HGH Injections

[DrJMW]

Great info!

However, you will get a lot of scar tissue in the muscle when you poke 2 times per day for a lot of weeks. Especially if you cannot get any needle that is smaller than 25 gauge.

Do you also advocate IM slin shots?

You won't get scar tissue if you move the injection sites around the body, constantly rotating.

 

[Latamier]

Latamier,
did you shoot 2 & 2 or all at once? did you use slin?

I did 2 and 2. NO I did not use slin. The shit is too dangerous, and I am obviously not a pro so I dont really need that little extra slin SUPPOSEDLY adds to a cycle. Oh, and I value my life entirely too much to screw with a drug like that.

 

[greg21]

This is the feedback I am getting from many experienced users. why not go with what works? What are the negative to IM injections of HGH--anyone?

Well bro, I do remember Ironman posting a while back about the possibility of destroying muscle tissue when injected IM. Im not saying this is true...but is what scared me from doing it.

 

[graffixx]

great! i hope not! i just started today. 1.5 iu IM in the delt. no probs yet. i put the humulinR that mt friend gave me on the shelf for now. i will work up to 4iu a day IM (2 & 2) and let you know how it goes. i'll just run it with omna or enth for now and see what happens. the slin is there if i get the urge.

 

[greg21]

I just spoke with King Kamali about this issue. He claims that sub-q is preferred. I would like to hear more about IM though. Graffix, keep us posted bro.

 

[graffixx]

i will but, if you stop hearing from me all of the sudden, DON'T shoot IM!!! lol

 

[liftsiron]

DrJMW do you have any empirical data to back up this thread? Its not that I doubt your word but I do remember you advising someone to add 9cc's of sterile water to a single 18iu vail. I would supect that injecting 1cc of water sq would cause the problems that you speak of. I would like to locate studies that show IM is superior to SQ. Thank you.

 

[graffixx]

3rd shot due today, not dead yet, no sides...but i thought i was so supossed to be 50lbs bigger bt now! NOT.

i will skip sun and then go to 2 shots of 1.5 per day monday.

more info is GOOD, keep it coming...

 

[Mr.Dank]

Subcutaneous (SC) vs. Intramuscular (IM)

Even though many people, including the HGH manufacturers, recommend SC injections of HGH, I do not agree. I prefer IM injections. This is based on pharmacology and clinical observation.

The advantages of injecting IM is one--less discomfort and adverse effects, and two--a greater increase in IGF levels than injecting into SC tissue (adipose). You still get the same fat burning effects that you would injecting SC, but you also get greater IGF levels doing so. SC Injection does not allow the HGH to get into the bloodstream to raise IGF levels. The HGH stays localized in the adipose tissue, only providing fat-burning.

I have spent 100's of hours doing research on medline with respect to hgh. There are different tradeoffs with respect to injecting hgh IV, IM, or SC. Here are some facts,

Injecting IV yields 100% absorption into the blood stream.
Injecting SC yields 75% absorption. (Humatrope)
Injecting IM yields 63% absorption. (humatrope)

So if you inject 10iu IM you only absorb 6.3IU, if you inject 10iu SC you only absorb 7.5IU................

If you look at the prescribing info for humitrope they include a graph. If you do the math you will find that for a 100kg person, 2iu SC will increase plasma concentrations by 2-4 ng/ml over a period of 8hr. 4ng/ml corresponding to the peak concentration, and 2ng/ml corresponding to the beginning and end of the 8hr period.
This amount of gh is around a normal persons baseline levels. You basically produce gh in spurts and in-between those spurts you have the baseline levels.
It has been determined in numerous studies the growth and especially IGF-1 production is greatly increased by continuos infusion of hgh, when compared to the same amount given in pulses. I have medline abstracts on these at work.
Basically the studies say that if you took 10IU of hgh IV spread out to 10-20 inj a day (to simulate your bodies pulses of gh production), and compared those results with 10IU being given IV but continuously over a 24hr period (maintaining the same blood concentration) your body would produce more IGF and linear growth from the continuous infusion. These studies suggest that IGF-1 production with response to gh is more a function of its baseline levels.

This is why you would get more IGF-1 by injecting IM. However, you will absorb less than you would if taken SC. The absorption ratio of IM over SC based on humitrope is 0.84. So if you inject IM you will only absorb 84 percent of the amount of gh as compared to SC.

The other thing is if you inj IM or SC feedback is going to occur through IGF-1 which has a long half-life. So taking it in the morning verses at night seems senseless.

http://pi.lilly.com/us/humatrope-pi.pdf

 

[graffixx]

so u r saying that the time of day for IM doesn't matter, the same feedback will occur. and that whatever your daily total is should be spread out to as many shots as possible. and only count .63 of whatever amount you are taking IM.

do you have data on the min dose for growth vs repair of connective tissue? or will it be the same amount?