yeah you will need to monitor hematocrit. Pro cyclists stay around 50 too be safe, also have a team dr. around 24/7 monitoring them i think epo is out of the avg guys realm too use safely. BP, HR, too many things need to monitered all the time. Also i have read that on EPO your heart can fall too dangerous levels when sleeping, so guys have worn a heart rate monitor during bed with an alarm ata certain heart rate. All too much! pass on it!