D*n*p ??

[guards]

Your entitled to your opinion, but it still does not answer my question. And I am not trying to start a fight here but our opinions should be based on some logic with some supporting evidence. Otherwise we are no better than the anti-steroid groups that we bitch about all of the time. In fact, my arguing here is probably more centered around having people justify their claims. If we all did this, we would live in a much better world. Anyways, back to DNP.

When DNP is used in a fashion that is consistent with the DNP FAQ's protocol, where is the evidence showing that this has put anyone in danger?

And don't give me the, "I know somebody that". A few years ago when GHB was popular, I would run into so many people that knew a friend that had died from GHB.

The problem is that even the goverments own website showed only like 12 GHB related deaths over a 3 year period of time. So it was amazing how all of these people knew these 12 people.

I think GD mentioned that you could take 400mg of DNP and die. Show me the evidence that a single 400mg dose of DNP has killed anyone. I think the only way this would happen is if you were allergic. And I have admitted that this is one of the things that people need to be cautious about.

I can accept someone arguing that they are not comfortable with DNP because they don't know what the long term effects may be. But its hard for me to accept people saying that responsible use of DNP is dangerous when there is no evidence showing this. But yet we have a good amount of evidence that showed a large number of people using DNP over long periods of time and one of the only issues was a small number of women getting cataracts.

If you guys don't have prove that it is dangerous when then don't state so. If you don't feel comfortable with it and choose not to use it fine.

Alright, I am gonna take a stab at this.

You are probably correct that if you use DNP correctly it won't hurt you or anyone else. The problems rests with those that don't use DNP properly. I realise that you may have researched this drug to death, used it many times etc. The reason i am so anti-DNP is the ease in which someone can make a mistake. You are advocating the use of a, admit it, dangerous when abused/misused substance to the starter of this thread who is obviously NOT as knowledgeable as you on the subject of DNP. The relation of the ED50 to the LD50 of DNP is pretty damn close...too close for anyone to fuck up. How many times have you or I seen retards comin coming on this site asking if it is ok to drink on DNP? Or asking, AFTER THEY HAVE STARTED TO TAKE THE DAMN STUFF, how much insulin they should or should not be taking!!! COME ON DUDE! It's not the pro bodybuilder that i am worried about...it's the 17 year old fat kid who starts taking this shit thinking it's a diet pill. There is a big difference between a bodybuilder who has been monitoring their diet for the last ten years taking this type of drug and some half-wit student who has been working out "REALLY HARD" for the last 6 weeks and suddenly wants to have abs for spring break in daytona.


I'm sure DNP works great for those that have the knowledge and experience to back their drug regimens and diets. Those are not who i worry about. There is too much of a fine line for this drug to be fucked around with. If you miss a shot of test or take too much test what happens?? You A) become a bloated cow or B) crash (I know there is more to it than that but bear with me here). If you take too much DNP or intake the wrong things alongside it...what happens? You die. Can you overdose on deca, test, winny, fina??? Nope...not even if you tried. Some have tried, and failed, I am sure.



Moral of the story.......I am still anti-DNP.


Oh



and skittles are my secret to making me ONE SEXY ASS MOFO

 

[buckwheat1]

In my first post of this thread I relayed my current use and my experiences. My experiences have been favorable with few side effects. I also list the amounts that are used which are all reasonable amounts.

At the end of the post I did put the following info:

"There is a lot of good info and experiences about DNP on this board and others. You should take the time to read them and understand the pros and cons."

This was my attempt to get the starter of thread to reseach the topic further.

I could of added, "When DNP is not used properly serious side effects can occur, including death. You should research and understand the pros and cons of DNP before deciding to use it or not. "

 

[ceo]

I agree with Guards, I'm anti DNP also! Theres no evidence linking DNP to moderate use. but anything being used for insecticide is not going to be good for your body---You may not know it now but what about 10-20 yrs later!

RADAR

Like DDT. My dad tells me when he was in WWII in the south pacific that the planes would fly over and dump DDT on the islands...and the soldiers, locals, food, and everything else in the way.

What about asbestos? People used to walk through the stuff neck deep sometimes, with NO protection. Only relatively recently have they figured out that it causes cancer among other things.

Things like this may never be "discovered" about DNP because of the tiny percentage of people taking it. If 1/2 the population were using it though...who knows.

