Just this..... You just don't want to wake up with itchy puffy nipples, or in the ICU, or some other shit....
But once the neddle is in position you just forget about everything...
ummm high blood pressure due to water retention (can be taken care of with n-dex, l-dex, a-dex, etc.) The likeliness of getting an infection due to dirty gear. Gyno, night sweats, little anxiety, high liver values. These are all ones I've personally experienced. But to me, the pro's outweight the con's by ten fold.