swale, who is a very well known hrt doctor, prescribes it at 250-500iu 2x weekly all the way through the cycle, that way testicular atrophy does not happen in the first place. That is the most effective way to take it, especially if you run long cycles. basically your two options are, let your nuts die, then after months of them being DOA, try to bring them back from the dead....or two, keep them alive throughout your cycle