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How many different steroids can one make from 1-test....

Spidey

New member
This thread is strictly for entertainment purposes. I do not use or condone the use of illegal drugs. I have not performed these syntheses, nor will I consider doing so.


BOLDENONE CYPIONATE (fast acting EQ)

Step 1: 1-Test cyp is brominated in the 4 position with 2,4,4,6-tetrabromocyclohexa-2,5-dione in ether with catalytic HCl. The product is 4-bromo-1-testosterone cypionate. There are other methods to achieve this bromination as well but this one should work very cleanly with a minimum of side reactions.

Step 2: the bromide is eliminated to give the 4,5-double bond by stirring the above product in DBU for 10 to 20 minutes. The overall yield of bold cyp should be around 75 to 80%

METHANDROSTENOLONE (dbol)

Step 1: The bold cyp from above is stirred in boiling benzene with ethylene glycol and catalytic acid. A Dean-Stark trap should be used to remove water as it is formed. This protects the 3-one as an ethylene ketal.

Step 2: The above protected bold cyp is stirred in boiling methanol/water with NaOH to remove the cyp ester.

Step 3: The 17-OH is oxidized to a ketone with any of a variety of chromium VI reagents.

Step 4: The above 17-one is reacted with methyl magnesium iodide. The reaction is quenched with water and acid. Heating the mixture with the water and acid will remove the ethylene ketal as well, leaving you with methandrostenolone.

METHENOLONE CYPIONATE (Primobolin, although real primo is the enanthate, not the cypionate, I expect little difference in function.

Step 1: 1-Test cyp is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with liquid bromine. The product is 2-bromo-1-methyl-DHT.

Step 2: The bromine is eliminated to give back the 1,2-double bond by stirring with DBU as in the synthesis of bold cyp. The product is methenolone cypionate.

MESTEROLONE (proviron)

1-Test base is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with water to afford mesterolone in a single step.

OXANDROLONE (Anavar)

Step 1: Starting with 1-test base, the 3-one is protected as the ethylene ketal as in the above synthesis of methandrostenolone.

Step 2: The 17-OH is oxidized to a 17-one with chomium VI reagent.

step 3: The 17-methyl is attached with methyl magnesium iodide and the crude reaction mixture is treated with water and acid to quench the reaction and remove the ketal protecting group. The product is 17-methyl-1-test.

Step 4: the 17-methy-1-test is treated with ozone in methanol and then NaOH is added. This allows the purification of the intermediate by recrystallization of the sodium salt. The result is that the double bond is cleaved to give a carboxyolic acid (salt) on one side and an aldehyde on the other. The salt is dissolved in water and acidified to pH=4. NaBH4 is added to reduce the intermediate aldehyde. The resulting alcohol will spontaniously close with the carboxylic acid to give the desired lactone ring. The product is oxandrolone.

OXYMETHYLONE (Anadrol)

17-methyl-1-test from above is reduced with lithium in liquid ammonia. The ammonia is carefully evaporated under a dry N2 atmosphere to give a dry, crystalline enolate. The enolate is dissolved in dry THF and treated with N-formylmorpholine to give oxymethylone as the product.

DROMOSTANOLONE propionate (Masterone)

Step 1: 1-test base is reduced with lithium in liquid ammonia. The ammonia is carefully evaporated under a dry N2 atmosphere to give a dry, crystalline enolate. The enolate is dissolved in dry THF and treated with methyl iodide to install the 2-methyl group.

Step 2: the dromostanolone resulting from step 1 is esterified with propanoyl chloride and pyridine to afford the product, masterone.


Of course, since we all know that 1-test is bunk and isn't a REAL steroid to begin with, non of the derivatives above are REAL steroids either, LOL.
 
Of course, there are easier ways to make some of those. I was trying to make all of them from 1-test.

Boldenone would be easier to make from 1,4-androstadiene-3,17-diol or the 17-cypionate thereof. One can currently purchase the powder legally in the USA but I think it will soon be illegal.

