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too much DHT causes ED? Or the exact opposite?
Remember..I said "too much" DHT.
Remember..I said "too much" DHT.
DHT- True or False
- Thread starter Smokescreen
- Start date
LiquidPhire
New member
Carth said:
BUMP I am curious about this also
DHT is an aromatase inhibitor. If you have really high levels of DHT, it can drive your E2 (Estradiol) down. If you have too little E2, it will kill your libido.
This is how Proviron hardens you up. It raises DHT and indirectly lowers E2. I have seen this effect firsthand when using Test gel applied directly to the scrotum. It causes a massive increase in DHT due to high concentrations of 5-alpha reductase there. My DHT came back over twice the top of the normal range (166 on a range of 25-75) and my E2 was low.
R1
This is how Proviron hardens you up. It raises DHT and indirectly lowers E2. I have seen this effect firsthand when using Test gel applied directly to the scrotum. It causes a massive increase in DHT due to high concentrations of 5-alpha reductase there. My DHT came back over twice the top of the normal range (166 on a range of 25-75) and my E2 was low.
R1
r1 said:
But proviron works by reducing SHB G, thus preventing too much e from aromatizing. It shouldn't lower e below normal levels. That's different from a strong suicide inhibitor (dex, fem, etc) which can remove ALL estrogen with a high enough dosage.
So I'd say "no." Excess DHT would just make you herader and hornier. Then again, how much are we talking about?
I think you're right, Nelson. Proviron in general makes people horny when taken in normal amounts and it's been shown to raise DHT. It can't be overly suppressive of E2 or people wouldn't get horny on it. I'd be curious about what would happen if you took "too much" though...a rather loose term.
R1
R1
r1 said:
You are exactly right about the scrotal application of Testosterone. There is more 5a-reductase in the scrotum than aromatase, and this is why you get higher levels of DHT, compared to E2.
However, DHT is not an aromatase inhibitor. The reason your E2 went down was because your route of delivery.
DHT does have anti-estrogen action, but it is from DHT antagonizing the ER, not from it competitively binding with aromatase or reducing aromatase production. Its anti-estrogen action could best be compared to a SERM.
To answer the original question, you would have to take in enough DHT to inhibit production of natural T (thus inhibiting E2), in order for DHT to actually cause ED. This scenario is unlikely though as DHT is not a very powerful inhibitor at the hypothalamus or pituitary. So even if DHT is high, your likely to still produce enough E2 for sexual health.
-Pp
Proviron working like a SERM? I doubt it. Then why the hardons and not the killed libido like most get from clomid and nolvadex?
Vascular Freak
New member
I can't answer as scientiifc as Pp BUT i can say that too much of any ONE hormone will disturb libido, either in a good or bad way. with proviron 150mg did absoultely nothing but make my prostate ache, 50-75mg makes my libido increase.......i look at it as a 4-5 legged stool, if one leg (or hormone) is to much out range from the others it doesn't balance out and won't stand correctly...pun intended!!
Carth said:
Id didn’t say Proviron or DHT is a SERM, it just competes for the ER similar to a SERM thereby blocking estrogens action on the ER…. rather than acting as an aromatase inhibitor like arimidex or letrozol.
Remember Proviron and DHT are also acting on the AR, and that is why they are increasing libido and hardons.
-Pp
Carth said:
To answer the question yes it can, however not directly, but as a secondary effect without attempting to get to technical, here is why. An over abundance of DHT will cause us to stimulate acetylcholine/parasympathetic nervous functions excessively, resulting in the over production of sex hormones and neurotransmitters such as acetylcholine, dopamine and serotonin. Abundant and unusually amount of these hormones and neurotransmitters can cause the brain and adrenal glands to perform excessive dopamine-norepinephrine-epinephrine conversion and turn the brain and body functions to be extremely sympathetic. In other words, there is a big change of body chemistry which can cause ED among many other side effects like fatigue, hair loss, scrotum/testes pain.
Dr. Indy-
Thanks for the info Indy. I appreciate it.
nydj66 said:
Not at all, you're right. That should read "aromatase inhibitor." (I just corrected someone else about this very point and then got it backwards myself!)
Thanks for setting it straight.
