Do steroids help reduce myostatin?

[poompoom]

I heard people say our potential is limited by myostatin, to overcome our limitation we must use steroids, does that mean steroids help reduce myostatin?

 

[bonacris]

They don't reduce it but by adding a powerful compound or upping the dose you can overcome it temporarily allowing for extra gains in a cycle

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[EZ_E]

Something that has worked for me regarding this is bumping up my dose about half way into the cycle....More specifically; I run 8-weekers and always use prop as a base, so I'd start @ 300 mg's a week for the 1st half & bump to 350 mg's for the 2nd half-the end......

 

[John Juan]

Yes, anabolic steroids inhibit Myostatin by increasing follistatin levels invivo. This pubmed study from last year proves it.

Modulation of follistatin and myostatin propeptide by anabolic steroids and gender.

AuthorsMosler S, et al. Show all Journal
Int J Sports Med. 2013 Jul;34(7):567-72. doi: 10.1055/s-0032-1312585. Epub 2013 Apr 4.

Affiliation
Abstract
The purpose of this pilot study was to investigate the impact of training, anabolic steroids and endogenous hormones on myostatin-interacting proteins in order to identify manipulations of myostatin signalling. To identify whether analysis of the myostatin interacting proteins follistatin and myostatin propeptide is suitable to detect the abuse of anabolic steroids, their serum concentrations were monitored in untrained males, bodybuilders using anabolic steroids and natural bodybuilders. In addition, we analysed follistatin and myostatin propeptide serum proteins in females during menstrual cycle. Our results showed increased follistatin concentrations in response to anabolic steroids. Furthermore, variations of sex steroid levels during the menstrual cycle had no impact on the expression of follistatin and myostatin propetide. In addition, we identified gender differences in the basal expression of the investigated proteins. In general, follistatin and myostatin propeptide concentrations were relatively stable within the same individual both in males and females. In conclusion, the current findings provide an insight into gender differences in myostatin-interacting proteins and their regulation in response to anabolic steroids and endogenous hormones. Therefore our data provide new aspects for the development of doping prevention strategies.

© Georg Thieme Verlag KG Stuttgart · New York.

 

[RickRock13]

Steroids actually increase myostatin in the body, and it will actually reach peak around week 8 of a cycle, which is why gains typically stall out around that time. To overcome it and make more gains at that point would require a higher dose and/or some more anabolic/androgenic compounds which would allow more gains for a short amount of time. In the end the body always wins, which is why you must come off of high doses to baseline myostatin and resume muscle gain again.

You will see from this study, that testosterone administration affects myostatin levels considerably as it was much higher than baseline at day 56 (week 8)

Measurement of myostatin concentrations ... [Mol Cell Endocrinol. 2009] - PubMed - NCBI