DNP, Rebound Effect?

[becomingthewarrior]

I was talking to a guy who is very knowledgable on AAS and he said its impossible to keep DNP fat loss, because are body has a "negative feedback loop." So basically b/c ur body on DNP loses fat so fast its impossible to keep it off, your body will produce chemicals to make you gain that weight back.

I say all this to ask. DNP is unmatched in terms of initial fat loss, so has anyone used DNP and actually kept the fat off?

 

[hurricane]

i never gained back fat off it .. i cant agree with that ..

 

[daveyboy2345]

dnp is non hormonal and there is 0 chance of any rebound.

 

[needtogetaas]

I think nelson knows a lot about this.

 

[eddymerckx]

you will only gain back the fat w/excess calories...what you gain back is all the the water lost---what is so important that everyone forgets is that the scale means nothing in the gear world--only the mirror is an accurate gauge.

 

[sensational]

You drop water after getting off of DNP so you should lose a bit of weight after discontinuing. As far as rebound, there shouldn't be any as far as fat gain, I have heard of purported anabolic rebound, and I notice this effect myself.

There are rumors that it downregulates the thyroid due to stress on your body, a la how your thyroid slows down when you are calorie depleted and doing a lot of cardio while cutting. This is likely just transient and the thyroid should return to normal quickly, if indeed it does down regulate. But I believe this to be highly dependent on dosage as well as duration of the DNP cycle as well.

Personally, DNP has made huge improvements in my physique. It was hard to deal with the lethargy (offset somewhat by ECA) and the constant sweating (annoying as hell). And certainly messed with my psyche because I just simply couldn't train as hard.

Be safe man, as DNP is not a substance to be used lightly.

 

[Tatyana]

It is not a miracle drug, it is actually quite a dangerous drug in the wrong hands.

Of any BBing drug, and I use 'BBing drug' loosely as it is really an industrial chemical, there are people that die from using it every year.

I have heard other FBBers say they gained back all the fat even with diet and cardio in check.

Like any drug, there is not any standard response, you can't just say, well that didn't happen for me so it won't happen to you.

If that was the case, there would never be any adverse drug reactions with typically prescribed drugs, but we know this is the case.

Here is an example that I just read this morning with anti-depressants in the British Medical Journal (Cytochrome P450 genotyping and antidepressants) April 2007

- 1/3 of people will have a complete recovery

-1/3 of people will show substantial improvement

-1/3 of people are non-responders

In every one of these groups, there is a smaller sub-set(group) that will get the sides of sexual dysfunction, weight gain, insomnia and nausea.

And there is no way of telling how patients will respond.

The article follows: Similar concerns exist for MANY DRUGS not just anti-depressants.


Cytochrome P450 is a part of the electron transport chain, which is where ATP is made in the mitochondria, and also where a lot of drug detoxification happens.

Your liver cells have the most mitochondria of any cell in the body.

What does DNP do? It is a ATP un-coupler, I would have to look up the specifics again.

This is the trippy thing about mitochondria, they have their own DNA that makes all these bits to make energy, detoxify drugs and also this is where fatty acids are oxidised (used for energy).

Pharmacology is really quite complicated, so what happens with one person is NOT EVIDENCE of what might happen to you.

I might be rambling a bit, I was on-call last night and didn't sleep.

My point is, I personally think this is a drug of desperation, and you have to be a bit bonkers to take it.






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[GUARDIAN]

i thought we weren't to discuss DNP anymore on here bc it was so dangerous? mav????

 

[Tatyana]

dnp is non hormonal and there is 0 chance of any rebound.

It is not like your hormones are separate in your body, everything has an impact.

Changing metabolism in your body is going to have your endocrine system respond.

It is all interconnected and inter-related.

 

[hurricane]

i thought we weren't to discuss DNP anymore on here bc it was so dangerous? mav????

sorry to speak my mind but thats just stupid .. yes it is a dangerous compound but its used by many and imo is safe if used correctly, others might disagree but no matter what your opinion, people who use gear know about it and are goin to use it if they choose .. all this ban discussion will do is 1) drive them to another board seeking advise or 2)lead them blindly into using it without proper education .. which is more dangerous

 

[Tatyana]

sorry to speak my mind but thats just stupid .. yes it is a dangerous compound but its used by many and imo is safe if used correctly, others might disagree but no matter what your opinion, people who use gear know about it and are goin to use it if they choose .. all this ban discussion will do is 1) drive them to another board seeking advise or 2)lead them blindly into using it without proper education .. which is more dangerous

That's your opinion. ARe you an organic chemist? A medical doctor?

