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Author
Falanga V; Greenberg AS; Zhou L; Ochoa SM; Roberts AB; Falabella A; Yamaguchi Y
Title
Stimulation of collagen synthesis by the anabolic steroid stanozolol.
Appears In
JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 111, no. 6 (1998 Dec): 1193-7.
Abstract
There is evidence that anabolic steroids, which are derived from testosterone and have markedly less androgenic activity, promote tissue growth and enhance tissue repair; however, the mechanisms involved in their anabolic activities remain unclear. In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.625-5 microg per ml) had no effect on fibroblast replication and cell viability (p = 0.764) but enhanced collagen synthesis (p < 0.01) in a dose-dependent manner (r = 0.907). Stanozolol also increased (by 2-fold) the mRNA levels of alpha1 (I) and alpha1 (III) procollagen and, to a similar extent, upregulated transforming growth factor-beta1 (TGF-beta1) mRNA and peptide levels (p < 0.001). There was no stimulation of collagen synthesis by testosterone. The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta1. These findings point to a novel mechanism of action of anabolic steroids.
There was no stimulation of collagen synthesis by testosterone.
Might want to talk to your doc about a course of stanozolol. It is the only AAS to date that has been shown to have a positive effect on collagen synthesis. Personally, I'd work with your doc on this one or find one who will work with you. There may be other issues with Ehlers-Danlos, particularly if it involves the vascular system that may preclude you from using androgens and nandrolone may not be the best choice here. Keep us updated.
W6
Falanga V; Greenberg AS; Zhou L; Ochoa SM; Roberts AB; Falabella A; Yamaguchi Y
Title
Stimulation of collagen synthesis by the anabolic steroid stanozolol.
Appears In
JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 111, no. 6 (1998 Dec): 1193-7.
Abstract
There is evidence that anabolic steroids, which are derived from testosterone and have markedly less androgenic activity, promote tissue growth and enhance tissue repair; however, the mechanisms involved in their anabolic activities remain unclear. In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.625-5 microg per ml) had no effect on fibroblast replication and cell viability (p = 0.764) but enhanced collagen synthesis (p < 0.01) in a dose-dependent manner (r = 0.907). Stanozolol also increased (by 2-fold) the mRNA levels of alpha1 (I) and alpha1 (III) procollagen and, to a similar extent, upregulated transforming growth factor-beta1 (TGF-beta1) mRNA and peptide levels (p < 0.001). There was no stimulation of collagen synthesis by testosterone. The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta1. These findings point to a novel mechanism of action of anabolic steroids.
There was no stimulation of collagen synthesis by testosterone.
Might want to talk to your doc about a course of stanozolol. It is the only AAS to date that has been shown to have a positive effect on collagen synthesis. Personally, I'd work with your doc on this one or find one who will work with you. There may be other issues with Ehlers-Danlos, particularly if it involves the vascular system that may preclude you from using androgens and nandrolone may not be the best choice here. Keep us updated.
W6