 

[halfaclue]

Your entitled to your opinion, but it still does not answer my question. And I am not trying to start a fight here but our opinions should be based on some logic with some supporting evidence. Otherwise we are no better than the anti-steroid groups that we bitch about all of the time. In fact, my arguing here is probably more centered around having people justify their claims. If we all did this, we would live in a much better world. Anyways, back to DNP.

When DNP is used in a fashion that is consistent with the DNP FAQ's protocol, where is the evidence showing that this has put anyone in danger?

And don't give me the, "I know somebody that". A few years ago when GHB was popular, I would run into so many people that knew a friend that had died from GHB.

The problem is that even the goverments own website showed only like 12 GHB related deaths over a 3 year period of time. So it was amazing how all of these people knew these 12 people.

I think GD mentioned that you could take 400mg of DNP and die. Show me the evidence that a single 400mg dose of DNP has killed anyone. I think the only way this would happen is if you were allergic. And I have admitted that this is one of the things that people need to be cautious about.

I can accept someone arguing that they are not comfortable with DNP because they don't know what the long term effects may be. But its hard for me to accept people saying that responsible use of DNP is dangerous when there is no evidence showing this. But yet we have a good amount of evidence that showed a large number of people using DNP over long periods of time and one of the only issues was a small number of women getting cataracts.

If you guys don't have prove that it is dangerous when then don't state so. If you don't feel comfortable with it and choose not to use it fine.

I have been preeching this same point for 2 years and it falls on def ears Bro. GD is a great bro who at least backs up his reasons. Some people here sound like the same folks that voted for banning ephadrine. "We don't know enough about it, and its not safe so ban it" I know many many people who use DNP...no deaths. We must be the lucky group since the death rate of DNP is so high.

 

[satchboogie]

its this kind of dnp thread that i like to see.
the facts plain and simple!

 

[halfaclue]

Just because a chemical is used for one purpose doesn't mean it can't have other therapeutic medical uses. For instance warfarin is widely used as a rat poison, but is also used as an anticoagulant in humans. Same chemical, same mechanism, big difference in dosage/body weight. Nitrolglycerin is best known as an explosive, but it's also used as a vasodilator for angina (heart pain).

Exaclty...Radar do you like salad dressing? Go home and drink a bottle of Vinegar and then let me know how you feel when you get out of the emergency room. Ever eat a twinkie? It shares ingriedents use to make fiberglass. Lots of things are used for dangerours or harmful reasons. Just because nitroglcerin is used for rocket fuel doesn't mean people with heart problems shouldn't breathe near an open flame. Not trying to flame ya or anything but I good tkae the time and find you 50 things that we (people) take everyday that are part of something else that is deadly.

 

[guards]

I have been preeching this same point for 2 years and it falls on def ears Bro. GD is a great bro who at least backs up his reasons. Some people here sound like the same folks that voted for banning ephadrine. "We don't know enough about it, and its not safe so ban it" I know many many people who use DNP...no deaths. We must be the lucky group since the death rate of DNP is so high.

I never said we don't know enough about the substance to be able to use it...I am saying that the majority of individuals using it don't know enough to be using it.

Crack is a great weight loss drug too. It'll speed up your metabolism and heart rate like a motherfucker and I am pretty sure that that majority of people who have used crack aren't dying on their first dose.


Now everybody is going to cry because i compared crack to DNP...come on guys, why is DNP so damn important? The gains vs sides aren't THAT spectacular.

 

[Fonz]

Compliments of macro:

