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Glutamine: Why It's Important

beefybull

Banned
I originally posted this on the Anabolic board, but figured it'd be good to post here also.

What is Glutamine?
Glutamine is considered a "conditionally essential amino acid". It makes up roughly 61% of the amino acid pool in skeletal muscle.

What does Glutamine do?
- It is an acid/base balancer
- It is a nitrogen carrier
- It is a precursor to macromolecules (proteins & nucleic acids)
- Glutamine (not carbs or fat) is the preferred source of fuel for rapidly dividing cells, such as enterocytes (intestinal cells) and lymphocytes (immune system cells).
- It is a cell volumizer
- It aids in recovery
- It performs other functions as well

How much should I take & when?
Although glutamine is a popular supplement, this question pops up quite often. The amount of glutamine you should take depends on your bodyweight. Dosages at .57g/kg bodyweight have been shown to be safe in short term use. The body needs a minimum of .2g/kg to have a positive effect on nitrogen balance. Here is a chart of daily dosages by body weight (at .2g/kg):
140lbs - 12.7g
150lbs - 13.6g
160lbs - 14.5g
170lbs - 15.4g
180lbs - 16.3g
190lbs - 17.2g
200lbs - 18.1g
210lbs - 19.1g
220lbs - 20g
230lbs - 20.9g
240lbs - 21.9g
250lbs - 22.7g
260lbs - 23.6g
270lbs - 24.5g

Although you could probably take your full daily dosage at once, it may not be the most comfortable thing to do so. Glutamine should not be taken with food, as it will drastically decrease the amount of glutamine that is absorbed. It is best taken post-workout with carbs & protein, or before bed, since Glutamine is believed to cause an increase in growth hormone (and this is an ideal time for this). As Huckleberry Finnaplex suggested, you could also take it in the morning on an empty stomach.

Glutamine is easily one of the top 5 OTC supplements that a bodybuilder should use. In fact, it could be #1 or maybe a close #2 (behind Creatine). It is currently more expensive than creatine, but the price has drastically dropped over the past 18 months. Hope this helps!

BeefyBull
 
Glutamine promises a lot of benefits, it is the uptake that seems to be of the greatest concern... There seems to be a lot of conflicting evidence on bio-availability as well as "best time" to take..
 
Glutamine is questionable at this time. Dosages taken in studies are high and costly. I've never been impressed, I just take my protein like a good boy and don't worry about additional glutamine anymore.
 
asdf

glutamine for me has helped huge. In high dosages though. at 195lbs with abs under good lighting I was taking about 40 g´s a day, and making amazing gains.
try
10gs in the morning
10gs pre workout
10gs postworkout
10gs before bed

or whatever dosage fits your body weight, but those times seem to be the most effective
 
i thought i would add my 2 cents worth (hope it does some good) - i am a 55 year old male that just 5 years ago had a 44 inch wist and weighed 262 - now mind you, i've been a gym rat as such most all of my life but after age 45 everyting changed - working out more did not produce weight loss - just a bigger appetite and increasing the food intake just put on more body fat (not lean muscle) and then my immune system would become depressed as i over trained more and more - happened to come across a book about the value of amino acids and began using them taking in l-glutamine, l-lysine, l-arginine, and l-orithine mostly at night before bedtime - what this did was to slowly bring my body out of the catabolic state and allow for the growth of lean muscle mass (but did not lose as much body fat as i wanted) - as time went on i modified my workout schedule to actually do less and got better results - with the introduction of pro-hormones i was able to now take off body fat and increase my muscle mass (unfortunately the fda banned them, of course) but have been able to maintain the gains (am now working on getting down to a 34 inch waist and increase my strength levels) by using selected herbs that allow the release of free test (oat straw) - i realize that all of this is probably pretty mundane to you hardcore guys but there are a lot of guys like me who (because the market went south and other econmic factors) are looking at working to age 80 or so and refuse to give in completely to aging and there are very few forums they can turn to - doctors don't having a clue and the drug companies are coming up with crap everyday to push on the public and to be frank this kind of forum is the only way someone like myself can get info on the only thing that can deal with aging - creating growth (muscle growth for example in the body) - all of you young guys will have to deal with these same issues in the future and it is my hope that you will be able to benefit in the future as guys like me learn new things and pass them on - now about steroids, that is another issue....
 
macrophage69alpha said:
Glutamine promises a lot of benefits, it is the uptake that seems to be of the greatest concern... There seems to be a lot of conflicting evidence on bio-availability as well as "best time" to take..

The jury is still out on glutamine. Like Macro said, it's the uptake that is of concern. At this point in time, it's considered "expensive GI food" by most people in the know.

Former studies were based upon intravenous dosages; glutamine's effectiveness via the alimentary tract has not yet been fully established.

That being said, there is anecdotal evidence, just no controlled studies.

There may be promise in glutamine peptides, but that has not yet been established, either.
 
There must have been some absorption for them to get the result.

Study used: .1g/kg 4x/day

For a 220lb bodybuilder (100kg), that'd be 10g, 4x/day, just like polishhammer did it.


In the study below:

"We conclude that chronic glutamine supplementation during interval training results in higher nasal IgA than placebo but does not affect salivary IgA concentration or output."

Chronic glutamine supplementation increases nasal but not salivary IgA during 9 days of interval training. ->
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15107413
 
"We found that glutamine concentration in resting subjects decreased from T1 to T4 (P < 0.05) and was not altered by supplementation."

C'mon, Omega...get that second generation peptide-bonded glutamine out thereso it can be studied! I WANT it to work! :)
 
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