Interpreting an article by Brock Strasser.

[CYCLEON]

while i dont agree that there might be a disproportionately larger amount of receptor cite density in gluteal muscles per say - but because of the the size of the glutes - it could be that as a larger muscle the glutes allow the injection to disperse more quickly and get to the receptors - of which there are a lot more available in within the immediate area of the injection.

 

[Hugh Gellatts]

"while i dont agree that there might be a disproportionately larger amount of receptor cite density in gluteal muscles per say - but because of the the size of the glutes - it could be that as a larger muscle the glutes allow the injection to disperse more quickly and get to the receptors - of which there are a lot more available in within the immediate area of the injection."

I can understand this in the case of suspension... but esterified steroids cannot bind untill they are broken down into the parent compound.... i.e, the steroid will be out of the muscle and in the blood by the time it is released from the ester.

 

[panerai]

http://anabolicfitness.infopop.net/2/OpenTopic?a=tpc&s=702093973&f=312093973&m=5760961042#2040915042

 

[CYCLEON]

I can understand this in the case of suspension... but esterified steroids cannot bind untill they are broken down into the parent compound.... i.e, the steroid will be out of the muscle and in the blood by the time it is released from the ester.

im quite aware of that - well, that could be why he says that the short esters have more pop - in effect the compound de-esterfying more quickly has a combinatory beneficial effect with a wide area dispersment on raising blood plasma levels - rather than a low concentration/slower dispersment/smaller area.

now Im not saying I have come to the final conclusion that this argument is gospel but it does seem to have a logical basis.

 

[CYCLEON]

thanks panerii - for those who arent AF members


Pharmacokinetics and pharmacodynamics of nandrolone esters in oil vehicle: effects of ester, injection site and injection volume.

J Pharmacol Exp Ther 1997 Apr;281(1):93-102 (ISSN: 0022-3565)

Minto CF; Howe C; Wishart S; Conway AJ; Handelsman DJ [Find other articles with these Authors]
Department of Anaesthesia and Pain Management, Royal North Shore Hospital, University of Sydney, Australia.

We studied healthy men who underwent blood sampling for plasma nandrolone, testosterone and inhibin measurements before and for 32 days after a single i.m. injection of 100 mg of nandrolone ester in arachis oil. Twenty-three men were randomized into groups receiving nandrolone phenylpropionate (group 1, n = 7) or nandrolone decanoate (group 2, n = 6) injected into the gluteal muscle in 4 ml of arachis oil vehicle or nandrolone decanoate in 1 ml of arachis oil vehicle injected into either the gluteal (group 3, n = 5) or deltoid (group 4, n = 5) muscles. Plasma nandrolone, testosterone and inhibin concentrations were analyzed by a mixed-effects indirect response model. Plasma nandrolone concentrations were influenced (P < .001) by different esters and injection sites, with higher and earlier peaks with the phenylpropionate ester, compared with the decanoate ester. After nandrolone decanoate injection, the highest bioavailability and peak nandrolone levels were observed with the 1-ml gluteal injection. Plasma testosterone concentrations were also influenced (P < .001) by the ester and injection site, with the most rapid, but briefest, suppression being due to the phenylpropionate ester, whereas the most sustained suppression was achieved with the 1-ml gluteal injection. Plasma inhibin concentrations were also significantly influenced by injection volume and site, with the lowest nadir occurring after the nandrolone decanoate 1-ml gluteal injection. Thus, the bioavailability and physiological effects of a nandrolone ester in an oil vehicle are greatest when the ester is injected in a small (1 ml vs. 4 ml) volume and into the gluteal vs. deltoid muscle. We conclude that the side-chain ester and the injection site and volume influence the pharmacokinetics and pharmacodynamics of nandrolone esters in an oil vehicle in men.

 

[John Woe]

The injections in the glutes surprises me. And is this really enough data to claim these interpatations.

 

[liftsiron]

Another very good and interesting post Andy the glute site if it is true is a surprise to me, but it may be true for some of the reasons stated above.???

 

[Andy13]

I have no clue.. I can only guess that b/c of the circulation and the activity of the glute that it causes the steroid to enter the blood and be de-esterified at a greater rate... but i don't know..

Brock makes it out to be that if you don't use shorter esters and don't inject in your glutes that you will lose something.. Well, where does the AAS go??

All of his observations regarding concnetration and ester length of the steroid are valid for this one time injection... But all will even out in the long run compared to a longer ester and less concentrated steroid.

I was all excited in the beginning of his article where he says "sit back and prepare to be educated..." but was kind of disapointed once i analized his article.


My conclusion? This article says nothing... Or maybe I'm just too stupid to get it (which may very well be a possibility).. After all, I dont have a BS in biochemistry like fonz does.. Maybe he'll come through here and educate us...

Andy

 

[liftsiron]

I have to agree with you, the article is inconclusive. You can't just lose mg's of steroid either, perhaps for some reason glute injections get to the blood stream faster, although I would have thought that shoulder injections would be faster. As far as esters I agree that in the end, results in the long run will be similiar regardless of esters, we see that all the time.

 

[musclebrains]

I enjoy Strasser's articles but a lot of times they seem to be more speculation than fact, more anecdotal than medical. As I recall, for example, he is an advocate of using clomid throughout cycles, compared to nearly every objective argument against the practice. I've learned to take everything he writes skeptically.