you can take 100mg if u want. it would be better because the half life of oral winny is only like 8 or 9 hours (dont quote me on that) when i was on his winny i took one in the morn and one at night. better off just taking the 2, and not splitting 50 into 2 25mg halves. with his pills, the 50mg isnt evely spread out. u may get one with 45mg and one with 5