No, Dermacrine will not prevent shut-down. If anything, it will speed it up, though I ran it for 2 months, and noticed no suppression from it. Remember, it's purpose is to introduce exogenous hormones into your body (Pregnenolone and DHEA, which can turn into Test, DHT, etc), and once those are elevated, your HPTA responds by reducing signal to your testicles.
The only theoretical ways to reduce suppression, are by running HCGenerate concurrently with your Winny, and/or run a low dose of Naltrexone (5mg/day). A lot of people have had good success with putting a check on shut-down by running HCGenerate on-cycle, and there are more and more having success with Naltrexone, myself included.
As for gains, I am not quite sure about that. I was not running Dermacrine concurrently with anything else, and I did notice an increase in size, but I was not checking a scale at that time, it did most definitely help in my continuous body recomp.
Where this stuff really shines though, is gym motivation, energy, overall feel-good healthy feeling. And that, my friend, is pure gold.