DNP- Propaganda and the truth

--------------------------------------------------------------------------------

repost
MY COMMENTS IN ALL CAPS

What are dinitrophenols?
(Pronounced die ni'tro fe' nolz)
Dinitrophenols are a class of manufactured chemicals that do not occur naturally in the environment. There are six different dinitrophenols.
The most commercially important dinitrophenol, 2,4-dinitrophenol (DNP), is a yellow solid with no smell. It is used in making dyes, wood preservatives, explosives, insect control substances, and other chemicals, and as a photographic developer.
DNP DOES SMELL-VERY STRONG- KIND OF LIKE CHERRY WOOD
It was used in diet pills in the 1930s but was banned for this use in 1938. It may be sold under several trade names, including Caswell No. 392, Sulfo Black B, and Nitro Kleenup. Use of trade names is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry, the Public Health Service, or the U.S. Department of Health and Human Services.
What happens to dinitrophenols when they enter the environment?
DNP enters the air, water, and soil during its manufacture and use.
It may be formed from reaction of other chemicals in the air.
DNP may also enter the environment through landfill and storage tank leaks, or accidental spills during manufacture or transport.
It dissolves slightly in water, and does not easily evaporate to air.
It can be broken down slowly in water and soil by small organisms or by reacting with other chemicals.
DNP sticks to particles in water, which will cause it to eventually settle to the bottom sediment.
DNP also sticks to some types of soil particles, which may prevent it from moving very deep into the soil with rainwater.
DNP probably does not build up significantly in fish.
How might I be exposed to dinitrophenols?
Breathing contaminated workplace air where it is manufactured or used.
Breathing contaminated air from DNP-containing waste sites, waste incineration, or automobile exhaust.
Touching contaminated soil or water near DNP-containing waste sites.
Ingesting contaminated soil or water near DNP-containing waste sites.
DONT FORGET ENCAPUSLATING AND CONSUMING IT

How can dinitrophenols affect my health?
Most of the information on the health effects of dinitrophenols comes from old studies of patients who were prescribed diet pills containing dinitrophenol before it was banned.
Deaths have occurred in people who ingested 3-46 milligrams of dinitrophenols per kilogram of body weight per day (3-46 mg/kg/day) for short periods, or 1-4 mg/kg/day for long periods. WHILE THIS MAY BE TRUE THEY DIED FROM DEHYDRATION, HYPERTHERMIA, AND STARVATION/EXTREME LOW BLOOD SUGAR, ETC..- ALL OF WHICH CAN BE AVOIDED WITH PROPER NUTRITION, SUPPLEMENTS AND EATING- DONT FORGET THOSE CARBS. Also, people who breathed air containing 40 mg dinitrophenols per cubic meter of air (40 mg/m3) for long periods have died.
The amount of dinitrophenols ingested that causes harmful effects varies among people. Increased basal metabolic rate (the rate that you use energy at complete rest)- MAKES YOU LOSE FAT, increased sweating- DEHYDRATES YOU- WHY YOU TAKE GLYCEROL AND 2 GALLONS OF WATER MIN., a feeling of warmth, weight loss-WHY MOST PEOPLE TAKE IT, and increased heart rate-THIS IS NOT TRUE-EXCEPT IN CASES WHERE LOW BLOOD SUGAR RESULTS IN THE RELEASE OF GLUCAGON,ETC.., breathing rate-INCREASED RESPIRATION IS A NORMAL FUNCTION OF INCREASED METABOLISM, and body temperature have been observed in people who swallowed as little as 1 mg/kg/day or as much as 46 mg/kg/day for short or long periods of time.