Or are you someone who has used the drug safely in the last year or two?

DNP depletes glutathione, which is one of the major anti-oxidants in the body.

It is known to cause DNA adducts, which is a bit of DNA bound to a (carcinogenic*) chemical.

*There have been no studies as to whether or not DNP is carcinogenic or mutagenic, but seriously, is a bit of weight loss now which is not permanent for most people worth increasing your risk of cancer?

Who was it on this board who is now banned that went through a DNP cycle in November and then by February was talking about how he had to lose weight again?

He didn't even know how many calories he was taking in during the day. BONKERS and irresponsible.

You can't just look at the short term weight loss.

I know someone else who rants as much as I do about this drug, he has a doctorate in neuroscience and he is a jooser.

Me, biochemical pathways and metabolism rock my world.

I am going to do more research, but I wouldn't be surprised if some of the effects of DNP were to set up apotosis of mitochondria, which, in the long term is going to slow your metabolic rate.

 

[hurricane]

That's your opinion. ARe you an organic chemist? A medical doctor?

Or are you someone who has used the drug safely in the last year or two?

DNP depletes glutathione, which is one of the major anti-oxidants in the body.

It is known to cause DNA adducts, which is a bit of DNA bound to a (carcinogenic*) chemical.

*There have been no studies as to whether or not DNP is carcinogenic or mutagenic, but seriously, is a bit of weight loss now which is not permanent for most people worth increasing your risk of cancer?

Who was it on this board who is now banned that went through a DNP cycle in November and then by February was talking about how he had to lose weight again?

He didn't even know how many calories he was taking in during the day. BONKERS and irresponsible.

You can't just look at the short term weight loss.

yes and if u scroll up .. i said it is my opinion ..strongly advising people to stay away from it is totally understandable .. but barring the discussion?perhaps we should bar the discussion on hgh because it has been linked to cancer growth by some .. also maybe bar insulin discussion and ephera discussion also .. shyt might as will ban orals while u at it also ...they pretty hard on the liver ..all this stuff is dangerous .. prop education on using this stuff is more valuable then a ban..wat people come here for ..not the hiding of it

 

[Tatyana]

yes and if u scroll up .. i said it is my opinion ..strongly advising people to stay away from it is totally understandable .. but barring the discussion?perhaps we should bar the discussion on hgh because it has been linked to cancer growth by some .. also maybe bar insulin discussion and ephera discussion also .. shyt might as will ban orals while u at it also ...they pretty hard on the liver ..all this stuff is dangerous .. prop education on using this stuff is more valuable then a ban..wat people come here for ..not the hiding of it

I understand your point, but it is also really not on saying 'it is safe'.

It is not a safe drug.

You can't really call any drug 'safe'.

To call this drug 'safe' is especially dangerous.

 

[sensational]

People will think I am stupid because I have used DNP and will probably use it again, it does not mean i am not intelligent. It means that I have measured a calculated risk, tried to minimize the risk, then taken it.

This does not imply lower intelligence, maybe negligence, but not stupidity.

 

[Tatyana]

People will think I am stupid because I have used DNP and will probably use it again, it does not mean i am not intelligent. It means that I have measured a calculated risk, tried to minimize the risk, then taken it.

This does not imply lower intelligence, maybe negligence, but not stupidity.

I don't think anyone said anything about stupidity or lower intelligence.

I did say that I thought anyone that took it was bonkers, and that it was a drug of desperation.

 

[jnef]

yes and if u scroll up .. i said it is my opinion ..strongly advising people to stay away from it is totally understandable .. but barring the discussion?perhaps we should bar the discussion on hgh because it has been linked to cancer growth by some .. also maybe bar insulin discussion and ephera discussion also .. shyt might as will ban orals while u at it also ...they pretty hard on the liver ..all this stuff is dangerous .. prop education on using this stuff is more valuable then a ban..wat people come here for ..not the hiding of it

Excellent Post hurricane, we should no be censored on educating ourselves

 

[sparetire]

I believe and know for a fact that there are always risks from any medication. Sure, I can say I'll take such and such drug risking the minimal side effects, but when the major side effect from DNP is DEATH, I think I'll pass. This is one drug that is way to risky to bet your life on losing a few pounds. It's an easy way to lose the fat and even easier to get 6 feet deeper much sooner. Maybe I'm paranoid, maybe I'm over-reacting, but who cares what your body fat is when your dead.

