Is this Primo beneficial at all?

[Agent Dana Scully]

http://www.a1supplements.com/images...W_A1_113405.JPG


Primobolan, 60 tabs




Primobolan® oral tablets contain 100 mg of the chemically described as 4-Androsten-4-ol -3beta ,17beta-dione Acetate an irreversible, steroidal aromatase inhibitor.

Chemical Structure Its molecular formula is C21 H28-04

The active ingredient is a white crystalline powder with a molecular weight of 344.4
Each Tablet contains the following:

Inactive ingredients: Magnesium Carbonate, Microcrystalline Cellulose, Pregelatinized Starch, Stearic Acid, Magnesium Stearate, and Croscramellose Sodium.

CLINICAL PHARMACOLOGY

The chemical term 4-Androstenoldione Acetate refers to the isomer: 4-Androsten-4-ol-3beta,17beta-dione Acetate. 4-Androstenoldione Acetate is the acetate ester derivative of 4-Hydroxy-4-Androstenedione, which is an analog or derivative of the naturally occurring precursor hormone 4-Androstenedione. 1 This compound concerns the isomer form of 4Androsten-4-ol-3beta,17beta-dione Acetate.

4-Androstenoldione Acetate is a steroidal aromatase inhibitor that inhibits estrogen biosynthesis, increases natural production of total and free testosterone, and may inhibit DHT formation. It does this by inhibiting the Cytochrone P-450 enzyme, which converts testosterone to estrogen. Once estrogen levels fall a signal is sent to the hypothalamic pituitary axis to produce (LH) luteinizing hormone and decrease (SHBG) steroid hormone binding globulin. 2 ,3 LH then stimulates the testes to increase total testosterone production, in which a large portion is free or active testosterone due to the decrease in SHBG. This increased amount of testosterone is then metabolized with less estrogen and DHT conversion.4

Metabolic Actions

Compounds in this class also may cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein. Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor.

Pharmacokinetics

The compound is mainly eliminated by metabolism, renal excretion of metabolites accounting for 95% of dose. The excretory balance of 14C-compounds in urine and feces totals up to 98.9+/-0.8% of the i.v. dose after 168 h. The 14C-compounds in plasma and urine were separated by HPLC, and three major metabolites were submitted to structural analysis by MS, NMR and UV spectroscopy. One of the metabolites is the direct 4-O-glucuronide of formestane. The other two represent 3-O-sulfates of the exocons 3beta,4beta-dihydroxy-5alpha-androstane-17-one and 3alpha,4beta-dihydroxy-5alpha-androstane-17-one, their ratio being 7:3. These exocons are formed by stereoselective 3-keto reduction, accompanied by reduction of the 4,5-enol function. The exocons do not inhibit human placental aromatase activity in vitro. 5

The half-life orally was approximately 3 h, whereas the apparent half-life of injected drug was between 5 and 10 days after a more rapid clearance during the first 4 days after injection. The formulated material achieved a significantly higher mean peak concentration (88% greater than that obtained using the unformulated powder) and a higher mean AUC (not significant). The median time to peak was 1.5 h for both preparations and the elimination rate constants were similar (0.31 for micronized 4-OHA and 0.36 h-1 for formulated 4-OHA). Significant biological activity was demonstrated with the formulated material in its suppression of plasma oestradiol levels. 6

Efficacy Studies

Subcutaneous treatment of immature male rats with an estrogen precursor, 19-hydroxy-testosterone (19-OHT), at a daily dose of 1 mg/animal for 14 days leads to a significant decrease in the weight of testis, ventral prostate and seminal vesicle. The peripheral levels of LH are lowered. Testicular histology indicates that the effects of 19-OHT are very similar to the known of effect induced by estradiol-17 beta. 19OHT induces a marked impairment of spermato and spermiogenesis. The maturation division is completely inhibited. The effect of 19-OHT on spermatogenesis is partially reversed by concomitant administration of an aromatase inhibitor (4-acetoxy-4-androstene-3.17-dione, (4-AA] at a dose of 1 mg/animal/day s.c. Meiotic activity is restored, and the weights of genital organs and the serum LH values increase. 4-AA alone has no appreciable effect on the parameters examined in this study. The present results suggest that specific inhibitors of estrogen biosynthesis might not only be useful to investigate the patho-physiological role of estrogens on spermatogenesis. 7

