macrophage69alpha
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CO B-man said:wtf?
a small percentage is converted to methamphetamine and amphetamine.
J Occup Environ Med. 2002 May;44(5):435-50. Links
Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results.Cody JT.
Academy of Health Sciences, MCCS-HMP PA Branch, 3151 Scott Road, Ft Sam, Houston, TX 78234-6138, USA. [email protected]
Medical Review Officer interpretation of laboratory results is an important component of drug testing programs. The clinical evaluation of laboratory results to assess the possibility of appropriate medical use of a drug is a task with many different facets, depending on the drug class considered. This intercession prevents the reporting of positive results unless it is apparent that drugs were used illicitly. In addition to the commonly encountered prescribed drugs that yield positive drug testing results, other sources of positive results must be considered. This review describes a series of compounds referred to as "precursor" drugs that are metabolized by the body to amphetamine and/or methamphetamine. These compounds lead to positive results for amphetamines even though neither amphetamine nor methamphetamine were used, a possibility that must be considered in the review of laboratory results. Description of the drugs, their clinical indications, and results seen following administration are provided. This information allows for the informed evaluation of results with regard to the potential involvement of these drugs.
Neurobiology (Bp). 1999;7(2):247-54. Links
Metabolic transformation of deprenyl enantiomers in rats.Szoko E, Kalasz H, Magyar K.
Department of Pharmacodynamics, Semmelweis University of Medicine, Budapest, Hungary.
The optical isomers of deprenyl have different pharmacological activities and potency. Selegiline, an (-)-isomer, is the more potent monoamine oxidase B enzyme inhibitor, and this substance is used in the therapy of Parkinson's disease. The neuroprotective and neuronal rescue effects of deprenyl, as well as the psychostimulant action of its metabolites, methamphetamine and amphetamine are also different for the enantiomers. In this study the biotransformation of deprenyl enantiomers was compared. Stereoselective dealkylation of both optical isomers was found as major metabolic alteration. The difference in the ratio of the formed metabolites suggests the existence of preferred metabolic pathways for the enantiomers.
the primary metabolite is desmethylselegiline, only small trace amounts are converted to methamphetamine and amphetamine.