 

[jnef]

I believe and know for a fact that there are always risks from any medication. Sure, I can say I'll take such and such drug risking the minimal side effects, but when the major side effect from DNP is DEATH, I think I'll pass. This is one drug that is way to risky to bet your life on losing a few pounds. It's an easy way to lose the fat and even easier to get 6 feet deeper much sooner. Maybe I'm paranoid, maybe I'm over-reacting, but who cares what your body fat is when your dead.

yes but nobody is pushing dnp on you, people should be allowed to discuss it and make their own decision while researching. you sound like "big brother" remember you can also die from an asprin overdose.

 

[sparetire]

yes but nobody is pushing dnp on you, people should be allowed to discuss it and make their own decision while researching. you sound like "big brother" remember you can also die from an asprin overdose.

Where did I state in my opinion of Dnp that I said that it couldn't be discussed? I never stated that at all. I was simply giving my opinion as with everyone else who was sharing their opinions. I'm hardly big brother at all and it's quite ignorant of you to misread my initial response and gather your misconceptions from it. I was basically just saying that it's an extremely dangerous drug and there have been people on this forum who have died from it. It's pretty risky to gamble your life on vanity. I understand completely why one would want to take dnp - it's the easy way to lose fat, but you must ask yourself if the benefits outweigh the side effects, in which this case, is death. Go dose yourself on dnp, no one is stopping you. In fact, I don't really care if it's discussed here or not, I think that the more information people learn about dnp, the better. That way, they can decide on whether to take it or not with the certain risks.

And giving me your response of overdosing on asprin is a cop out to make your argument. You can die from overdosing on almost anything - IE - the word OVERDOSE implies that taking too much of something is harmful for you..duh. But this is like compairing apples to oranges with asprin and dnp. If someone deliberately od's on asprin/tylenol whatever, it's an obvious cry of depression - suicide, etc... OD'ing on dnp is most likely NOT from those reasons but from mistaken dosing, or just plain complications from the drug itself - which are very dangerous side effects. That's all I was saying, so if that's "big brother" to you, then you are obviously living in a different world.

 

[eddymerckx]

yes but nobody is pushing dnp on you, people should be allowed to discuss it and make their own decision while researching. you sound like "big brother" remember you can also die from an asprin overdose.

dnp is not safe to use—you can use it in manner that lowers the risk of death perm side effects.

to compare it to aspirin is flawed---the line between a therapeutic and a deadly dose is not comparable to dnp.

while asprin can be fatal in doses over 55,000 mg (88x-166x therapeutic dose) (assume 235lb man)

dnp can be fatal at 1g-3g* ( <1x-7x doses taken by bbs)

with a possibilty that the line between fat loss and death is less than 1x the dose taken and the product produced by an UG, how can that be even considered safe to take or being able to used in a safe manner by any stretch? esp when VVVVV

the signs and symptoms of acute poisoning are the same as expected for fat loss**

and btw, don't take asprin while on dnp***


*The fatal dose in adults is about 1 to 3 g by mouth, and 3 g has proved fatal even in divided doses over a period of 5 days. [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-157; The acute fatal dose of dinitrophenol /SRP: Unspecified mixture of isomers/ is approximately 1 g.[Dreisbach, R.H. Handbook of Poisoning. 11th ed. Los Altos, CA: Lange Medical Publications. 1983., p. 127}

**Signs and symptoms of acute poisoning in human beings include nausea, restlessness, flushed skin, sweating, rapid respiration, tachycardia, fever, cyanosis, and finally, collapse and coma. The illness runs a rapid course; death or recovery occurs within 24 to 48 hours. If production of heat exceeds the capacity for its dissipation, fatal hyperthermia may result. Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1691


***"Salicylates, which contain a phenolic group, must be avoided during treatment for exposure to dinitrophenols." [Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1691]

 

[Mavafanculo]

^^ The End