Here's why I say don't waste a dime on GH, particularly Serostim:
"Effect of growth hormone and resistance exercise on muscle growth in young men", Yarasheski KE; Campbell JA; Smith K; Rennie MJ; Holloszy JO; Bier DM. Am J Physiol, 262(3 Pt 1):E261-7 1992 Mar
Serostim (a growth hormone) given at 2 to 4 times normal physiological levels (9 IU per day) did not produce significant muscle growth in young men who lifted weights. While there was an increase in LBM, the LBM that was gained was basically not muscle, but water or other tissue.
"Effect of growth hormone and resistance exercise on muscle growth and strength in older men", Yarasheski KE; Zachwieja JJ; Campbell JA; Bier DM. Am J Physiol, 268(2 Pt 1):E268-76 1995 Feb
In this study there was also a lack of effect on muscle tissue, but in older men who lifted weights. The authors said: "The greater increase in fat free mass (FFM) with GH treatment seemed to be due to an increase in noncontractile protein and fluid retention."
"Growth hormone effects on metabolism, body composition, muscle mass, and strength". Yarasheski KE. Exerc Sport Sci Rev, 22():285-312 1994
In this one the author said, "On the basis of the similar increases in muscle protein synthesis, muscle cross-sectional area, and muscle strength observed in placebo and GH-treated exercising young adults, it is doubtful that the nitrogen retention associated with daily GH treatment results in any increase in contractile protein, improved muscle function, strength or athletic performance."
At the Cannes Conference data from a study by Donald P. Kotler, MD reported:
"The results of an interim analysis of a 6-month open-label trial of the safety and efficacy of Serostim growth hormone upon visceral adipose tissue, as determined by whole body MRI scanning. Therapy with 6mg of Serostim rhGH did not promote a significant change in skeletal muscle during the first 12 weeks of therapy in the 8 subjects for whom repeat MRI data were available. Cost for 12 weeks was approximately $19,000.
The political problem here is that Serostim GH has been promoted as an anabolic agent with claims by Serono sales people that GH builds muscle. Note that testosterone and anabolic steroids have been proven to be anabolic to muscle tissue, and testosterone has been shown to significantly increase muscle growth, but because of the deception of Serono's sales people many HIV(+) people who have needed anabolic steroids to build their bodies and their health have been given Serostim GH by well-intentioned, but misinformed physicians..."
Growth hormone may have some benefit to elderly men wishing to have slightly elevated fat burning, but if you are using GH to gain muscle, you are wasting your money.
-Stew