Please Scroll Down to See Forums Below
HidroCortizone Cream for Gyno?
- Thread starter Loths
- Start date
Donnie Darko
Lurking Around
I don't see hydrocortisone cream helping unless they itch.
Donnie Darko said:
My logic is that is if the Cortizone on the cream can compete with the estrogen on the male breat tissue, the estrogen will not be able to attach to the receptors, therefore no gyno...
Now, your post good me thinking... if hydrocortizone only take the pain away? Like a pain killer.... or does it do more....????
Donnie Darko
Lurking Around
I don't even know if hydrocortisone cream can penetrate beyond superficial layers of the skin.
dmso?
Donnie Darko
Lurking Around
Perhaps, but when I think of hydrocortisone I think of it metabolizing to cortisol only to make the breast tissue a bit fatter too....assuming the hydrocortisone is delivered that deep.eddymerckx said:
Donnie Darko said:
yea-i kinda wondered what part of the molecule would be carried through by the dmso--cortisol would suck.
Donnie Darko
Lurking Around
It isn't so much as a part of the molecule, but how the entire thing will be metabolized. However, I don't think any hydrocortisone creams could be brought through the skin that far anyway.eddymerckx said:yea-i kinda wondered what part of the molecule would be carried through by the dmso--cortisol would suck.
Donnie Darko said:
i thought the dmso would only attach to something free--if you had pure hydrocort w/o all the binders would it metabol that quick?
Donnie Darko
Lurking Around
In all honesty, I am not sure how hydrocortisone would metabolize systemically. To be totally honest, I don't even know if anyone has ever done a study topical hydrocortisone or any hydrocortisone metabolizing within the body. I did some searches today, but I couldn't find much of anything worthwhile.
Donnie Darko said:
how does the topical fat burners get through the skin?
Donnie Darko
Lurking Around
By opening up interstitial spaces between cells in the skin to make them more porous. It can become a big matter to make it just through the stratum corneum which consists of dead and living cells both. Making it through the stratum corneum is a pretty big "to do" project for any compound. Most creams just make it into the stratum corneum to soothe, but making it beyond that is where topicals that really penetrate do their job. Admittedly, it can require harsher chemicals and compounds to do just that, but not so bad as pure DMSO or anything that gets absorbed much past the skin barriers to merely get sweated back out.
However, I'm not an expert at this type of compounding, but I will be sooner or later.
However, I'm not an expert at this type of compounding, but I will be sooner or later.
i think i will need to try TargeX Heat and TargeX BurnDonnie Darko said:
702daswoll1
New member
What about hemmorhoid cream? It shrinks swelling a lot actually. Maybe little preperation H the day before hitting up the beach might work wonders... Food for thought. Man Im glad i dont have any man-boobs..
702daswoll1 said:
me too--adex and aromasin are my friends.
Mavafanculo
New member
Donnie Darko said:
I ran across writeups before on various topical cortizone products (the stronger stuff) which indicated "some" systemic absorption is possible.
I'm pretty sensitive to the positive and negative effects of drugs, and i can tell you there IS systemic absortion with all the resulting sides altho slight compared to something like a cortizone shot
-
on the OP hypothesis, while testosterone competes with cortisol for binding the cortisol receptor, I've never run across anything indicating that cortisol would compete with estrogen for binding the Estrogen-receptor .
but given the 1st part above ^^ the cure would be at least as bad as the disease so to speak. there's estab;ished better ways to prevent and treat gyno, why try to go down this route???
ceo said:
Great comments.. I just had the idea because... guess what.. I am getting some gyno.. the swellng, a little pain, and the accumulation of mas under the nipple... SUcks.. its small, not noticeable yet... but I know is there and I am considering options....
I have access to Novaldex and Clomid... Arimidex is WAY to expensive for me....
WHy I have not takeng any of this? Well to be quite honest, I dont like how it make the TEST weaker... couple of weeks ago I took 200mg of test, and 20mg of novaldex... I was less pump,and lost strength... I did this for 3 days.. ten reduce Novaldex to 10mg, for the rest of the week.... What I am thinking of doing it to take 5mg/day to see who it works...
What other options beside surgery we have to reduce gyno? I read a post that injecting hGC on the site will burn some of it away....is that is true, how much HGC has to be injected?
nzrodney
Banned
Well you have to weigh up your options Bro. Run your cycle through without any SERMs or AI's & put up with the gyno & maybe get the max gains in mass. Or, deal to the gyno on cycle with at least 20mg ed Nolva or use an AI like Letrozole to try & reduce the existing gyno, & be happy with reduced gains & strength in the gym. There are lots of threads dealing to this issue to research.Loths said:
nzrodney said:
Brothers check this link out;
http://forums.steroid.com/showthread.php?t=236880&highlight=gyno+reversal
Loths said:
good post
Thanks... I stareted tonigh... god, but it hurt me the cost.. ***** mg pills... I am going for scenario 3... see how it turns... On the cost.. i figure that since I noticed my gyno about two week ago, I have a small lump... so it better than going wiht a 2K surgery.... Hope it works.... Wish me luck brother... I will surely let you all know how it turns out!!!..eddymerckx said:
Last edited by a moderator:
nzrodney
Banned
Yeah Loths, that thread has been around the traps a while & is the proper proceedure to running letro. It does not always work for gyno that has been present for some time. Letro is still a bitch of a drug to use either on cycle or off & it does have a negative effect on the bodies immune system & ya feel like shit on it. I guess its worth a try for those with estrogen lump issues.Loths said:
nzrodney said:
Noted Bro, I dig around before buying the Letro... my anabolic 6th ed. 2007 does not mention letro to reverse gyno and nothing on the inume system side effect.... I was unaware of this possibility... I better be carefull... Is like the moonsoon season where I am, definetely dont want a pneunmonia... I notced my gyno two weeks ago..so I am hoping it works for me... I already have the novaldex on the side once I am done with the Letro treatment.
