DNP and brain damage

[Rippeddrago]

well, I guess I'm deluding myself and I know I'm out of my mind. HOwever, DNP@250mg/day after spending countless hours reading and asking questions, and then buying and taking all the necessary supplements, I don't feel like this is one of the highly delusional things I've done. I'm reaching for the pinnacle of low bodyfat, and if doing cardio for an hour day 6x/week for 2mos beforehand is "lazy" by your definition... well I'm a bum then. Hey Densehead, do you take juice?? That's ok though right? T3, that's ok right? If you mess with that and screw up you could end up on meds for the rest of your life. It comes down to knowledge.... fool.

 

[FarBeyondDriven]

Re: Re: DNP and brain damage

brain damage occures only if you severly overdose on dnp, thats when your body temp raises too high hence the brain damage, but dont worry, if you OD to that extent you will most likely die anyway

needless to say doses of 600-800mg/ed will not cause brain damage of any sort

Nah I did 400 mg/day in 2 doses. 600 won't cause that. And yes I did countless hours of research, did not drink and no other drugs along with all the vita's and anti-oxi's. They told my mom that I had a 10% chance to live the first night and a 95% chance if I did I would be severly retarded. My body temp. went to 108. I am not dumb, graduated college afterwards, I am a miracle. You can give penicillin to some people and it cures them, it may kill others.

 

[smokinghawk]

Okay, you want science? Here you go.

DNP raises SURFACE body temperature, not CORE body temperature, so all this stuff about "melting your brains and organs" is utter nonsense. Even surface temp only raises by .5 degrees on average, and maybe 1-2 degrees on a larger dose (which, incidentally, HELPS the immune system in the same way a fever does, by making the body resistant to virus/bacterial reproduction).

DNP temp increases sufficient to cause brain damage occur only when people have done massively absurd doses, in which case they'll die anyway and we don't need 'em.We call those people "FDA fodder."

 

[ferris77]

OK, just my 2cents

First let me start by saying I feel something like this (formation of cataracts and skin lesions and has caused effects on the bone marrow, central nervous system (CNS), and cardiovascular system) in the medical enviroment is considered dangerous.

Now I'm no scientist, but I do have a BS degree in PA medicine. I have used 2,4, Di-nitrolphenol numerous times myself since reading about it years ago from a man I liked to think of as paving the way in getting shreded. "guru"

It does raise your surface temp, but when it uncouples oxygen at the cellular level and effects the take up of glucose interfering with you ATP process then it does have an afinity to raise the core temp also. (causing the profuse sweating of the hands, feet and head.)

Will it cause brain damage? NO if you don't abuse and overdose it, but it could cause worse with cancer!

So, anyways that's my two cents. Not worth more but maybe alittle something new.

 

[HighIntensity]

Re: OK, just my 2cents

First let me start by saying Now I'm no scientist,
Will it cause brain damage? NO if you don't abuse and overdose it, but it could cause worse with cancer!

what does this mean, your right doc you are no scientist, because with proper reading you would have come across the studies that say DNP does not cause cancer in fact it can help destroy it.

 

[Golfer18--old]

SUMMARY: Exposure to dinitrophenols occurs mainly from breathing air, drinking water, or eating food that contains the chemicals. At low levels, these chemicals may cause cataracts, serious skin rashes, and decreases in white blood cells. At high levels, these chemicals may cause increased heart and breathing rates, and even death. These chemicals have been found in at least 61 of the 1,430 National Priorities List sites identified by the Environmental Protection Agency (EPA).

What are dinitrophenols?
(Pronounced di-ni'tro-fee'nolz)

Dinitrophenols are a class of manufactured chemicals that do not occur naturally in the environment. There are six different dinitrophenols.

The most commercially important dinitrophenol, 2,4-di-nitrophenol (DNP), is a yellow solid with no smell. It is used in making dyes, wood preservatives, explosives, insect control substances, and other chemicals, and as a photographic developer.

It was used in diet pills in the 1930s but was banned for this use in 1938. It may be sold under several trade names, including Caswell No. 392, Sulfo Black B, and Nitro Kleenup. Use of trade names is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry, the Public Health Service, or the U.S. Department of Health and Human Services.

What happens to dinitrophenols when they enter the environment?

DNP enters the air, water, and soil during its manufacture and use.
It may be formed from reaction of other chemicals in the air.
DNP may also enter the environment through landfill and storage tank leaks, or accidental spills during manufacture or transport.
It dissolves slightly in water, and does not easily evaporate to air.
It can be broken down slowly in water and soil by small organisms or by reacting with other chemicals.
DNP sticks to particles in water, which will cause it to eventually settle to the bottom sediment.
DNP also sticks to some types of soil particles, which may prevent it from moving very deep into the soil with rainwater.
DNP probably does not build up significantly in fish.
How might I be exposed to dinitrophenols?

Breathing contaminated workplace air where it is manufactured or used.
Breathing contaminated air from DNP-containing waste sites, waste incineration, or automobile exhaust.
Touching contaminated soil or water near DNP-containing waste sites.
Ingesting contaminated soil or water near DNP-containing waste sites.
How can dinitrophenols affect my health?

Most of the information on the health effects of dinitrophenols comes from old studies of patients who were prescribed diet pills containing dinitrophenol before it was banned.

Deaths have occurred in people who ingested 3–46 milligrams of dinitrophenols per kilogram of body weight per day (3–46 mg/kg/day) for short periods, or 1–4 mg/kg/day for long periods. Also, people who breathed air containing 40 mg dinitrophenols per cubic meter of air (40 mg/m3) for long periods have died.

