Is Estrogen the cause for men or females being fat?

[Counterstrike]

I mean does i cause likus males to have a belly or love handles flabby? I thought i read somewhere it stated estrogen keeps fat around or some shit. seen post here when females taken liquidex lost BF big times curious how this works. if i did clen and liquidex and ofcourse clean diet does that mean i'll drop BF big time?

 

[supertech69]

Hmmm, if this is the case, what would the affect be of a woman simply taking say, nolvadex? Wouldn't it work as a fat loss supp?

 

[Counterstrike]

Hmmm, if this is the case, what would the affect be of a woman simply taking say, nolvadex? Wouldn't it work as a fat loss supp?

Not sure but there was a post or two about this guy giving his girl liquidex and she shedded alot of B i was thinking of using low dose for a few weeks along with clen to see whathappens

 

[macrophage69alpha]

NOLVADEX has been shown to INCREASE ADIPOSITY IN WOMEN..

why is not known.. may be due to A2 Agonism (it is a SERM) or due to another mechanism (likely an E realted one though)

 

[nandi12]

My understanding is that tamoxifen, being an antiestrogen, changes the distribution of fat. Women keep fat preferentially in the femoral-gluteal region (butt and thighs); men deposit it abdominally and viscerally (gut and around the organs). The former is hard to mobilize because gluteal-femoral fat has high lipoprotein lipase activity. This is thought to be a storage mechanism for women to hold fat during times of food deprivation in order to have adequate fat for nursing.

The abdominal and visceral fat in men has a low lipoprotein lipase activity so it is easily mobilized. Again, evolutionarily this is supposed to have helped primative man mobilize fat for energy in fight or flight situations.

When women are given nolvadex the fat deposition changes more to that of a man. Becuase the resulting visceral fat is readily mobilized, unless a woman watches her diet the free fatty acids can flood the circulation and end up being redeposited all over as fat. Women are actually better off having their fat locked away in their hips. The so called pear shape is much less prone to heart disease because the fat cannot enter the bloodstream and clog the arteries.

 

[macrophage69alpha]

Nandi,

tamox=SERM

and the E affects on A2 are not hormonal(ER) (at least the direct effects.. as there is direct A2 binding)..

the studies showed knwon change in pattern (or it was not noted) but did show INCREASED adiposity.. reflecting anti-lypolytic effects.. likely A2 related...

 

[nandi12]

There are several studies of which I am aware that show a change in fat distribution. One abstract is reproduced below. I am aware that nolvadex is a serm. Evidently its effects are antiestrogenic in adipose tissue. ( as you know, a serm shows estrogenic efects in some tissue, antiestrogenic in others)

Int J Obes Relat Metab Disord 2001 Feb;25(2):296-8

Relationships between tamoxifen use, liver fat and body fat distribution in women with breast cancer.

Nguyen MC, Stewart RB, Banerji MA, Gordon DH, Kral JG.

Department of Surgery, SUNY Downstate Medical Center, Brooklyn, New York 11203-2098, USA.

Tamoxifen is a nonsteroidal anti-estrogenic drug used for adjuvant treatment of breast cancer and recently as a chemopreventative agent for breast cancer and, on an investigational basis, for other cancers. To date there are case reports of hypertriglyceridemia and fatty liver disease in tamoxifen users. Fatty liver is associated with visceral obesity and other components of the metabolic syndrome. Here we evaluated steatosis and adipose tissue distribution by CT scan in a cross-sectional study of 32 women on tamoxifen and 39 control women. Tamoxifen users had more visceral adipose tissue (VAT) and more liver fat than controls. This is the first study to demonstrate that fatty liver and intra-abdominal fat accumulation are common in breast cancer patients receiving tamoxifen. Prospective studies of tamoxifen should monitor metabolic changes in obese women with or without breast cancer.

 

[macrophage69alpha]

NANDI,

can see the point there.. but it would be more likely that that is due to the insulin sensitivity changes from using tamox (that being a Hormonal effect) and agree that would affect LPL levels..

the effects on A2 are NOT hormonal.. direct receptor binding.. cant say what the activity is.. but studies show an increase in TOTAL BODY FAT with tamox use.. (which may be due to a combination of the Insulin effects and the A2 binding).. but then again could be completely off

 

[nandi12]

It took me a minute to find this in my files, Macrophage, but it is a study you might enjoy reading. It looks at the change in fat distribution in female to male transsexuals. Testosterone given to the women changes the fat distribution from female to largely that of a male (from hip and thigh to visceral).

http://jcem.endojournals.org/cgi/content/full/82/7/2044

Alpha 2 adrenoreceptor effects have peen postulated to influence the sexual dimorphism of fat distribution, but I'm sure the picture is more complex than simple alpha 2 control. People don't know how the sex hormones actually determine adiposity. Regarding tamoxifen, it has been shown to inhibit lipoprotein lipase activity. This could explain how it counteracts the increased LPL activity due to estrogen. This is what I was referring to when I said that tamoxifen was antiestrogenic in fat: it decreases LPL whereas estrogen increases LPL. The high LPL activity in the gluteal-femoral region, probably due to estrogen, at least in part, is what makes that fat hard to burn. The nolvadex should make that fat easier to mobilize.

 

[macrophage69alpha]

Nandi..

that pretty much confirms the above postulations that E is responsible for maintaining (whether direct binding or indirect hormonal regulation of ) A2 dense fat.. thus the complete absence of E (by ovariectomy) except through aromatization.. over time and in the presence of androgen.. you will get a androgenic fat pattern..

agree that the other study shows that tamox will give more "andro fat".. but seems unclear whether it will affect A2 fat.. there are no indications that it does..