Ingesting 2-4 mg/kg/day DNP for short or long periods has caused cataracts in some people-EIGHT CASES-THEY HAVE EIGHT ANECDOTAL CASES- WHICH REMARKABLY, WHEN COMPARED TO THE DNP INGESTING POPULATION (100,000 AT THE TIME), IS THE SAME AS AMONG THE GENERAL POPULATION-STILL WE TAKE EXTRA ANTIOXIDENTS- JUST IN CASE, while ingesting 1-4 mg/kg/day for short or long periods has caused skin rashes and decreases in white blood cells.-I HAVE SEEN NO RESEARCH THAT POINTS THIS OUT BUT SKIN RASHES WERE PROBABLY DUE TO LESS FATTY ACIDS FOR SKIN MAINTANANCE AND SOME ALLERGIC REACTIONS
How likely are dinitrophenols to cause cancer?
The Department of Health and Human Services (DHHS), the International Agency for Research on Cancer (IARC), and the EPA have not classified dinitrophenols for carcinogenicity. FOR GOOD REASON DNP HAS BEEN SHOWN TO NOT BE CARCINOGENIC
There are no studies available in people or animals on the carcinogenic effects of dinitrophenols.
WELL AREN'T WE LITTLE LIARS- THERE HAVE BEEN CANCER STUDIES IN ANIMALS 6 MONTHS AT HIGH EXPOSURE LEVELS IN MICE- NO CARCINOMAS
Is there a medical test to show whether I've been exposed to dinitrophenols?
Tests are available that measure the amount of DNPs or their breakdown products in blood, urine, and samples of tissue from the body. However, these tests may require special equipment and may not be available in your doctor's office.
Has the federal government made recommendations to protect human health?
The EPA recommends that not more than 70 parts of dinitrophenols per billion parts of water (70 ppb) be present in lakes or streams used for swimming.
The EPA lists DNPs as hazardous air pollutants (HAP) under the Clean Air Act. The EPA also requires that discharges or spills into the environment of 10 pounds or more be reported.
SOME EXTRA POINTS DNP IS ANTI PROTEOLYTIC- MUSCLE SPARING-
DNP IS STILL DANGEROUS IF TAKEN INCORRECTLY AND/OR WITHOUT THE PROPER PREPARATIONS. ITS USE IS NOT AN UNDERTAKING THAT SHOULD BE ENTERED INTO WITHOUT CONSIDERABLE KNOWLEDGE AND RESEARCH- KNOWLEDGE IS POWER.
heres a short list of supplements
feel free to add any other antioxidents
200mg alpha lipoic acid 3x a day with meals
1200-1500mg magnesium in 2-3 divided doses.
2-3000mg vitamin C.
1200IU of vitamin E
200mcg of selenium.
1000-2000mg of calcium (can’t take it with the magnesium, though. Take it before bed)
Melatonin if you can’t sleep and it is also one of the best and cheapest anti-oxidants.
50mg of zinc a day
one iron tab as hemoglobin is a protein as well.
A potassium gluconate tab or two a day
Taurine at 3g a day.
Glutamine at 15g-20g a day .
1 table spoon glycerol 3 x a day
at least 2 gallons of water
a fan to point at your head while sleeping- or at work- basically anytime you can point a fan at you
personally I take a lot of supplements
i usually exceed those dosages and I take other antioxidents
including about
500mg grapeseed extract
300mg cranberry extract
600-900mg of green tea
and a good mulit vitamin-twinlab dualtabs
BTW- EC+1g of tyrosine 3x per day and 20mg of yohimbine topically 2x per day- for added energy and fatburning effects
DNP WHY IS THE LD-50 SO LOW
all of the mortality studies that have been done with dnp have been done on animals. LD50 is the dose that is considered to be lethal to 50% of the population. However, when one looks at the studies and the inferences that people, including duchaine, have made, you will find that such inferences are completely erroneous. They have based their dosing and life threatening parameters of DNP ingestion on studies done on organisms incapable of changing their behaviour to cope with the effects of DNP.
Here is some of the reasons why.
can you tell a rat he needs to triple or quadruple his water consumption?
even if the water is available will a rat force himself to drink it? like a human could
do rats take glycerol?
do they take antioxidents?
do they have fans to point at their heads?
can they lower the dosage if they feel its too strong for them?
can they turn up the AC?
can you see some of the fallacies of such studies-if not I will be sure to continue.


