Is it possible to restore the HTPA with Nolvadex?

[nydj66]

According to swale HCG can itself be inhibitory of HPTA and can cause insensitivity to LH.

Therefore, in the BB world it is best used in one of two fashions; taking periodically during a cycle to maintain testicular form and function. Or, taken during the last 2 weeks of a cycle to restore testicular form and function in preparation for PCT.

Once PCT begins, Nolvadex, clomid or a combination of the two is used to stimulate LH production. Using HCG at this point would temporarily increase testosterone output but prolong suppression.

 

[adam wj]

why DON'T you want to use hcg?

do you not like shots or are you just curious?
for me too, hcg is a must. i had bloodwork done after a light cycle and clomid only pct and my test was 378. after "proper" pct (hcg 1000iu mwf 3 wks along with novla through 5) my test levels are now 828. my LH was in the high range of normal, so i have a little time before i'm completely leveled out but i'll say that the hcg/novla combo was completely worth it. if you have access to novla, you have access to hcg. get it. if youre worried about LH receptors getting downregulated, dont take excessive doses for long peroids of time.

 

[gregory]

why DON'T you want to use hcg?

do you not like shots or are you just curious?
for me too, hcg is a must. i had bloodwork done after a light cycle and clomid only pct and my test was 378. after "proper" pct (hcg 1000iu mwf 3 wks along with novla through 5) my test levels are now 828. my LH was in the high range of normal, so i have a little time before i'm completely leveled out but i'll say that the hcg/novla combo was completely worth it. if you have access to novla, you have access to hcg. get it. if youre worried about LH receptors getting downregulated, dont take excessive doses for long peroids of time.

Was the second blood test done 2 months after the "REAL" pct? Because if not, then you got yourself a fake reading. A test like this has to be done about 8 weeks post your PCT, then you see the real deal. Any sooner and you're still riding the pct wave baby!!

 

[adam wj]

greg neither test was more than two months after, still riding the pct wave at 378 is pretty shitty

 

[junk]

No.

Both Nolvadex and Clomid increase pituitary LH secretion by blocking negative feedback on the HPTA.

The action of HCG is indentical to that of pituitary LH. HCG will cause an immediate increase in testosterone production, testicular volume and spermatogenesis. It's obviously strong enough to cause gynecomastia.

Use a combination of all 3 if you are concerned.

Jenetic

Excellent sound advice. Never understood why people would risk their recovery. Like Jenetic said, a good sensible combination of all three with a well planned dosing regimn is the key.


JUNK

 

[heavyweightBoxer]

Well, I thought the main focus with HCG is to restore the normal ability of the testes to respond to endogenous luteinizing hormone.

I'll probably start with 1500-3000 I.U. every 5th day, for a 2 week duration whilst using Nolva at the same time- is this a good idea?

 

[BIG SMT]

According to swale HCG can itself be inhibitory of HPTA and can cause insensitivity to LH.

Therefore, in the BB world it is best used in one of two fashions; taking periodically during a cycle to maintain testicular form and function. Or, taken during the last 2 weeks of a cycle to restore testicular form and function in preparation for PCT.

Once PCT begins, Nolvadex, clomid or a combination of the two is used to stimulate LH production. Using HCG at this point would temporarily increase testosterone output but prolong suppression.

Exactly what I was going to say about HCG. It is for testicular atrophy, not HPTA regeneration.

Nolva will help restore HPTA, but not as fast as clomid.


Tamox vs Clomid

Am J Physiol 1983 Feb;240(2):E125-30

Disparate effect of clomiphene and tamoxifen on pituitary gonadotropin release in vitro.

Adashi EY, Hsueh AJ, Bambino TH, Yen SS.

The direct effects of clomiphene citrate (Clomid), tamoxifen, and estradiol (E2) on the gonadotropin-releasing hormone (GnRH)-stimulated release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were studied in cultured anterior pituitary cells obtained from adult ovariectomized rats. Treatment of pituitary cells with Clomid or enclomid (10(-8) M) in vitro for 2 days resulted in a marked sensitization of the gonadotroph to GnRH as reflected by a 6.5-fold decrease in the ED50 of GnRH in terms of LH release from 2.2 x 10(-9) M in untreated cells to 3.6 x 10(-10) M. Treatment with E2 or Clomid also increased the sensitivity of the gonadotroph to GnRH in terms of FSH release by 4.3- and 3.3-fold respectively. Tamoxifen, a related antiestrogen, comparable to Clomid in terms of its ability to compete with E2 for pituitary estrogen receptors, was without effect on the GnRH-stimulated LH release at a concentration of 10(-7) M. Furthermore, tamoxifen, unlike Clomid, caused an apparent but not statistically significant inhibition of the sensitizing effect of E2 on the GnRH-stimulated release of LH. Our findings suggest that Clomid and its Enclomid isomer, unlike tamoxifen, exert a direct estrogenic rather than an antiestrogenic effect on cultured pituitary cells by enhancing the GnRH-stimulated release of gonadotropin.

 

[Slyder190]

I use both HCG and Nolvadex as I am on HRT.

HRT? How old are you and what's your history?

 

[Jenetic]

I'm not cycling anything as of now, I just want to increase (restore) my test levels.

A close relative of mine died 5 months ago and I havent been the same since, it has undoubtedly affected my test level and motivation to workout, not to mention my sex drive is at an all time low.

Sorry to hear that. Do you have blood work that shows a significant decline in your testosterone levels? It's quite possible that you are simply depressed.

Jenetic

 

[georgie24]

so hcg is no good post cycle? this shit is too confusing