Does GH really increase internal organs?

[hardone899]

My friend is a doc and told me never to use gh because it increases the size of your internal organs. Is this true? I am just 26 yeras old. Should I just stick to gear and use gh when I get older? I have really really shitty genetics! Thanks, jay

 

[OAKBOX]

HGH makes everything grow, including your organs and heart. Start small, as the effects of GH are permanent.

 

[drveejay11]

Wait till you're older bro......it's a whole different animal you are dealing with

 

[SUST-MAN]

I hear it adds 2.2 inches to the length....and 1.6 inches of girth to your penis....

 

[ironmaster]

Your doc is reiterating a non-proven theory about the use of exogenous GH.
Several studies have found an increase in BODY mass after a cycle of rHGH, but not an increase in Muscle mass (no steroids, non-weight trained individuals).
Different researchers offer different explanations. One is that internal organs gained mass. More likely it's a combination of fluid retention, thickening of connective tissue, and increased bone density. Studies support these explanations.......no study has ever measured the effects of GH on internal organs.
Oh, of course there is SUST-MAN's theory, which I prefer.....

 

[nandi12]

Several studies have found an increase in BODY mass after a cycle of rHGH, but not an increase in Muscle mass (no steroids, non-weight trained individuals).

This is true, but studies have indirectly shown (by measuring protein synthesis) that GH does cause an increase in muscle protein synthesis but not whole body (organ) protein synthesis (see below). These studies were short term, done over a period of a few hours.

This contradicts longer term studies (14 days) in humans that have shown no change in protein synthesis due to GH treatment (1).

Rats that overexpress either GH or IGF-1 show enhanced growth of the intestines (2). The intestines are particularly rich in GH receptors. "GH belly" may be due to increased intestinal growth more than growth of other organs.

Metabolism 1993 Sep;42(9):1223-7
Growth hormone acutely stimulates skeletal muscle but not whole-body protein synthesis in humans.
Fryburg DA, Barrett EJ.

In a previous study, a 6-hour local infusion of growth hormone (GH) into the brachial artery of normal subjects stimulated net muscle protein anabolism by augmenting skeletal muscle protein synthesis. In the present study, we examined whether systemically infused GH affects forearm and whole-body protein metabolism. Normal volunteers aged 18 to 24 years (n = 8) were given an 8-hour systemic infusion of 3H-phenylalanine and 14C-leucine. Between 90 and 120 minutes of tracer infusion, basal samples for determination of forearm and whole-body amino acid kinetics were taken. GH was then infused at 0.06 micrograms/kg/min, increasing GH concentration from 2.4 +/- 0.3 to 32 +/- 3 ng/mL. Systemic insulin-like growth factor 1 (IGF-1) level increased from 224 +/- 20 to 262 +/- 21 ng/mL (basal v 6-hour, P < .01). By 6 hours, GH suppressed forearm phenylalanine and leucine net release (each P < .05) by increasing 3H-phenylalanine (66%, P < .05) and 14C-leucine (13%, P < .05) extraction or disposal (Rd). Whole-body leucine rate of appearance ([Ra] an index of whole-body proteolysis) and nonoxidative leucine Rd (whole-body protein synthesis) did not change over the course of the GH infusion, whereas oxidative leucine Rd decreased (20%, P < .03). Acute stimulation of muscle but not whole-body protein synthesis by systemically infused GH suggests that muscle protein is acutely and specifically regulated by GH.

(1) J Appl Physiol 1993 Jun;74(6):3073-6
Short-term growth hormone treatment does not increase muscle protein synthesis in experienced weight lifters.
Yarasheski KE, Zachweija JJ, Angelopoulos TJ, Bier DM.

(2) Gastroenterology 1997 Feb;112(2):444-54
Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I.
Ohneda K, Ulshen MH, Fuller CR, D'Ercole AJ, Lund PK.

 

[Hugh Gellatts]

"I hear it adds 2.2 inches to the length....and 1.6 inches of girth to your penis...."


you forgot to mention the necessity of injecting it straight into the snake's eye though.

 

[supergirl]

Oh, of course there is SUST-MAN's theory, which I prefer.....

hey DAD... are you forgetting that your daughter reads this shit too!!! heheheee...

I MISS YOU!!! we need to talk...

and as far as gh on internal organs... everything i have ever read "suggests" that theory.. but i have still not read any substantiated hard data proving it so....

 

[SofaGeorge]

hey DAD... are you forgetting that your daughter reads this shit too!!! heheheee...

I MISS YOU!!! we need to talk...

and as far as gh on internal organs... everything i have ever read "suggests" that theory.. but i have still not read any substantiated hard data proving it so....

Just talk to any surgeon that lives in LA and they will tell you that GH definitely messes up peoples internal organs.

 

[gambit7666]

Just look at today's pro's and their disgustingly disdended stomachs. there is your answer

 

[KnoXville]

coleman - kovaks

 

[XCYTER]

Now isnt it true that GH increases the number of muscle cells? Something AAS cannot do???
They only cause muscle cell hypertrophy????

 

[KA-BAR]

I hear it adds 2.2 inches to the length....and 1.6 inches of girth to your penis....

If this is true Ill be ordering some of that shit tonight.

 

[NFG123]

My friend is a doc and told me never to use gh because it increases the size of your internal organs. Is this true? I am just 26 yeras old. Should I just stick to gear and use gh when I get older? I have really really shitty genetics! Thanks, jay

This is true.

NFG

 

[ironmaster]

Nandi12......always intelligent stuff from you! So, I think you are saying that you agree with me.....at least the 2 of the studies you cited (Yarasheski and Barrett) find that whole body protein synthesis is not affected by exogenous GH.
Actually, in Yarasheski's more recent studies (published in the same journal) he states that "lean body mass was increased, but again, this wasn't muscle mass, but probably a combination of water retention, organ mass, and connective tissue instead."
The real answer to the "gut" issue may lie in the relationship between GH and IGF-1 as is suggested in the "mice" study you mentioned. As Ney states in his 1999 study, in addition to the systemic effects of liver IGF-1, IGF can act locally. GH binding to cells can lead to what is called peripheral conversion of IGF-1. At this specific location (skeletal muscle for example), IGF-1 acts in an autocrine or paracrine fashion to promote its effects. This means that unlike GH, which has endocrine function (it is produced in the pituitary and travels elsewhere to do its work), IGF-1 can both be produced in, and promote changes in, the same tissue or those immediately adjacent to it.
Perhaps the most relevant effect of IGF-1 is the ability of IGF-1 to increase protein synthesis by increasing cellular mRNA formation (mRNA makes protein) as well as increasing uptake of amino acids. This effect on protein synthesis can lead to increased lean mass. The research indicates that this effect is dependent on GH presence as well. So IGF-1 alone does not promote such effects. Nor does GH. It appears the combination of the two most consistently lead to increased protein synthesis.
One thing is for sure....the research is contradictory.