PEACE

 

[Fonz]

Courtesy of Macro and Fonz:

The 7-day DNP fat loss inferno cycle:

The 7-day DNP fat loss inferno cycle involves a moderate to high dosage of DNP for fat burning. The DNP fat loss inferno involves a 7-day on, 7-day off approach with four distinct phases. Most athletes using DNP follow this type of cycle. The phases are as follows:

Phase 1: The 3-day Carb-Depletion Phase.
Phase 2: The 1-day Thyroxine (T3) Re-normalization Phase.
Phase 3: The 14-day DNP Inferno Phase.
Phase 4: The 2-day Post-DNP Phase.

Phase 1. The 3-day Carb-depletion phase
Phase One has a three-day duration and begins the four days preceding the ingestion of DNP. The purpose of this phase is to deplete muscle-glycogen content by restricting carbohydrates. This is achieved through a Ketogenic style diet.

Kcals should be restricted to 10-12 times bodyweight in lbs. And carbohydrates should be restricted to less than 60g/day. Protein is consumed at 1 gram per pound of bodyweight or higher and the remaining dietary calories should come from fat.

This phase lasts exactly 3 days, and will reduce muscle-glycogen levels so that the body is forced to rely on fat as fuel more readily when you start your DNP cycle.

Phase 2 The 1-day Thyroxine (T3) Re-normalization Phase
This is a new concept for DNP dieting. During the past three days, the athlete has restricted carbohydrates and as a direct consequence T4-T3 conversion is slowed down resulting in reduced T3 levels. This is bad for the DNP phase, as you need enough active T3 to last throughout the entire 7-day on DNP phase.

Day four of the DNP cycle involves a mega-carbohydrate meal at mid-afternoon (4-6PM) designed to create a massive insulin spike and re-normalize T4-T3. This concept has been extrapolated from ketogenic diets and has been shown to dramatically increase serum concentrations of T3.

Day 4 involves Keto eating until the Mega-carb meal. Then in the late afternoon, at least circa 250g of carbohydrates must be consumed to create an insulin spike. Any sugar (fructose, sucrose, maltose etc.) is fair game. Fructose in particular is good because it primarily re-fills liver glycogen which is directly involved in T4-T3 conversion. (Empty liver glycogen signals the thyroid to decrease T4-T3 conversion).

As a side-note, a 250g carb-meal after three days of Keto dieting creates a more pronounced insulin spike than would a 250g carb-meal after three days of normal eating.

Kcals during Phase 2 should be kept at 15X Bodyweight in lbs. Macro-nutrient break-downs can be calculated by the athlete. The only carb intake on day 4 should be the 250g carb-meal.

Phase 3 The 14-Day DNP Phase

The first two days of actual DNP consumption are the most important to follow correctly. During Days 1 and 2 of the actual DNP portion of the cycle, it must be determined if the athlete will have an allergic reaction to DNP.

Day 1: 200 mg of DNP is ingested
Day 2: 200 mg of DNP is ingested

At this point the dieter should be able to assess if an allergic reaction has occurred. A DNP-stimulated allergic reaction will lead to swelling in as little as 1 to 2 days time. Approximately 10% of athletes will have such a reaction. The unfortunate few who experience this type of a reaction must terminate the cycle immediately. Benadryl or Ketotifen (Anti-histamines) can be used to treat mild symptoms. Obviously a doctor should be consulted should the symptoms prove more severe.

Day 3: Dieters making it to day 3 of the DNP phase have the option of increasing their dosage. The normal dosage for beginners is 400mg DNP/day. Even an amount this small should provide outstanding results. A word of caution. DO NOT TAKE MORE, if you are not experienced with DNP-use. More advanced users may chose to go higher based on past experience.
The 400mg/day dosage is maintained from Day 3 through Day 9(Exactly 7 days). The last dose is taken on Day 9.

Supplementation and Nutritional Protocol for a DNP cycle:

1. An ECA stack is beneficial while on a DNP cycle as it as it acts as an anorectant. DNP raises Neuro-peptide Y levels in the brain, which is directly linked to increased hunger. Consuming 75-100mg total of ephedrine alkaloids/day should be sufficient to suppress appetite. PPA (Nor-ephedrine) should NOT be used as it causes lethargy when combined with DNP.

2. Anti-oxidants. Due to the DNP induced rapid combustion of fats, free-radical production skyrockets up-wards. To combat this, anti-oxidants must be used. Anti-oxidants are the single most important supplement to take on a DNP cycle.

a) Fat-soluble Anti-O: Vitamin E: 1000mgs/day
b) Water-soluble Anti-O: Vitamin C: 2-3g/day
c) Alpha Lipoic acid: 600-1000mgs/day

Dual-anti-oxidant: BOTH fat & water-soluble actually re-cycles other anti-oxidants.

3. Glycerol: Although optional, glycerol is often consumed at 15ml's 3X/day. Glycerol increases hydration for many athletes.
No additional supplements are really required other than these three. All the rest you have read in various DNP articles are more for peace of mind than improved functionality. I consider them overkill.

4. Water: Not a supplement, but an absolute necessity.
DNP causes sweating and can be incredibly dehydrating. Dehydration is the NUMBER ONE cause of most DNP problems and deaths. Excessive dehydration results in over-heating. Dieters who do not replenish fluids properly while on a DNP cycle could die. The consensus among athletes is that at least two gallons of water must be consumed daily.

5. EAT FRUIT while on your DNP cycle.

Fruit for some reason has been found to greatly reduce the lethargy associated with a DNP cycle. It also has a high water content, therefore it helps to keep the dieter hydrated. Watermelon is an obvious recommendation.

