Follow along with the video below to see how to install our site as a web app on your home screen.
Note: This feature may not be available in some browsers.
thankgodformexico said:Buffdoc,
I really am failing to see how there is proof lacking that dutasteride is a superior 5ar inhibitor. It has been released to treat BPH for this sole fact. If it wasn't going to outperform finasteride glaxo would not stand to gain by persuing it. It outperforms finasteride singnificantly at 3 AND 6 months, inhibiting dht at 90%.
It blocks not only BOTH enzymes, but it even dose better at blocking the type 2 than finasteride does (partly because of it's longer half life, like you have brought up.) Dht levels remain about the same around the clock on dutasteride, whereas they spike after 12hours with finasteride (leading some people to opt to take it twice daily). This is probably one of the reasons that it outperforms finasteride REGROWING HAIR, dual 5ar inhibition aside.
We still do not know if the phase 3 trials for hairloss will happen but it was put on hold for whatever reason. No one knows for sure why they did it, so to say it was because of side effects is speculative.
I don't understand why you wouldn't want to get rid of as much dht as possible when it comes to hairloss, even at the expense of a possible slight increase in sexual side effects, which can be countered other ways. Especially when in the case of many people on this board you are going to be puting synthetic testosterone into your body in mass quantity. The less coversion via 5ar the better, wouldn't you think?
I would also point out that the type 1 5ar is highly involved with sebum production in the skin/scalp, so it has potential to reduce acne as well as leave a less oily environment on the scalp preventing exsessive sebum build up which can help decrease the inflamitory process of mpb.
This is science here man, backed by studies, I'm not making any great leaps or being overly inthusiastic. Dutasteride simply IS a better 5ar antagonist, DOES regrow more hair than both finasteride and minoxidil. This is not opinion.
BTW, I'm sure you know that a handful of educated people were using finasteride by taking proscar years before it was ever in the pipeline to be marketed for hairloss as propecia. Just because a drug has only been approved by the fda to treat one ailment, does not mean that it doesn't effectively treat another ailment who's underlying mechanisms are related. Dr.'s prescribe drugs for off label use all the time, for a variety of reasons with effective results.
Please don't prevent anyone here from persuing better treatments that are scientifically backed in research to treat their hairloss. MPB is a horrid, horrid curse some of us are bestowed with and I like to see everyone get the best information possible.
thankgodformexico said:Buffdoc,
This will be my last attempt to get through to you. You just keep replying with generalized statements, nothing factual, nothing scientific of your own. I am the one who has provided the trial results, and I am willing to post the rest of the studies as well. Until you can provide me with something specific, for example how I am misreading a study, which study it is, show me a study of your own with different results, or even explain to me what your point is SPECIFICLY (what I am not being critical enough about) then this is useless. PLease enlighten me.
Actually, it doesn't block DHT effects. It's probably a weak 5-AR inhibitor, therefore decreases DHT formation. Not proven to work on hair loss by any good studies I'm aware of, but probably works to some degree for both BPH and androgenetic alopecia. Think of it as weak finasteride. Anybody have other evidence on this one?