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Dbol & Grapefruit Juice- Does This REALLY Work???

Texas Ranger

New member
Guys, I seen the studies that show Grapefruit juice increases the effectiveness of some oral drugs. Does anyone have any practical experience using the combo? I'm planning on drinking 4oz of Grapefruit juice several times throughout the day with each dose of Dbol(25mgs ED). Who has tried it and liked or disliked it???
 
dont know the chemistry behind the thoery however I have heard great things about it,,, its soposed to be kind of like taking creatine with grap juice....its sopesed to make your body absorb more of the drug,,,,
 
iveheard it works i also heard of grapefruit extract supplements there was an article in some mag on this it sounds pretty good to me let me know how it works texas ranger and if i remember the mag i read it in ill post it for ya
 
I read that the flavanoids in Grapefruit,(not sure about the juice), prevent the liver from breaking down horomones in your body, such as Var and Dbol, in essence, allowing it to stay in your body for longer.
 
Thought you may like this.

Really can not remeber where it came from but had it saved as good info

Name: Grapefruit

Scientific Name: Citrus paradisi

Grapefruit is believed to be native to Jamaica. Grapefruit trees were planted in Florida in the early 19th century. The United States is the largest producer of grapefruit in the world.

PROPERTIES
High in vitamin C and potassium.
A good source of folate, iron, calcium, and other minerals.
Pink and red varieties are high in beta carotene, a precursor of vitamin A.
High in fiber, low in calories.


PECTIN
Grapefruit contains pectin (found in the pulp/rind), a form of soluble fibre that can bind to cholesterol.
In a 16-week double-blind, crossover (placebo or pectin) study using 27 human volunteers screened to be at medium to high risk for coronary heart disease due to hypercholesterolemia, grapefruit pectin supplementation decreased plasma cholesterol by 7.6% and low-density lipoprotein cholesterol by 10.8%. The study did not interfere with the subjects' current diet or lifestyle. (1)

In animal studies, grapefruit pectin inhibited the formation of atherosclerosis. Animals fed a high fat diet plus grapefruit pectin had 24% narrowing of their arteries, while animals fed only the high fat diet had 45% narrowing. (2)


LYCOPENE
Lycopene is a powerful antioxidant, it is the pigment found in fruits and vegetables, providing the colour of tomatoes (which are the best source of lycopene), water melon and pink/red grapefruit.

There is some evidence that a diet high in lycopene may reduce the risk of prostate cancer, according to the first epidemiological study on this, conducted at Harvard University,

Men who ate a diet rich in tomato sauce, ketchup or other tomato-based products containing the powerful antioxidant known as lycopene were up to one third less likely to develop the disease. (3)

Although there are no double-blind studies on lycopene at present, the results of observational studies are promising and further research is needed.


GRAPEFRUIT JUICE DRUG INTERACTIONS
This food-drug interaction was actually discovered by accident. A study that was intending to test the interaction of alcohol and a blood pressure medication, used a mixture of alcohol with grapefruit juice to disguise the taste of alcohol for the study. Ironically, alcohol had no effect on the tested medication, but the grapefruit juice seemed to enhance the absorption of the drug. (4)

The researchers then confirmed the finding by comparing drug levels when taken with either grapefruit juice or water and found five-fold higher blood levels of the drug when it was taken with juice. Orange juice did not show this effect.

Grapefruit juice inhibits a special enzyme (CYP3A4) in the intestines that is responsible for the natural breakdown and absorption of many medications. When the action of this enzyme is blocked, the blood levels of these medications increase, which can lead potentially toxic side effects from the medications.

Research has suggested that flavonoids and/or furanocoumarin present in Grapefruit are the substances that act to block the enzyme in the intestines that normally metabolizes many drugs.

Some medications that interact with grapefruit juice: (5)

Statins (Cholesterol Lowering Drugs)
Antihistamines: Terfenadine
Calcium Channel Blockers (Blood Pressure Drugs):
Anti-convulsant: Tegretol (Carbamazepine)
Anxiolytics: Valium (Diazepam)
Anti-depressant: Sertraline Clomipramine
Cortico-steroids: Methylprednisolone
Oestrogens: Ethinyl estradiol
Anabolic Steroids: Dianabol
Impotence Drug: Viagra

Although some drugs are given with others to enhance their effects, grapefruit juice should not be used for this purpose because its impact can be unpredictable and potentially dangerous.