The amount of dinitrophenols ingested that causes harmful effects varies among people. Increased basal metabolic rate (the rate that you use energy at complete rest), increased sweating, a feeling of warmth, weight loss, and increased heart rate, breathing rate, and body temperature have been observed in people who swallowed as little as 1 mg/kg/day or as much as 46 mg/kg/day for short or long periods of time.

Ingesting 2–4 mg/kg/day DNP for short or long periods has caused cataracts in some people, while ingesting 1–4 mg/kg/day for short or long periods has caused skin rashes and decreases in white blood cells.

How likely are dinitrophenols to cause cancer?

The Department of Health and Human Services (DHHS), the International Agency for Research on Cancer (IARC), and the EPA have not classified dinitrophenols for carcinogenicity.

There are no studies available in people or animals on the carcinogenic effects of dinitrophenols.

Is there a medical test to show whether I've been exposed to dinitrophenols?

Tests are available that measure the amount of DNPs or their breakdown products in blood, urine, and samples of tissue from the body. However, these tests may require special equipment and may not be available in your doctor’s office.

Has the federal government made recommendations to protect human health?

The EPA recommends that not more than 70 parts of dinitrophenols per billion parts of water (70 ppb) be present in lakes or streams used for swimming.

The EPA lists DNPs as hazardous air pollutants (HAP) under the Clean Air Act. The EPA also requires that discharges or spills into the environment of 10 pounds or more be reported.

Glossary

Carcinogenicity: Ability to cause cancer.

CAS: Chemical Abstracts Service.

Cataract: A decrease in the transparency of eye lenses.

Evaporate: To change into a vapor or a gas.

Ingest: Take food or drink into your body.

Kilogram (kg): One thousand grams.

Milligram (mg): One thousandth of a gram.

Sediment: Mud and debris that have settled to the bottom of a body of water.
References

Agency for Toxic Substances and Disease Registry (ATSDR). 1995. Toxicological profile for dinitrophenols. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.



Use it right and it wont kill you........use anything wrong and it can kill you. Thats why the driving age keeps going up.....

 

[3Vandoo]

meeooo dddiioooddddd DNPPPPPPP fiiirrrrrrsssst ccccyyyllleeeeeeelost 17lbs on 14ays!! at 400mg cyrrrrrrrrrysssssssttttaaaaaaallllllllllll




aaahaaaaaahaaaaaaaa ssssoooooo doooo


As you can see I also lost 17lbs of my brain

 

[ferris77]

Thanx

Good backing "golfer". This was not a pissing contest highas a kite I mean intensity.

Just was passing and affirming that no brain damage would occur if not taken to the extreme.

Oh, by the way it's the PHENOL that classifies it as a carcenogenic. Read about that and see if it cures cancer?

 

[Fish]

If you knew the first thing about DNP you would not be here bashing us like the ignorant being you are. I would like to see you try and produce proof of how, in the right hands (that being, somebody who has spent countless hours reading up on the subject) DNP could be the least bit life-threatening.

I had spent countless hours reading up on the subject, and almost died. Just because you read on the boards you do not know how your body will react. I was fine at the .2 dose it took for a week, as a test to see if I was allergic. Then I went to a .6 dose for 3 days before my temp was 105 and I was unable to move.

I am not saying DNP is "bad" but to say it could not be "the least bit life-threatening" is a bit one sided. And the same kind of thinking that got you in trouble a week ago.


And I belive any temp over 103 "could" cause permant brain damage.

 

[HighIntensity]

Re: Thanx

Good backing "golfer". This was not a pissing contest highas a kite I mean intensity.

Just was passing and affirming that no brain damage would occur if not taken to the extreme.

Oh, by the way it's the PHENOL that classifies it as a carcenogenic. Read about that and see if it cures cancer?

time to get your ass handed to you

http://boards.elitefitness.com/forum/showthread.php?threadid=138664&highlight=cancer+dnp+studies

Is DNP safe?

Here's my research. This is AMAZING! Not only has not a single test found it to be carcinogenic, but test after tyest after test find that DNP actually ATTACKS cancer cells, and helps anti-cancer medications work better, and helps anti-leukemia medications work without destroying cell DNA, and suppresses tumor growth by 20-50%. The summaries are all right here, friends. Karma me up!

DNP is Ames negative, and does not promote tumors. See for yourself at http://toxnet.nlm.nih.gov/

http://www.epa.gov/ttn/atw/hlthef/dinitrop.html reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.

http://www.cyberiron.com/drugs/dinitrophenol.html reports on halth risks from external exposue. In other words, don’t get it in your eyes, or on your skin if you’re allergic. Pretty elementary stuff.

http://www.ebec2000.com/abstracts/056.htm This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.

http://www.zymed.com/pdf/04-xxxx/04-8300.pdf A PDF file about an antidote to DNP.

http://www.boehringer-ingelheim.es/...glesa/cap13.htm finds that DNP did not activate liver enzymes (MAT) associated with liver damage

"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.

"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know—it’s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst results being softened stools and gas).

"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as…2,4-dinitrophenol (DNP)."

"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out—DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure…"


"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.

Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it’s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer…fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP can be synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.

"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it’s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity…"

"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP’s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.

"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.

"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates—or disrupts—cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.

"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT (good ol’ DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect…"

"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide by neutering themselves. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."

"Autocatabolism of surface macromolecules shed by human melanoma cells." Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps melanoma cells die (autocatabolize) while other cells are unaffected.

http://www.geocities.com/byggdegstor/dnpforside - tons of research, including medical studies. Excerpts:

DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation © 1996 Robert Ames)

Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."

"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."

"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."

"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."

"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."

"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."


Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.


night