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Is acetomenophen (Tylenol) an NSAID?

Lumberg

New member
Just wondering. Since NSAIDS inhibit prostaglandin synthesis and therefore muscle repair thinking that acetomenophen might be the way to go for pain killing.

JC
 
I think it is. It lowers fever, relieves pain, and reduces inflammation. That would make it a NSAID.
Why do you think it´s the way to go? You say it inhibits muscle repair, which doesn´t seem like a good thing to me.
 
I'm pretty sure it is a separate class of drug. I don't think it reduces swelling. Just a fever reducer/analgesic.
 
joncrane said:
Does anyone know if it inhibits prostaglandins?

non-steroidal anti-inflammatory
<pharmacology> A large group of anti-inflammatory agents that work by inhibiting the production of prostaglandins. They exert anti-inflammatory, analgesic and antipyretic actions.

Examples include: ibuprofen, ketoprofen, piroxicam, naproxen, sulindac, aspirin, choline subsalicylate, diflunisal, fenoprofen, indomethacin, meclofenamate, salsalate, tolmetin and magnesium salicylate.

A contrast is made with steroidal compounds (such as hydrocortisone or prednisone) exerting anti-inflammatory activity.


Acetaminophen (tylenol) is not a NSAID.
 
Am J Physiol Endocrinol Metab 2002 Mar;282(3):E551-6

Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis.

Trappe TA, White F, Lambert CP, Cesar D, Hellerstein M, Evans WJ.

Donald W. Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, and the Central Arkansas Veterans HealthCare System, Little Rock, Arkansas 72205, USA. [email protected]

We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness after high-intensity eccentric resistance exercise. Twenty-four males (25 +/- 3 yr, 180 +/- 6 cm, 81 +/- 6 kg, and 17 +/- 8% body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1,200 mg/day), acetaminophen (ACET; 4,000 mg/day), or a placebo (PLA) after 10-14 sets of 10 eccentric repetitions at 120% of concentric one-repetition maximum with the knee extensors. Postexercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 +/- 19% (P < 0.05) in PLA (0.058 +/- 0.012%/h) and was unchanged (P > 0.05) in IBU (35 +/- 21%; 0.021 +/- 0.014%/h) and ACET (22 +/- 23%; 0.010 +/- 0.019%/h). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase, or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise. Thus these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle.
 
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