The above list is by no means exhaustive. Please consult with your doctor or pharmacist regarding possible interactions between grapefruit juice and medications you may currently be taking if you consume grapefruit/ juice regularly..


THE GRAPEFRUIT DIET
Most serious dieters at one time or another have been told to eat grapefruit. Proponents of the Grapefruit Diet believe that grapefruit contains a special fat-burning enzyme.

The Grapefruit Diet, originally called the Hollywood Diet, started in the 1930s and has come back in various forms many times since then. Dieters on this diet are permitted a few vegetables, tiny amounts of protein and lots of grapefruit.

The only study conducted into Grapefruit Diets was performed by Johns Hopkins University in Baltimore, and interestingly on behalf of and sponsored by the Florida Citrus Department!

The 13 week diet study consisted of 45 adults with a BMI of 30 kg/m (termed obese) seeking weight loss. All patients were placed on a low-calorie, low-fat diet which was designed to produce an average weight loss of 1-2 pounds per week. All subjects were asked to consume two servings of Florida grapefruit or grapefruit juice each day. (6)

This study, wasn't particularly valuable in proving whether grapefruit works as a weight-loss aid. There was no control group of people who didn't eat any grapefruit and the weight loss experienced by the participants could perfectly be explained by putting any obese person on a low calorie diet, regardless of whether grapefruit was included or not.

The reason that Grapefruit Diets work, as with many other fad diets is because dieters simply limit their caloric intake to less than 900 calories a day. As soon as you come off the diet, you will gain weight again because firstly these diets do nothing to change long term eating habits and secondly the body interprets a crash diet so low in calories as starvation, hence the body compensates by slowing down metabolism to conserve all available energy. This lowered level of metabolism makes future weight loss much more difficult.


In summary grapefruit has no active properties that burn up fat. It is a healthy, high in fibre and low in calorie food that makes a good addition to any healthy diet as should other fruits and vegetables.


References:

(1) The effects of grapefruit pectin on patients at risk for coronary heart disease without altering diet or lifestyle.

Cerda JJ, Robbins FL, Burgin CW, Baumgartner TG, Rice RW.
Department of Medicine, University of Florida College of Medicine, Gainesville 32610. Clin Cardiol. 1988 Sep;11(9):589-94


(2) Inhibition of atherosclerosis by dietary pectin in microswine with sustained hypercholesterolemia.

Cerda JJ, Normann SJ, Sullivan MP, Burgin CW, Robbins FL, Vathada S, Leelachaikul P.
Department of Medicine, University of Florida College of Medicine, Gainesville.Circulation. 1994 Mar;89(3):1247-53.


(3) A prospective study of tomato products, lycopene, and prostate cancer risk.

Giovannucci E, Rimm EB, Liu Y, Stampfer MJ, Willett WC.
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.J Natl Cancer Inst. 2002 Mar 6;94(5):391-8.

(4) Grapefruit juice-drug interactions.
Bailey DG, Malcolm J, Arnold O, Spence JD.
Department of Medicine, London Health Sciences Centre, Ontario, Canada.Br J Clin Pharmacol. 1998 Aug;46(2):101-10. .

(5) http ://secure.pharmacytimes.com/lessons/200303-02.asp

(6) Johns Hopkins University Weight Management Centre and Florida Dept. of Citrus, P.O. Box 148, Lakeland, FL 33802.


Wrongun!
 
Grapefruit juice down regulates the expression of some specific cytochrome P450 enzymes in the gut. Cytochrome P450 is a mixed function oxidase responsible for metabolizing certain drugs.


I'm not sure if var and d-bol are metabolized by the cytochrome P450s. If not grapefruit would have no effect on their function.
 
Wrongun, you posted right before me. Indeed I see d-bol on the list.


Anyone wishing to try to get more bang from their bol with grapefruit needs to keep in mind that the enzyme limiting effect lasts up to 24 hours.
 
Watch yourself with it. Again, the enzyme limiting effect lasts up to 24 hours. This can mean an overacumulation of the drug.
 
Many Many threads on this bros...

From what I remember GFJ helps with the uptake of MANY oral medications as it reduces some liver enzymes that would otherwise break down the medication...
 
jh1 said:
Many Many threads on this bros...

From what I remember GFJ helps with the uptake of MANY oral medications as it reduces some liver enzymes that would otherwise break down the medication...



say some one is rocking 25 mg of d bol ED how GF juice would u recomend one drink
'




thanks




:)
 
scientific evidence:

Eur J Clin Nutr. 2004 Jan;58(1):1-9. Related Articles, Links


Food-drug interaction: grapefruit juice augments drug bioavailability--mechanism, extent and relevance.

