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DHEA good or bad
- Thread starter xariesj2x
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Selfcentor
New member
If your over 50 go for it
needtogetaas
New member
yes I know a lot about dhea...its a great sup..
DHEA is an immediate precursor to the critical androgens known as androstenediol and androstenetriol.20,21 These metabolites of DHEA are known to have powerful anti-catabolic and anti-cortisol activity by counteracting the muscle wasting and immuno-suppressive effects of cortisol.23,24 Both androstenediol and androstenetriol act as anabolic hormones and have been shown to enhance recovery and tissue repair from injury.24,25 Furthermore, DHEA, androstenediol and androstenetriol have been found to be potent enhancers of the immune system, by helping to fight off infection, protect against lethal radiation, and restore immunity during times of stress.26-29
Studies using DHEA with elderly subjects and HIV patients have also shown restoration of immune system activty by increasing the division of immune promoting cells.30,31,32 Its been proposed that this increesed division of immunogenic cells is a result of DHEA increesing the bioavailability of IGF-1 and enhancing cellular mitosis.31
DHEA's stimulation of IGF-1 activity is supported by other human trials.33,34 These studies have also revealed that DHEA can stimulate gh - growth hormone (somatropin) - release. Therefore, the increese in IGF-1 can be explained by the increase in GH, since GH is converted to IGF-1 in the liver. An explanation for the GH release can be explained here by Suarez et al. 2005,
"it can be inferred that DHEA may release GH in vivo by reducing somatotrope responsivenes to somatostatin, as well as by enhansing somatotrope sensitivity to GHRH."
In general terms, DHEA sensitizes the pituitary to GHRH and boosts the release of GH.34
The increase in GH and IGF-1 with DHEA supplementation has shown to have real world benefits in muscle growth, fat loss and muscle strength in various human studies.35,36,37 Besides having a direct effect on body composition, IGF-1 plays an important role in steroidogenic hormone production. Most notably, IGF-1 stimulates the conversion of cholesterol to pregnenolone, otherwise known as the rate limiting step in steroid hormone synthesis. Enhancement of steroidal synthesis by IGF-1 is accomplished by IGF-1's action upon the leydig cell and stimulation of CYP11A, 3b HSD, and StAR. 38,39,40 Direct stimulation upon the leydig cell from IGF-1 helps initiate the first steps in creating anabolic hormones such as androstenedione, androstenediol, and testosterone.
it can be suppressive if taken for to long but short use has lots of benefits.it works taken orally and works 10X better taken topically
DHEA is an immediate precursor to the critical androgens known as androstenediol and androstenetriol.20,21 These metabolites of DHEA are known to have powerful anti-catabolic and anti-cortisol activity by counteracting the muscle wasting and immuno-suppressive effects of cortisol.23,24 Both androstenediol and androstenetriol act as anabolic hormones and have been shown to enhance recovery and tissue repair from injury.24,25 Furthermore, DHEA, androstenediol and androstenetriol have been found to be potent enhancers of the immune system, by helping to fight off infection, protect against lethal radiation, and restore immunity during times of stress.26-29
Studies using DHEA with elderly subjects and HIV patients have also shown restoration of immune system activty by increasing the division of immune promoting cells.30,31,32 Its been proposed that this increesed division of immunogenic cells is a result of DHEA increesing the bioavailability of IGF-1 and enhancing cellular mitosis.31
DHEA's stimulation of IGF-1 activity is supported by other human trials.33,34 These studies have also revealed that DHEA can stimulate gh - growth hormone (somatropin) - release. Therefore, the increese in IGF-1 can be explained by the increase in GH, since GH is converted to IGF-1 in the liver. An explanation for the GH release can be explained here by Suarez et al. 2005,
"it can be inferred that DHEA may release GH in vivo by reducing somatotrope responsivenes to somatostatin, as well as by enhansing somatotrope sensitivity to GHRH."
In general terms, DHEA sensitizes the pituitary to GHRH and boosts the release of GH.34
The increase in GH and IGF-1 with DHEA supplementation has shown to have real world benefits in muscle growth, fat loss and muscle strength in various human studies.35,36,37 Besides having a direct effect on body composition, IGF-1 plays an important role in steroidogenic hormone production. Most notably, IGF-1 stimulates the conversion of cholesterol to pregnenolone, otherwise known as the rate limiting step in steroid hormone synthesis. Enhancement of steroidal synthesis by IGF-1 is accomplished by IGF-1's action upon the leydig cell and stimulation of CYP11A, 3b HSD, and StAR. 38,39,40 Direct stimulation upon the leydig cell from IGF-1 helps initiate the first steps in creating anabolic hormones such as androstenedione, androstenediol, and testosterone.
it can be suppressive if taken for to long but short use has lots of benefits.it works taken orally and works 10X better taken topically
needtogetaas
New member
not completely trueSelfcentor said:
nemesis 2027
New member
needtogetaas said:
I'm not quite in my 50's', but I am in my mid 40's..., and I have used it off and on through my 30's as well with 'seemingly' positive results.
Haven't used it for a while since I've tried gear.
Selfcentor
New member
My bad!! haha I always read it was for older men and it was one of the only "'prohormons" not banned in the ban a few years ago. Glad to know it works well!
needtogetaas said:
DHEA is a great supp but it's had two drawbacks -- one, oral absorbability. And two, it will increase both T and e. The topical application and aromatse inhibitors in Dermacrine make for a nice way to get the most out of DHEA.
needtogetaas
New member
true true and a 3rd is unpredictability.it works deferent with every one..Nelson Montana said:
dermacrine has used it combined with other ingredents to maxamize its good effects and nullify any of its side effects.
holy ghost
New member
I take 55mg 7-keto-dhea EOD.
we grow as a result of what we absorb, not what we eat.
we grow as a result of what we absorb, not what we eat.