Will search for more info on the net. Will keep all posted!
Last edited:
Brother, I found this ont his link
http://www.bodybuilding-tips.net/s19/t9081.html
++++++++++++++++++++++++++++++++++++++++++++++++++++++
Posted by estray
I personally know people that have taken letro for existing gyno and it worked. Doesnt work for everyone but there are studies to back this. You need to expand your reasearch outside of this site bro. You might learn something.
Letrozole-Femara
Letrozole
Chemical Name: Femara
Drug Class: Type-II Aromatase Inhibitor
Letrozole is Novartis’ entry into the breast cancer treatment world. It’s a Type-II Aromatase Inhibitor (AI), which means that it competitively binds to the aromatase enzyme and inhibits the enzyme’s ability to metabolize testosterone into estrogen. This drug was developed to fight breast cancer by inhibiting the aromatization.
Letrozole is probably the most powerful Aromatase Inhibitor used by athletes today. It has been shown to reduce estrogen levels in women with breast cancer by 98% or more (1). SO clearly, it’s useful for administration to male steroid using athletes who are eager to prevent some of estrogen’s nastier effects on their bodies- development of breast tissue, water retention, etc…
When we take a look at its effects in men, Letrozole actually reduced estrogen in one test subject to undetectable levels (2). In another clinical study, intravenous administration of Letrozole (2.5mcg for 28 days), Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects. In addition, Letrozole also significantly increased LH levels to a whopping 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively. (3) Letrozole was also able to produce a peak LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively.
As you can see, Letrozole is a very powerful drug, and as a result, only very tiny doses are necessary. An effective daily dose of Letrozole for most people is usually about .25-.5mg/day, even though clinically, it is typically used at 2.5mgs/day. Twenty micrograms of Letro was enough, in one study done on men, to reduce estrogen levels by almost a third. (4)
Letrozole’s effects on cholesterol are, really difficult to pin down precisely. They are, in the words of one researcher: "inconsistent.” I can tell you that in my opinion, reducing your bodies estrogen to virtually nothing, will eventually take its toll on your cholesterol profile, and will kill your sex drive and your joints- all of which require estrogen to function safely and effectively.
Even if you take very low doses of Letrozole, it will build up to reasonable blood plasma levels, as it has a 2-4 day half-life, and this long half life also means you need to take Letrozole for 60 days to get a steady blood plasma level (5), and that it will take a very long time to clear out of your system.
Letrozole is the only pharmacological “cure” for gyno that I know of to have ever worked in bodybuilders. In a study conducted on rodents, Letrozole was able to effectively destroy breast tissue tumors (6), and it’s also been effective on many bodybuilders who have used it to eliminate an existing case of gynocomastia. In my case, I used Letro to get rid of my own gyno, by starting with a dose of 2.5mgs/day and then lowering it by .25mcgs per week once my symptoms abated.
With regards to using this stuff on a cycle, unless you are extremely gyno prone, or need to reduce estrogen levels to virtually nothing (for a bodybuilding contest or whatever), it’s going to be too powerful for most people. Male and female competitors typically use it to get the last bits of estrogen related water retention out of them during the final weeks of contest preparation. But when used on a typical cycle, Letro is generally overkill unless a ripped look with zero water and estrogen is desired or if the user is prone to gyno.
References:
1. Clin Cancer Res. 2005 Apr 15;11(8):2809-21.
2. Epilepsy Behav. 2004 Apr;5(2):260-3
3. J Clin Endocrinol Metab. 2005 Oct;90(10):5717-22. Epub 2005 Jul
Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition.
T'Sjoen GG, Giagulli VA, Delva H, Crabbe P, De Bacquer D, Kaufman JM.
4.Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267[Letrozole], in healthy male subjects PF Trunet, P Mueller, AS Bhatnagar, I Dickes, G Monnet and G White
Research and Development Department, CIBA-GEIGY Limited, Basel, Switzerland.
5. Clin Cancer Res. 2003 Jan;9(1 Pt 2):468S-72S.
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
6. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):27-34. Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiolog
http://www.bodybuilding-tips.net/s19/t9081.html
++++++++++++++++++++++++++++++++++++++++++++++++++++++
Posted by estray
I personally know people that have taken letro for existing gyno and it worked. Doesnt work for everyone but there are studies to back this. You need to expand your reasearch outside of this site bro. You might learn something.
