To be honest, I have not used it.
But that is the dosing protocol, and taking at all at once with not be beneficial. Im asuming your doing an oral cycle, and since orals have a short have life you need to spread them out aswell. Taking the N2guard throughout the day will provide consistant release whereas taking them all at once - they will be out of your system within a few hours and it will be too much for your liver to take all of it, most would be wasted. Take them with and between the orals.
Hope that helps