Clinical Studies

Another interesting note is the ability of 4-Androsten-4-ol-3, 17-dione acetate to directly stimulate testosterone whether in the presence of LH or not. Researchers examined the effects of placebo, luteinizing hormone (LH), 4-acetoxy-4-androstenedione, and luteinizing hormone (LH) plus 4-acetoxy-4-androstenedione on rat follicles in vitro. In regards to testosterone they found that within the first 8 hours 4-acetoxy-4-androstenedione had the ability to directly stimulate testosterone alone and greatly stimulate testosterone in combination with luteinizing hormone (LH). Interestingly enough within the next 16 hours they discovered 4-acetoxy-4-androstenedione alone was stimulating testosterone 3 times as much as luteinizing hormone (LH) while the combination also continued to stimulate testosterone

Shop our 100% secure server and get your supplements at the lowest prices everyday! NOBODY beats our overall price.


???


http://www.a1supplements.com/detail.aspx?id=51

???

 

[buffsthestuff]

dont waste your money

 

[bigtravis]

My Advise Is Edit. Radar Has Already Corrected This Once On The Gear Pics Forum. So You Know Already Not To Do It Here.

 

[Agent Dana Scully]

It is editted, the price is not mentioned. he said its useless cuz its in pill form, i just wanted to see what others thought about this. Cuz i really don't want to use a needle.

 

[bilter]

needles are cool!! stick! poke! stick! poke!

 

[Agent Dana Scully]

And it seems to be the same price in every site i go to, and they all say the same thing, that it decreases estrogen and DHT ( i guess good for balding ) produces natural testosterone, that it should be used by weekend athletes, or by people who just got off a cycle.

I was wondering if it would be beneficial to me, since im not trying to get huge, but i just want to increase strength significantly in just certain areas of my body (forearms, back) for bouldering/climbing.

besides, i wouldn't think there would be a problem posting this stuff up, cuz according to these sites, this shit is legal (???).

 

[Agent Dana Scully]

Oh, btw, the reason im posting this here is because i know i'll get more responses than just plain ol' " don't waste your money!" I want to know the why. I'm new to this, so i need opposing arguments to decide for myself. I need to know why i shouldn't waste my money, why it doesn't work, cuz i'm reading about this, and it sounds really convincing:

What if I was to tell you that I know of a compound that can dramatically increase natural production of total and free testosterone while simultaneously inhibiting estrogen and DHT formation? Dare I say a good for you steroid? Lets see, a steroid that has all of the positive strength and muscle building effects of

testosterone but none of the negative side effects associated with androgen metabolites. Sounds too good to be true, right? Wrong!! Now while some steroids and pro-steroids are designed to produce less estrogen and DHT, they still do and can produce significant amounts of estrogen if taken in excess. This new compound raises testosterone by decreasing estrogen levels and longer you take it the better it works. This is truly the next great breakthrough in legal supplemental hormones.

This might sound somewhat similar to an old concept once described by Dan Duchaine with a little well known compound Flavone X (Chrysin). Although, Chrysin (plant aromatase) never panned out because it had almost zero oral bioavailability and was only a mild aromatase inhibitor. To be honest this is probably a bad example since Chrysin doesnt even come close in action to this new compound. Chrysin was thought to only shift the estrogen testosterone ratio slightly in favor of testosterone. This new compound dramatically inhibits estrogen formation and also stimulates the production of total and free testosterone, not just shifting the ratio.


http://www.nicemuscle.com/primobolan-80710.htm

Anyone want to debunk this, please?