Dahan A, Altman H.

Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel.

More than a decade has passed since it was unintentionally discovered that grapefruit juice interacts with certain drugs. The coadministration of these drugs with grapefruit juice can markedly elevate drug bioavailability, and can alter pharmacokinetic and pharmacodynamic parameters of the drug. The predominant mechanism for this interaction is the inhibition of cytochrome P-450 3A4 in the small intestine, resulting in a significant reduction of drug presystemic metabolism. An additional mechanism is, presumably, the inhibition of P-glycoprotein, a transporter that carries drug from the enterocyte back to the gut lumen, resulting in a further increase in the fraction of drug absorbed. Some calcium channel antagonists, benzodiazepines, HMG-CoA reductase inhibitors and cyclosporine are the most affected drugs. A single exposure to one glass of the juice can usually produce the maximal magnitude of the interaction. The data available so far, concerning this interaction and its clinical implications, are reviewed in this article. It is likely that more information regarding this interaction will accumulate in the future, and awareness of such is necessary for achieving optimal drug therapy.

PMID: 14679360 [PubMed - in process]
 
: Steroids. 1995 Apr;60(4):353-66. Related Articles, Links


Metabolism of anabolic steroids in humans: synthesis of 6 beta-hydroxy metabolites of 4-chloro-1,2-dehydro-17 alpha-methyltestosterone, fluoxymesterone, and metandienone.

Schanzer W, Horning S, Donike M.

Institut fur Biochemie, Deutschen Sporthochschule Koln, Germany.

Hydroxylation at position 6 beta testosterone I (17 beta-hydroxyandrost-4-en-3-one) and the anabolic steroids 17 alpha-methyltestosterone II (17 beta-hydroxy-17 alpha-methylandrost-4-en-3-one), metandienone III (17 beta-hydroxy-17 alpha-methylandrosta-1,4-dien-3-one), 4-chloro-1,2-dehydro-17 alpha-methyltestosterone IV (4-chloro-17 beta-hydroxy-17 alpha-methylandrosta-1,4-dien-3-one), and fluoxymesterone V (9-fluoro-11 beta, 17 beta-dihydroxy-17 alpha-methylandrost-4-en-3-one) was achieved via light-induced autooxidation of the corresponding trimethysilyl 3,5-dienol ethers dissolved in isopropanol or ethanol. The reaction further yielded the 6 alpha-hydroxy isomer in low amounts. The 6 beta-hydroxy isomer of I-V and the 6 alpha-hydroxy isomers of I, III, and IV were isolated and characterized by 1H and 13C NMR, high-performance liquid chromatography, gas chromatography, and mass spectrometry. Human excretion studies with single administered doses of boldenone (17 beta-hydroxyandrosta-1,4-dien-3-one), 4-chloro-1,2-dehydro-17 alpha-methyltestosterone, fluoxymesterone, metandienone, 17 alpha-methyltestosterone, and [16,16,17-2H3] testosterone showed that 6 beta-hydroxylation is the major metabolic pathway in the metabolism of 4-chloro-1,2-dehydro-17 alpha-methyltestosterone, fluoxymesterone, and metandienone, whereas for boldenone, 17 alpha-methyltestosterone, and testosterone, 6 beta-hydroxylation is negligible.

PMID: 8539789 [PubMed - indexed for MEDLINE]
 
i use Xanax from time to time and i GUARANTEE that grapefruit juice enhances its effects. in fact, there's a warning on the prescription bottle regarding this. i wouldn't take it without it.
:)

Nadr
 
So why wouldn't you want to use grapefruit juice with your juice. You get more bang for your buck then right?

Scaggs
 
Grapefruit juice does NOT INCREASE ABSORBTION.


It reduces the ability for your body to metabolize certain drugs. In turn, the drug does not get broken down and it continues to circulate.


You can think of it as if the grapefruit juice is extending the halflife of the drug. It's very easy to accumulate TOO MUCH of a drug in your system in this way.


It has some application, but be careful and understand what you are doing. You are not simply increasing absorbtion.
 
I recommend starting with a low dose of Dbol like I plan on doing. Something along the lines of 20-25mgs ED just to get a feel.
 
Last edited:
Without knowing the rate at which grapefruit juice will limit the elimination of d-bol from your system, I wouldn't recomend making a practice of using the d-bol and grapefruit juice everyday.
 
