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HidroCortizone Cream for Gyno?

eddymerckx said:
yea-i kinda wondered what part of the molecule would be carried through by the dmso--cortisol would suck. :worried:
Yeah Bro, its bad enough trying to deal with the itching from the DMSO let alone the cortisol!
 
Donnie Darko said:
By opening up interstitial spaces between cells in the skin to make them more porous. It can become a big matter to make it just through the stratum corneum which consists of dead and living cells both. Making it through the stratum corneum is a pretty big "to do" project for any compound. Most creams just make it into the stratum corneum to soothe, but making it beyond that is where topicals that really penetrate do their job. Admittedly, it can require harsher chemicals and compounds to do just that, but not so bad as pure DMSO or anything that gets absorbed much past the skin barriers to merely get sweated back out.

However, I'm not an expert at this type of compounding, but I will be sooner or later.

I always try to make things as simple as possible. So you are basically saying that they are fat-soluble too so they can be absorbed more deeply?
 
eddymerckx said:
good post
Thanks... I stareted tonigh... god, but it hurt me the cost.. ***** mg pills... I am going for scenario 3... see how it turns... On the cost.. i figure that since I noticed my gyno about two week ago, I have a small lump... so it better than going wiht a 2K surgery.... Hope it works.... Wish me luck brother... I will surely let you all know how it turns out!!!..
 
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Loths said:
Yeah Loths, that thread has been around the traps a while & is the proper proceedure to running letro. It does not always work for gyno that has been present for some time. Letro is still a bitch of a drug to use either on cycle or off & it does have a negative effect on the bodies immune system & ya feel like shit on it. I guess its worth a try for those with estrogen lump issues.
 
nzrodney said:
Yeah Loths, that thread has been around the traps a while & is the proper proceedure to running letro. It does not always work for gyno that has been present for some time. Letro is still a bitch of a drug to use either on cycle or off & it does have a negative effect on the bodies immune system & ya feel like shit on it. I guess its worth a try for those with estrogen lump issues.

Noted Bro, I dig around before buying the Letro... my anabolic 6th ed. 2007 does not mention letro to reverse gyno and nothing on the inume system side effect.... I was unaware of this possibility... I better be carefull... Is like the moonsoon season where I am, definetely dont want a pneunmonia... I notced my gyno two weeks ago..so I am hoping it works for me... I already have the novaldex on the side once I am done with the Letro treatment.

Will search for more info on the net. Will keep all posted!
 
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Brother, I found this ont his link

http://www.bodybuilding-tips.net/s19/t9081.html
++++++++++++++++++++++++++++++++++++++++++++++++++++++

Posted by estray
I personally know people that have taken letro for existing gyno and it worked. Doesnt work for everyone but there are studies to back this. You need to expand your reasearch outside of this site bro. You might learn something.



Letrozole-Femara

Letrozole
Chemical Name: Femara
Drug Class: Type-II Aromatase Inhibitor




Letrozole is Novartis’ entry into the breast cancer treatment world. It’s a Type-II Aromatase Inhibitor (AI), which means that it competitively binds to the aromatase enzyme and inhibits the enzyme’s ability to metabolize testosterone into estrogen. This drug was developed to fight breast cancer by inhibiting the aromatization.

Letrozole is probably the most powerful Aromatase Inhibitor used by athletes today. It has been shown to reduce estrogen levels in women with breast cancer by 98% or more (1). SO clearly, it’s useful for administration to male steroid using athletes who are eager to prevent some of estrogen’s nastier effects on their bodies- development of breast tissue, water retention, etc…

When we take a look at its effects in men, Letrozole actually reduced estrogen in one test subject to undetectable levels (2). In another clinical study, intravenous administration of Letrozole (2.5mcg for 28 days), Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects. In addition, Letrozole also significantly increased LH levels to a whopping 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively. (3) Letrozole was also able to produce a peak LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively.

As you can see, Letrozole is a very powerful drug, and as a result, only very tiny doses are necessary. An effective daily dose of Letrozole for most people is usually about .25-.5mg/day, even though clinically, it is typically used at 2.5mgs/day. Twenty micrograms of Letro was enough, in one study done on men, to reduce estrogen levels by almost a third. (4)

Letrozole’s effects on cholesterol are, really difficult to pin down precisely. They are, in the words of one researcher: "inconsistent.” I can tell you that in my opinion, reducing your bodies estrogen to virtually nothing, will eventually take its toll on your cholesterol profile, and will kill your sex drive and your joints- all of which require estrogen to function safely and effectively.

Even if you take very low doses of Letrozole, it will build up to reasonable blood plasma levels, as it has a 2-4 day half-life, and this long half life also means you need to take Letrozole for 60 days to get a steady blood plasma level (5), and that it will take a very long time to clear out of your system.


Letrozole is the only pharmacological “cure” for gyno that I know of to have ever worked in bodybuilders. In a study conducted on rodents, Letrozole was able to effectively destroy breast tissue tumors (6), and it’s also been effective on many bodybuilders who have used it to eliminate an existing case of gynocomastia. In my case, I used Letro to get rid of my own gyno, by starting with a dose of 2.5mgs/day and then lowering it by .25mcgs per week once my symptoms abated.


With regards to using this stuff on a cycle, unless you are extremely gyno prone, or need to reduce estrogen levels to virtually nothing (for a bodybuilding contest or whatever), it’s going to be too powerful for most people. Male and female competitors typically use it to get the last bits of estrogen related water retention out of them during the final weeks of contest preparation. But when used on a typical cycle, Letro is generally overkill unless a ripped look with zero water and estrogen is desired or if the user is prone to gyno.





