Sometimes puffy and red, sometimes sore, sometimes constantly aroused, sometimes achy. There are as many symptoms as there are nipples bro. My rule of thumb, though a bit cautious, is that any time you think to yourself, "Was that a symptom?" You should count it as a symptom and start antiestros. Better yet, run anti-estros regardless and adjust dosages according to need. Gyno sucks and surgery sucks more. The antiestros are not that expensive, while the surgery IS, and they aren't hard to get, while a good surgeon IS. Out.