6. Dietary intake: There are several schools of thought on this matter, but sticking to the old standard always works.
Kcals should be kept anywhere from 10-15X Bodyweight in lbs. Macro-nutrient break-downs should be kept at around 20% fat, 30% protein and 50% carbs. (Changing the ratios in favor of more carbs and protein w/ less fat will result in a more fat loss but nothing special. Also, remember that more carbohydrates means more heat.)

Take for example the 220 lb (100 kg) bodybuilder. He would consume anywhere from 2200 to 3300Kcal /day (Depending on his appetite control).

WHAT NOT TO DO on a DNP cycle.

a) Do not under any circumstances consume alcohol or ANY type of diuretic while on a DNP cycle. Alcohol and diuretics will dehydrate you and can cause SERIOUS problems.
b) Do not remain in a hot environment without replenishing fluid loss due to perspiration. This too can also cause SERIOUS problems.
c) Do not begin with a high dosage of DNP if you are a novice. This is just asking for a trip to the ICU.

The half-life of 2,4 Dinitrophenol is 36 hours. So, after 36 hours, there is only 50% of the DNP remaining in your system. Therefore, 72 hours later 25% remains. Then 12.5% remains after 108 hours. After 5 days (120 hours), there's roughly 9% of the DNP left in your body that you had on Day 9. This DNP concentration is low-enough to allow you to begin Phase 4 of the cycle -- the 2-day Post-DNP phase -- without compromising glycogen synthesis rates. Kcals during Days 10-14 should remain the same as during days 3-9.

Phase 4: The 2 day Post DNP Phase.

The whole purpose of this phase is to get muscle-glycogen levels back to normal. The Ketogenic carb-up can be used as a sort of template for this phase.

After Phases two and three, muscle-glycogen levels are depressed and need to be replenished.

Day 15: Carb-intake should be 7g/Kg of LBM (lean body mass = bodyweight minus body fat.) So assuming a 220 lb bodybuilder has 0% body fat, lol, he would consume 700 g of Carbs. Protein-intake remains at 1g/lb and fat is restricted as low as possible.
The focus on day 1 should be on High-GI foods like Fat-free Ice-cream and all the other non-fat high sugar desserts. Calories should be around 4000 for the 220-lb bodybuilder -- in other words, 18X bodyweight in lbs.

Drastically restricting fat is CRITICAL here, as the body is still burning fat for fuel as you replenish your glycogen stores. In essence, the dieter is still losing fat while carbing up.

Day 16: Muscle-glycogen has increased, so carb-intake should be decreased from day one’s 7g/Kg to only 5g/Kg of LBM. That would be 500g for our 220-lb bodybuilder. Protein is 1g/lb again. Fat remains as low as possible. Kcals for the dieter are reduced to 3000 Kcal range, or around 14X Bodyweight in lbs. The focus of Day 2 should be low-GI foods like vegetables, milk, lean meats etc.

Additional Precautions:

Dieters feeling extremely nauseated or who vomit during a cycle should discontinue use immediately and not restart for at least 36 hours.

Dieters should carry a pocket thermometer at all times. If body temperature rises above 102 Fahrenheit then the dosage should be lowered or the cycles should be terminated. Additionally, the dieter should take a very cold bath to lower the temperature.
In addition to water, V8 juice should be consumed. Drinking gallons of water depletes the body of electrolytes pretty badly predisposing the dieter to shock, nausea, lethargy, and even death. V8 is the best for replenishing electrolytes as it contains 950mg of potassium per 8oz compared to Gatorade’s 35mg of potassium in 8oz.

Massive amounts of fruits and sweets should be consumed if one becomes nauseated or vomits – i.e. force feed yourself.
Dieters should never allow themselves to become overheated on a DNP cycle. Always stay next to a fan and keep the air conditioner on. Do not attempt a DNP cycle if you work out doors in a warm climate or another warm environment like a kitchen. Even at low doses this can build up and be potentially dangerous.

There are two versions of DNP – regular and crystalline. Know which one you are taking. When taking the crystalline DNP caps, never take more than 200mg at once if you've never used it before. Even if you are used to it, it is still much safer to spread the dosage throughout the day. Crystalline DNP is much faster acting and can rapidly elevate temperature.

Post-Steroid Cycle Use of DNP

One of the primary causes of muscle breakdown after a steroid cycle is suppressed TSH. Anabolic steroids suppress TSH, which in turn lowers T3 and T4 production by the thyroid gland. The reduction in TSH is one reason that anabolic steroids are such excellent muscle builders.