Letrozole-Femara
Letrozole
Chemical Name: Femara
Drug Class: Type-II Aromatase Inhibitor
Letrozole is Novartis’ entry into the breast cancer treatment world. It’s a Type-II Aromatase Inhibitor (AI), which means that it competitively binds to the aromatase enzyme and inhibits the enzyme’s ability to metabolize testosterone into estrogen. This drug was developed to fight breast cancer by inhibiting the aromatization.
Letrozole is probably the most powerful Aromatase Inhibitor used by athletes today. It has been shown to reduce estrogen levels in women with breast cancer by 98% or more (1). SO clearly, it’s useful for administration to male steroid using athletes who are eager to prevent some of estrogen’s nastier effects on their bodies- development of breast tissue, water retention, etc…
When we take a look at its effects in men, Letrozole actually reduced estrogen in one test subject to undetectable levels (2). In another clinical study, intravenous administration of Letrozole (2.5mcg for 28 days), Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects. In addition, Letrozole also significantly increased LH levels to a whopping 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively. (3) Letrozole was also able to produce a peak LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively.
As you can see, Letrozole is a very powerful drug, and as a result, only very tiny doses are necessary. An effective daily dose of Letrozole for most people is usually about .25-.5mg/day, even though clinically, it is typically used at 2.5mgs/day. Twenty micrograms of Letro was enough, in one study done on men, to reduce estrogen levels by almost a third. (4)
Letrozole’s effects on cholesterol are, really difficult to pin down precisely. They are, in the words of one researcher: "inconsistent.” I can tell you that in my opinion, reducing your bodies estrogen to virtually nothing, will eventually take its toll on your cholesterol profile, and will kill your sex drive and your joints- all of which require estrogen to function safely and effectively.
Even if you take very low doses of Letrozole, it will build up to reasonable blood plasma levels, as it has a 2-4 day half-life, and this long half life also means you need to take Letrozole for 60 days to get a steady blood plasma level (5), and that it will take a very long time to clear out of your system.
Letrozole is the only pharmacological “cure” for gyno that I know of to have ever worked in bodybuilders. In a study conducted on rodents, Letrozole was able to effectively destroy breast tissue tumors (6), and it’s also been effective on many bodybuilders who have used it to eliminate an existing case of gynocomastia. In my case, I used Letro to get rid of my own gyno, by starting with a dose of 2.5mgs/day and then lowering it by .25mcgs per week once my symptoms abated.
With regards to using this stuff on a cycle, unless you are extremely gyno prone, or need to reduce estrogen levels to virtually nothing (for a bodybuilding contest or whatever), it’s going to be too powerful for most people. Male and female competitors typically use it to get the last bits of estrogen related water retention out of them during the final weeks of contest preparation. But when used on a typical cycle, Letro is generally overkill unless a ripped look with zero water and estrogen is desired or if the user is prone to gyno.
References:
1. Clin Cancer Res. 2005 Apr 15;11(8):2809-21.
2. Epilepsy Behav. 2004 Apr;5(2):260-3
3. J Clin Endocrinol Metab. 2005 Oct;90(10):5717-22. Epub 2005 Jul
Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition.
T'Sjoen GG, Giagulli VA, Delva H, Crabbe P, De Bacquer D, Kaufman JM.
4.Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267[Letrozole], in healthy male subjects PF Trunet, P Mueller, AS Bhatnagar, I Dickes, G Monnet and G White
Research and Development Department, CIBA-GEIGY Limited, Basel, Switzerland.
5. Clin Cancer Res. 2003 Jan;9(1 Pt 2):468S-72S.
Department of Endocrinology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
6. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):27-34. Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiolog
nzrodney
Banned
Bro I have been in the game for few years & there is not much that I have not tried myself. Letro does have its uses, there is no doubt about that but it is a very powerful drug & needs to be used sparingly by the average Joe BBer. The method of administration you initially posted is correct admin of femera & then PCT using nolva or another lesser AI like adex or Asan is correct & kills many lump issues with users. Just be aware that the drug is invasive & has side issues.Loths said:
nzrodney said:
nzrodney, thanks... I have one question... How long should I give Letro to tell if is working... I know we all have different Bio-chemistries, but there is an average?
One final note on the hydro Cortizone, it ease the pain, but did not stop the gyno.... i tried if for a week before letro...From the posts in this thread, I dont thinking is worth messing around with.
Thanks to all for contributing to this thread!
nzrodney said:
Thanks.. I opened another thread titled: GYNO and Letro.. Since the HydroCortizone was explored...
On Letro, so far it appear to be working, but I wonder about removing the lump... I mean, how can it break that down.... Any hose.. here is the link:
http://www.elitefitness.com/forum/s...rum/gynecomastia-femera-letrozole-597603.html
Last edited:
sirbishop6
New member
strong bump. do you guys know anything about Iontophoresis and its ability to help drugs penetrate the skin more effectively? Check out the wikipedia article. I can't post links yet. I was thinking of running some topical clen with this method, as well as some hydrocortisone cream on my shoulder (hesistant about an injection at this point).
Similar threads