 

[Agent Dana Scully]

more:

People who can Benefit



Who can benefit from this product? Well the main groups of individuals who will benefit the most are 1) anyone using prohormones, 2) anyone using steroids, and 3) anyone who doesnt use prohormones or steroids. Did I miss anyone? Anyway, people using this new compound in conjunction with prohormones would receive much greater benefits, as compared to using prohormones by themselves, due to the increase in natural testosterone production coupled with the synthetic conversion of the prohormone. There would then be no concern over estrogen accumulation resulting in harder gains. As a result, natural testosterone production would not shut off. Lastly it has been shown that this compound has the ability to increase the amount of liver enzyme responsible for the conversion of prohormones. 6 This means you get a greater amount of testosterone or nor-testosterone prohormone conversion resulting in greater gains. Steroid users would receive the same benefits but on a somewhat larger scale since, side effects are more prevalent with actual steroids. So the anabolic pharmaceutical user could take this in an attempt to prevent testicular shut down, prevent an accumulation of estrogen, inhibit DHT formation, and to solidify any gains from the steroids due to no hormonal drop in natural testosterone after the cycle.



The non-prohormone or non-steroid user can also receive great benefits from this compound. The inhibition of estrogen formation and the stimulation of total and free testosterone can impart extensive physique altering benefits. This hormonal alteration can promote solid gains in muscle mass and strength. The inhibition of estrogen biosynthesis would provide a decrease in excess extra cellular water and promote a better environment for fat burning. The stimulation of total and free testosterone promotes muscle mass, strength, and recovery. This is due to the fact that testosterone output is now greater with a higher free or active portion of testosterone.



this shit sounds great....

 

[buffsthestuff]

if its legal there is no way that it is actually primo and of course the company trying to sell you the product is gonna make it look great it sounds like you have made your mind up already but your just seting yourself up for disapointment with the product and less cash in your pocket

 

[danasti]

Sure, I'll debunk it.

1.
Read the "reviews" - The fifth one down states his bench went from 285lb to 500lb! In a month? From taking what THEY (THE COMPANY ITSELF) claims is an aromatase inhibitor. Everybody can just move straight to pct for the real gains then.

http://www.nicemuscle.com/primobolan-80710.htm

Anyone want to debunk this, please?

2.
It's not primobolan!
primobolan IS methenolone acetate (or 17 beta-hydroxy-1-methyl-5 alpha-androst-1-en-3-one) and is not (4-Androsten-4-ol-3beta,17beta-dione Acetate)

If it could double your max bench - especially a 285lb bench! - Then why in the world would it fraudulently hide behind a clearly inferior ACTUAL steroid??!
Going from a 285lb bench to a 320 lb bench, in one month, on the steroid primobolan would be conisidered a pretty damn good month.

Is that enough debunking? I sense the placebo/holy grail effect is stong with you.

3.
Anyone can (and they do) take a pill machine, chemically fuck with basically anything and call it (5 alpha beta - 1 androsen - 3 methyl - bs) then brand it as a "supplement" - the fda doesn't regulate or care... hmmm... just like this very suspicious product. Welcome to the supplement industry.

The reason not many people will respond to you is because someone is always posting about some miracle pill - super supplement, copying and pasting all the companies bullshit marketing material. I'm not flaming you but I'm telling you why people ignore the post and the product entirely - they just figure you'll either learn or go away.

4.
You're just going to take what you want and believe what you want and spend your money where you want. You can go over to the supplement board and find posts where guys say their livers hurt from "cycling" tribus - or they got bad back acne from their fruit punch flavored No2 and there's always some new pill that doubles muscle and streghth in weeks without any side effects and it has just been discovered or has been completely overlooked. It's a business that's based on belief and the condition known as the placebo effect.

If you really want to gain strength then lift and eat food.