Anyway, just stirring 1,4-androstadiene-3,17-diol with manganese dioxide (MnO2) will oxidize the allylic 3-OH to a 3-ONE and VOILA, boldenone base in one step from a legal prohormone.

4-androstene-3,17-diol can be oxidized to testosterone the same way. If one were to start with the 17-cypionate of 4-androstenediol, test cyp would be the product.

Nandrolone can be made analogously from 19-nor-4-androstene-3,17-diol. MnO2 oxidations are extremely mild and clean reactions. It is unusual for any side reactions to occur at all.
 
Nice tread, spidey

For boldenone, is it also possible to use 2,4,4,6-tetrabromo-2,5-cycohexadien-1-one?

BTW, In the past I used the MnO2 to make nandrolone, but my material (was a bit orange like). You think there are still some side-products made?

Another question, do you know how to make steranabol? That is methenolone but with the methyl group on the 2-position in stead of the 1-position.
 
Sigmund Roid said:
Nice tread, spidey

For boldenone, is it also possible to use 2,4,4,6-tetrabromo-2,5-cycohexadien-1-one?

BTW, In the past I used the MnO2 to make nandrolone, but my material (was a bit orange like). You think there are still some side-products made?

Another question, do you know how to make steranabol? That is methenolone but with the methyl group on the 2-position in stead of the 1-position.

Did you actually use your nandrolone? How did you assess its purity? Better yet, how did you purify it?

Andy
 
Spidey said:


METHANDROSTENOLONE (dbol)

Step 1: The bold cyp from above is stirred in boiling benzene with ethylene glycol and catalytic acid. A Dean-Stark trap should be used to remove water as it is formed. This protects the 3-one as an ethylene ketal.

Step 2: The above protected bold cyp is stirred in boiling methanol/water with NaOH to remove the cyp ester.

Step 3: The 17-OH is oxidized to a ketone with any of a variety of chromium VI reagents.

Step 4: The above 17-one is reacted with methyl magnesium iodide. The reaction is quenched with water and acid. Heating the mixture with the water and acid will remove the ethylene ketal as well, leaving you with methandrostenolone.

METHENOLONE CYPIONATE (Primobolin, although real primo is the enanthate, not the cypionate, I expect little difference in function.

Step 1: 1-Test cyp is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with liquid bromine. The product is 2-bromo-1-methyl-DHT.

Step 2: The bromine is eliminated to give back the 1,2-double bond by stirring with DBU as in the synthesis of bold cyp. The product is methenolone cypionate.

MESTEROLONE (proviron)

1-Test base is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with water to afford mesterolone in a single step.

OXANDROLONE (Anavar)

Step 1: Starting with 1-test base, the 3-one is protected as the ethylene ketal as in the above synthesis of methandrostenolone.

Step 2: The 17-OH is oxidized to a 17-one with chomium VI reagent.

step 3: The 17-methyl is attached with methyl magnesium iodide and the crude reaction mixture is treated with water and acid to quench the reaction and remove the ketal protecting group. The product is 17-methyl-1-test.

B]


No references for these?

With only a light, once over of these procedures.. I question step 2 in your ox synthesis. The 17 alkylation is NOT stereo specific. Alkylation a la Grignard with methyl magmesium iodide would give 17-alpha and beta methyl group.. As far as I know, all AAS are 17 ALPHA alkylated.

If the two products could be separated, I think this one looks reasonably feasible.

Andy
 
Goos stuff spidey.
Can you post the references for those? I'm especially interested in MnO2 oxidation of the diol to give boldenone.
Another conversion you can add to the list is methyl grignard addition to DHEA to yield methandriol (even though people don't like it). One step procedures from over the counter stuff are apealing!
Also, in the case of DHEA (and I suspect testosterone analogues), addition to the carbonyl always occurs from the alpha face due to the adjacent methyl group which is beta.
So you don't have to worry about mixtures of products.
 
Andy13 said:


Did you actually use your nandrolone? How did you assess its purity? Better yet, how did you purify it?

Andy

It was just for giggles and laughs, nothing seriously. I didn't purify it and certainly did not use it. There was probably a mild case of oxidation.
 
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