Soon after the completion of a steroid cycle, TSH up-regulates, which in turn super-stimulates the thyroid. This excess stimulation causes the thyroid to produce above normal levels of T3 and T4. This increase in thyroid hormones is highly catabolic and is the main reason why people lose muscle post-cycle.

Athletes have learned that they need to restrict T3 production post cycle to prevent muscle loss. A novel approach to achieving this goal is the use of DNP. About 80% of the body’s endogenous T3 is produced from the metabolically inactive T4 to the metabolically active T3. The de-iodinase enzyme is responsible for this conversion. It literally cleaves off an iodine molecule.
By ingesting 200mg DNP/day, the athlete can correct the over stimulated Thyroid, returning T3 levels back to normal. DNP directly blocks the production of T3 from T4 via the de-iodinase enzyme.

As a bonus, the reduction in your ATP stores because of the DNP is counter acted by an increase in the oxidation of triglycerides as an energy source. The benefit is the elimination of any potential fat-gain from the low post-cycle testosterone levels. And as DNP is non-hormonal, it has no effect on HPTA recovery.

After cessation of DNP use post-cycle, the athlete will reap the benefits of the "Anabolic Rebound Effect" which further lends credence to the use of DNP as a post-cycle ancillary for the elimination of any post-cycle muscular losses.

Macro’s DNP Supplements

200mg alpha lipoic acid 3x a day with meals
1200-1500mg magnesium in 2-3 divided doses.
2-3000mg vitamin C
1200IU of vitamin E
200mcg of selenium.
1000-2000mg of calcium (can’t take it with the magnesium, though. Take it before bed)
Melatonin if you can’t sleep and it is also one of the best and cheapest anti-oxidants.
50mg of zinc a day
one iron tab as hemoglobin is a protein as well.
A potassium gluconate tab or two a day
Taurine at 3g a day.
Glutamine at 15g-20g a day .
1 table spoon glycerol 3 x a day
at least 2 gallons of water
a fan to point at your head while sleeping- or at work- basically anytime you can point a fan at you
500mg grapeseed extract
300mg cranberry extract
600-900mg of green tea
a good mulit vitamin
EC+1g of tyrosine 3x per day and 20mg of yohimbine topically 2x per day- for added energy and fat burning effects

 

[Fonz]

Courtesy of another great researcher...SmokingHawk:

Is DNP safe?

--------------------------------------------------------------------------------

Here's my research. This is AMAZING! Not only has not a single test found it to be carcinogenic, but test after tyest after test find that DNP actually ATTACKS cancer cells, and helps anti-cancer medications work better, and helps anti-leukemia medications work without destroying cell DNA, and suppresses tumor growth by 20-50%. The summaries are all right here, friends. Karma me up!

DNP is Ames negative, and does not promote tumors. See for yourself at http://toxnet.nlm.nih.gov/

http://www.epa.gov/ttn/atw/hlthef/dinitrop.html reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.

http://www.cyberiron.com/drugs/dinitrophenol.html reports on halth risks from external exposue. In other words, don’t get it in your eyes, or on your skin if you’re allergic. Pretty elementary stuff.

http://www.ebec2000.com/abstracts/056.htm This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.

http://www.zymed.com/pdf/04-xxxx/04-8300.pdf A PDF file about an antidote to DNP.

http://www.boehringer-ingelheim.es/...glesa/cap13.htm finds that DNP did not activate liver enzymes (MAT) associated with liver damage

"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.

"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know—it’s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst results being softened stools and gas).

"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as…2,4-dinitrophenol (DNP)."

"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out—DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure…"


"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.

Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it’s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer…fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP can be synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.

"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it’s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity…"

"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP’s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.

"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.

"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates—or disrupts—cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.

"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT (good ol’ DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect…"

"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide by neutering themselves. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."

"Autocatabolism of surface macromolecules shed by human melanoma cells." Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps melanoma cells die (autocatabolize) while other cells are unaffected.

http://www.geocities.com/byggdegstor/dnpforside - tons of research, including medical studies. Excerpts:

DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation © 1996 Robert Ames)

Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."

"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."

"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."

"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."

"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."

"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."


Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.
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