response to a variety of stimuli. Two stimuli receiving a great deal of recent attention are increased amino acid availability and exercise. Both of these effectors stimulate protein synthesis in part through activation of translation initiation. However, the full response of translation initiation and protein synthesis to either effector is not observed in the absence of a minimal concentration of insulin. The combination of insulin and either increased amino acid availability or endurance exercise stimulates translation initiation and protein synthesis in part through activation of the ribosomal protein S6 protein kinase S6K1 as well as through enhanced association of eukaryotic initiation factor eIF4G with eIF4E, an event that promotes binding of mRNA to the ribosome. In contrast, insulin in combination with resistance exercise stimulates translation initiation and protein synthesis through enhanced activity of a guanine nucleotide exchange protein referred to as eIF2B. In both cases, the amount of insulin required for the effects is low, and a concentration of the hormone that approximates that observed in fasting animals is sufficient for maximal stimulation. This review summarizes the results of a number of recent studies that have helped to establish our present understanding of the interactions of insulin, amino acids, and exercise in the regulation of protein synthesis in skeletal muscle.
J Appl Physiol 2002 Sep;93(3):1168-80 Related Articles, Links
Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise.
Kimball SR, Farrell PA, Jefferson LS.
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Protein synthesis in skeletal muscle is modulated in response to a variety of stimuli. Two stimuli receiving a great deal of recent attention are increased amino acid availability and exercise. Both of these effectors stimulate protein synthesis in part through activation of translation initiation. However, the full response of translation initiation and protein synthesis to either effector is not observed in the absence of a minimal concentration of insulin. The combination of insulin and either increased amino acid availability or endurance exercise stimulates translation initiation and protein synthesis in part through activation of the ribosomal protein S6 protein kinase S6K1 as well as through enhanced association of eukaryotic initiation factor eIF4G with eIF4E, an event that promotes binding of mRNA to the ribosome. In contrast, insulin in combination with resistance exercise stimulates translation initiation and protein synthesis through enhanced activity of a guanine nucleotide exchange protein referred to as eIF2B. In both cases, the amount of insulin required for the effects is low, and a concentration of the hormone that approximates that observed in fasting animals is sufficient for maximal stimulation. This review summarizes the results of a number of recent studies that have helped to establish our present understanding of the interactions of insulin, amino acids, and exercise in the regulation of protein synthesis in skeletal muscle.
J
Juice Authority
Guest
Animal said:
It was closed since we weren't able to get along on that thread. You're an intelligent guy but some of your conclusions such as the ones on that insulin thread are wrong. Insulin does much more than just shuttle glucose as indicated in the findings I posted.
E
EF Anton
Guest
I'm saying this now, and I'm only saying it once: play nice, children. This is a discussion forum aimed at spread of information and sharing of new findings; if you start fighting like little kids, others (those that know less and desperately wish to learn) can and do suffer.
Bickering can be done over private messages and e-mail. Keep it off the boards.
Bickering can be done over private messages and e-mail. Keep it off the boards.
J
Juice Authority
Guest
EF Anton said:
It's all in good spirited fun. People actually tend to learn more from heated debates especially where animal is concerned but I hear what you're saying.
E
EF Anton
Guest
Juice Authority said:
Debates are very educational, and encouraged where a split of available information is concerned; fights aren't. I know that you understand the difference.
sh4dowf4lcon
New member
EF Anton said:
Debates are very educational, and encouraged where a split of available information is concerned; fights aren't. I know that you understand the difference.
Oh, he knows the difference alright. He is quite talented at keyboard battle. lol !!
between animal and JA they are itching to scratch non stop.
lol asstards
Goldprospector
New member
Sure would be nice if this applied all of the time...especially to the ones who start most all of the BS.
J
Juice Authority
Guest
sh4dowf4lcon said:
Only when the point I'm trying to make falls on deaf ears. hint hint.
A
Animal
Guest
I asked a simple question and people start bitching! There's your freakin problem around here.
Fuck this thread and close the fucker as I'm not participating in all this bullshit bitching which has nothing to do about the thread. Put it in the pissass chat area.
Some chump mod starts right off with a smartass comment AS USUAL around this hole and doesn't even post the full study which I now have.
Enjoy the bitching.
Fuck this thread and close the fucker as I'm not participating in all this bullshit bitching which has nothing to do about the thread. Put it in the pissass chat area.
Some chump mod starts right off with a smartass comment AS USUAL around this hole and doesn't even post the full study which I now have.
Enjoy the bitching.
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