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GH and T4
- Thread starter informed09
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Cauliflower Ear
New member
bump for more experience
A
Anthony Roberts
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MR. BMJ said:
Because he's answering it over here instead. I invited him here as a personal friend and asked him to chime in.
In a practical sense, there is a better return on his investment of time to answer this question here, and let his comments be reposted elsewhere if necessary by others, as this forum is far more active than AF.
Dr.Daemon is a very busy man, running his various business (www.synergy-solutions.org), and I think that he can probably only devote so much time to posting on the internet....it's probably best spent where there is the most possible traffic, with regards to this topic and others.
I think the members at EF are certainly capable of carrying on a robust discussion on this topic with myself and Dr.JD without going elsewhere. Lets keep the topic here.
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I need some clarification first on the following paragraph:
"Remember, Type 3 iodothyronine deiodinase (D3) is the physiologic INACTIVATOR of thyroid hormones and their effects (13), and is well known to have independent interaction with growth factors (which is what GH and IGF-1 are).(14) This is because with adequate T4 and excess T3, (D1 and D2) deiodinase is no longer needed for conversion of T4 into T3, but levels of D3 deiodinase will be elevated. When there is less of the first two types of deidinase, it would seem that the T3 which has been converted to T4 can not exert it’s protein sparing (anabolic effects), as those first two types are responsible for mediation of many of the effects T3 has on the body. This seems to be one of the ways deiodinase contributes to anabolism in the presence of other hormones."
Is that a typo where it states, "When there is less of the first two types of deidinase, it would seem that the T3 which has been converted to T4 can not exert it’s protein sparing (anabolic effects),...."
To my understanding, Once T3 is established/created, it cannot be converted back to T4. Did you mean to state "T3 which has been converted FROM T4...."...?
Not trying to be picky here....but rather just trying to clarify.
BMJ
"Remember, Type 3 iodothyronine deiodinase (D3) is the physiologic INACTIVATOR of thyroid hormones and their effects (13), and is well known to have independent interaction with growth factors (which is what GH and IGF-1 are).(14) This is because with adequate T4 and excess T3, (D1 and D2) deiodinase is no longer needed for conversion of T4 into T3, but levels of D3 deiodinase will be elevated. When there is less of the first two types of deidinase, it would seem that the T3 which has been converted to T4 can not exert it’s protein sparing (anabolic effects), as those first two types are responsible for mediation of many of the effects T3 has on the body. This seems to be one of the ways deiodinase contributes to anabolism in the presence of other hormones."
Is that a typo where it states, "When there is less of the first two types of deidinase, it would seem that the T3 which has been converted to T4 can not exert it’s protein sparing (anabolic effects),...."
To my understanding, Once T3 is established/created, it cannot be converted back to T4. Did you mean to state "T3 which has been converted FROM T4...."...?
Not trying to be picky here....but rather just trying to clarify.
BMJ
In regards to the following....
"So when there is an excess of T3 in the body (but levels of T4 are normal), the body’s thyroid axis sends a negative feedback signal. This produces less (D1 and D2) deiodinase, but more of the D3 type, which signals the cessation of the T4-T3 conversion process, and is inhibitory of many of the synergistic effects that T3 has!"
Ok, I understand this.
Now, for further clarification, are you stating that GH is going to increase the D1/D2-deiodinase enzymes to help create more T3?
BMJ
"So when there is an excess of T3 in the body (but levels of T4 are normal), the body’s thyroid axis sends a negative feedback signal. This produces less (D1 and D2) deiodinase, but more of the D3 type, which signals the cessation of the T4-T3 conversion process, and is inhibitory of many of the synergistic effects that T3 has!"
Ok, I understand this.
Now, for further clarification, are you stating that GH is going to increase the D1/D2-deiodinase enzymes to help create more T3?
BMJ
Cauliflower Ear
New member
I Am very lost...so t3 or t4 with gh... 
...actually i think i am just going to avoid them both
...actually i think i am just going to avoid them both
L
lartinos
Guest
I am very sensitive to stims as well guys, I can't even handle diet pills including trex. T3 works great for me because it isn't stimulant. I'm sure t4 would work well for me too.
A
Anthony Roberts
Guest
I don't think so...