I'm going to try it for the first week and evaluate my condition. If I'm suffering any adverse effects, I'll take the GFJ on weekdays only with the weekends off.
 
viagra?

Interesting how Viagra was on that list too. Guess I'll be switching from beer to vodka and grapefruit juice :D
 
Texas Ranger said:
I'm going to try it for the first week and evaluate my condition. If I'm suffering any adverse effects, I'll take the GFJ on weekdays only with the weekends off.
You might track your blood pressure and compare it to "normal" on cycle conditions. One week isn't very long, but with extended use I'd worry about severely reduced blood clotting, way too much red blood cell production, extremely negative blood lipid shifts, etc.

The 5 on 2 off might be a good idea.
 
bumping this cuz how much grapefruit juice is needed for some one who take 25-30 mg of DBOL?

12 oz? or 4 oz every time i pop d bol?
 
This works great i have used it many times..........
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to get an exact timing system set up, one would have to know at what % the halflife is slowed, then just do the math ........

but to get to the point here, doesn't this just end up being a money saver?

because at some point you would have to limit your intake anyways because of liver probs etc.........

so if you are now able to take say dbol and extend its release rate, you can now take more for the same $ or stay on longer for the same $......that's all i see this boiling down to......????
 
Anybody have any long-term experience with GFJ and D*Bol? tried with and without on DIFFERENT cycles, same dosage and noticed any difference?

Would this be recommended, or do you think that it would result in a toxic accumulation of the drug in your blood?

On the down side, GFJ has also been linked to higher estrogen levels:

http://news.bbc.co.uk/2/hi/health/6900482.stm
 
It would be more useful with expensive stuff like var (or primo acetate if its not a 17aa related phenomenon), and I recall a few threads or studies where it was talked about as being effective in that regard. I'll see if I can locate them.
 
Mavafanculo said:
It would be more useful with expensive stuff like var (or primo acetate if its not a 17aa related phenomenon), and I recall a few threads or studies where it was talked about as being effective in that regard. I'll see if I can locate them.

I'm not concerned about cost-savings, but more about health...I drink a cup of GFJ every morning...With a 4 week run of d*bol at 30mg/day, I'm wondering if this is going to increase the risk of nasty side effects because of a significant buildup of the d*bol in the blood?
 
hopefully me or someone else will be able to find the articles and threads which may answer that definitively, but my guess in the meantime would be that you would accummulate higher blood levels over time sure. if 30mg @ day is your upper limit of tolerence before sides, then you should titrate down. if you've experimented with various dose levels before you'll probably be able to tell where you're at approximately
 
Texas Ranger said:
Guys, I seen the studies that show Grapefruit juice increases the effectiveness of some oral drugs. Does anyone have any practical experience using the combo? I'm planning on drinking 4oz of Grapefruit juice several times throughout the day with each dose of Dbol(25mgs ED). Who has tried it and liked or disliked it???

Interesting. I'll have to read up on it.
 
trisorbagen is a new sup from ax designed to block liver enzymes ,it has the major ingredients of grapefruit and more and only 3 caps/day needed,check it out it looks good.
 
I don't know much about this tbh, but would be interested in finding out if it really works.

Does this apply to dbols only or other orals as well?
 
Just take dbol, var, etc immediatley following a meal. This is what is recomends on the pharm grade shit, because the food acts as a buffer and shuttles the compounds through your stomach and into your small intestine faster - which is where all the absorption takes place anyway. Post meal with half a cup of GFJ would probably be ideal.
 
Also , by simple logic, should the side affects with GFJ increase as well??

Because since it stays in the system longer and due to increased bioavaibility it looks like you are getting the same benefit like increasing dosage .

Any ideas????
 
I remember when I was in high school guys that did acid would drink juice with it. I searched a bit and found this info seems like it would pertain to oral AAS.


Fruit juice synergy

Several legends claim that drinking some specific type of fruit juice (varying from legend to legend) will intensify or shorten an LSD trip. While there is no specific physical evidence supporting this claim, if a person under the influence of LSD does something that they believe will intensify their trip, then they may feel a placebo effect. Note that grapefruit juice does interfere with the metabolism of some drugs; it has not been tested in conjunction with LSD.

It is, however, true that mixing an acidic juice such as lemon juice or orange juice may help extract certain alkaloids from natural sources as their more water soluble salts. This myth may be a mutated form of this technique.
 
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