References:
1. Clin Cancer Res. 2005 Apr 15;11(8):2809-21.
2. Epilepsy Behav. 2004 Apr;5(2):260-3
3. J Clin Endocrinol Metab. 2005 Oct;90(10):5717-22. Epub 2005 Jul
Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition.
T'Sjoen GG, Giagulli VA, Delva H, Crabbe P, De Bacquer D, Kaufman JM.
4.Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267[Letrozole], in healthy male subjects PF Trunet, P Mueller, AS Bhatnagar, I Dickes, G Monnet and G White
Research and Development Department, CIBA-GEIGY Limited, Basel, Switzerland.
5. Clin Cancer Res. 2003 Jan;9(1 Pt 2):468S-72S.
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
6. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):27-34. Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiolog
 
Loths said:
Brother, I found this ont his link

http://www.bodybuilding-tips.net/s19/t9081.html
++++++++++++++++++++++++++++++++++++++++++++++++++++++

Posted by estray
I personally know people that have taken letro for existing gyno and it worked. Doesnt work for everyone but there are studies to back this. You need to expand your reasearch outside of this site bro. You might learn something.



Letrozole-Femara

Letrozole
Chemical Name: Femara
Drug Class: Type-II Aromatase Inhibitor




Letrozole is Novartis’ entry into the breast cancer treatment world. It’s a Type-II Aromatase Inhibitor (AI), which means that it competitively binds to the aromatase enzyme and inhibits the enzyme’s ability to metabolize testosterone into estrogen. This drug was developed to fight breast cancer by inhibiting the aromatization.

Letrozole is probably the most powerful Aromatase Inhibitor used by athletes today. It has been shown to reduce estrogen levels in women with breast cancer by 98% or more (1). SO clearly, it’s useful for administration to male steroid using athletes who are eager to prevent some of estrogen’s nastier effects on their bodies- development of breast tissue, water retention, etc…

When we take a look at its effects in men, Letrozole actually reduced estrogen in one test subject to undetectable levels (2). In another clinical study, intravenous administration of Letrozole (2.5mcg for 28 days), Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects. In addition, Letrozole also significantly increased LH levels to a whopping 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively. (3) Letrozole was also able to produce a peak LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively.

As you can see, Letrozole is a very powerful drug, and as a result, only very tiny doses are necessary. An effective daily dose of Letrozole for most people is usually about .25-.5mg/day, even though clinically, it is typically used at 2.5mgs/day. Twenty micrograms of Letro was enough, in one study done on men, to reduce estrogen levels by almost a third. (4)

Letrozole’s effects on cholesterol are, really difficult to pin down precisely. They are, in the words of one researcher: "inconsistent.” I can tell you that in my opinion, reducing your bodies estrogen to virtually nothing, will eventually take its toll on your cholesterol profile, and will kill your sex drive and your joints- all of which require estrogen to function safely and effectively.

Even if you take very low doses of Letrozole, it will build up to reasonable blood plasma levels, as it has a 2-4 day half-life, and this long half life also means you need to take Letrozole for 60 days to get a steady blood plasma level (5), and that it will take a very long time to clear out of your system.


Letrozole is the only pharmacological “cure” for gyno that I know of to have ever worked in bodybuilders. In a study conducted on rodents, Letrozole was able to effectively destroy breast tissue tumors (6), and it’s also been effective on many bodybuilders who have used it to eliminate an existing case of gynocomastia. In my case, I used Letro to get rid of my own gyno, by starting with a dose of 2.5mgs/day and then lowering it by .25mcgs per week once my symptoms abated.


With regards to using this stuff on a cycle, unless you are extremely gyno prone, or need to reduce estrogen levels to virtually nothing (for a bodybuilding contest or whatever), it’s going to be too powerful for most people. Male and female competitors typically use it to get the last bits of estrogen related water retention out of them during the final weeks of contest preparation. But when used on a typical cycle, Letro is generally overkill unless a ripped look with zero water and estrogen is desired or if the user is prone to gyno.





References:
1. Clin Cancer Res. 2005 Apr 15;11(8):2809-21.
2. Epilepsy Behav. 2004 Apr;5(2):260-3
3. J Clin Endocrinol Metab. 2005 Oct;90(10):5717-22. Epub 2005 Jul
Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition.
T'Sjoen GG, Giagulli VA, Delva H, Crabbe P, De Bacquer D, Kaufman JM.
4.Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267[Letrozole], in healthy male subjects PF Trunet, P Mueller, AS Bhatnagar, I Dickes, G Monnet and G White
Research and Development Department, CIBA-GEIGY Limited, Basel, Switzerland.
5. Clin Cancer Res. 2003 Jan;9(1 Pt 2):468S-72S.
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
6. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):27-34. Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiolog
Bro I have been in the game for few years & there is not much that I have not tried myself. Letro does have its uses, there is no doubt about that but it is a very powerful drug & needs to be used sparingly by the average Joe BBer. The method of administration you initially posted is correct admin of femera & then PCT using nolva or another lesser AI like adex or Asan is correct & kills many lump issues with users. Just be aware that the drug is invasive & has side issues.
 
nzrodney said:
Bro I have been in the game for few years & there is not much that I have not tried myself. Letro does have its uses, there is no doubt about that but it is a very powerful drug & needs to be used sparingly by the average Joe BBer. The method of administration you initially posted is correct admin of femera & then PCT using nolva or another lesser AI like adex or Asan is correct & kills many lump issues with users. Just be aware that the drug is invasive & has side issues.

nzrodney, thanks... I have one question... How long should I give Letro to tell if is working... I know we all have different Bio-chemistries, but there is an average?

One final note on the hydro Cortizone, it ease the pain, but did not stop the gyno.... i tried if for a week before letro...From the posts in this thread, I dont thinking is worth messing around with.

Thanks to all for contributing to this thread!
 
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