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Creatine Study?
- Thread starter HvyW8
- Start date
B
Big Jroy
Guest
I've been looking for years bro and have yet to find any concrete proof it's bad for you.
L
lartinos
Guest
A baseball player (derek bell) blamed his sudden kidney problem on it a few years back when it was really popular. I wonder if alonzo mourning was taking any creatine. He was fuckin jakt before his kidneys blew.
under_dawg
New member
The only studies to ever show negative effects of creatine on the kidneys were a few studies done on patients who had already suffered from renal diseases. THe media got a hold of these studies and well....you know what happens then. I remember the Derek Bell case and i believe he was also taking upwards of 10 times the average daily doses of creatine....check out Pubmed. Great source.
UD
UD
under_dawg
New member
For Example:
Curr Sports Med Rep. 2002 Apr;1(2):103-6. Related Articles, Links
Effects of creatine use on the athlete's kidney.
Farquhar WB, Zambraski EJ.
HRCA Research and Training Institute, Harvard Division on Aging, 1200 Centre Street, Boston, MA 02131, USA. [email protected]
With regard to athletes attempting to improve their performance, at the present time creatine monohydrate is clearly the most widely used dietary supplement or ergogenic aid. Loading doses as high as 20 g/d are typical among athletes. The majority (> 90%) of the creatine ingested is removed from the plasma by the kidney and excreted in the urine. Despite relatively few isolated reports of renal dysfunction in persons taking creatine, the studies completed to date suggest that in normal healthy individuals the kidneys are able to excrete creatine, and its end product creatinine, in a manner that does not adversely alter renal function. This situation would be predicted to be different in persons with impaired glomerular filtration or inherent renal disease. The question of whether long-term creatine supplementation (ie, months to years) has any deleterious affects on renal structure or function can not be answered at this time. The limited number of studies that have addressed the issue of the chronic use of creatine have not seen remarkable changes in renal function. However, physicians should be aware that the safety of long-term creatine supplementation, in regard to the effects on the kidneys, cannot be guaranteed. More information is needed on possible changes in blood pressure, protein/albumin excretion, and glomerular filtration in athletes who are habitual users of this compound.
Publication Types:
Review
Review, Tutorial
PMID: 12831718 [PubMed - indexed for MEDLINE]
Curr Sports Med Rep. 2002 Apr;1(2):103-6. Related Articles, Links
Effects of creatine use on the athlete's kidney.
Farquhar WB, Zambraski EJ.
HRCA Research and Training Institute, Harvard Division on Aging, 1200 Centre Street, Boston, MA 02131, USA. [email protected]
With regard to athletes attempting to improve their performance, at the present time creatine monohydrate is clearly the most widely used dietary supplement or ergogenic aid. Loading doses as high as 20 g/d are typical among athletes. The majority (> 90%) of the creatine ingested is removed from the plasma by the kidney and excreted in the urine. Despite relatively few isolated reports of renal dysfunction in persons taking creatine, the studies completed to date suggest that in normal healthy individuals the kidneys are able to excrete creatine, and its end product creatinine, in a manner that does not adversely alter renal function. This situation would be predicted to be different in persons with impaired glomerular filtration or inherent renal disease. The question of whether long-term creatine supplementation (ie, months to years) has any deleterious affects on renal structure or function can not be answered at this time. The limited number of studies that have addressed the issue of the chronic use of creatine have not seen remarkable changes in renal function. However, physicians should be aware that the safety of long-term creatine supplementation, in regard to the effects on the kidneys, cannot be guaranteed. More information is needed on possible changes in blood pressure, protein/albumin excretion, and glomerular filtration in athletes who are habitual users of this compound.
Publication Types:
Review
Review, Tutorial
PMID: 12831718 [PubMed - indexed for MEDLINE]
under_dawg
New member
ANother,
: Med Sci Sports Exerc. 1999 Aug;31(8):1108-10. Related Articles, Links
Comment in:
Med Sci Sports Exerc. 2000 Jan;32(1):248-9.
Long-term oral creatine supplementation does not impair renal function in healthy athletes.
Poortmans JR, Francaux M.
Chimie Physiologique, Institut Superieur d'Education Physique et de Kinesitherapie, Universite Libre de Bruxelles, Brussels, Belgium. [email protected]
PURPOSE: Oral creatine supplementation is widely used in sportsmen and women. Side effects have been postulated, but no thorough investigations have been conducted to support these assertions. It is important to know whether long-term oral creatine supplementation has any detrimental effects on kidney function in healthy population. METHODS: Creatinine, urea, and plasma albumin clearances have been determined in oral creatine consumers (10 months to 5 yr) and in a control group. RESULTS: There were no statistical differences between the control group and the creatine consumer group for plasma contents and urine excretion rates for creatinine, urea, and albumin. Clearance of these compounds did not differ between the two groups. Thus, glomerular filtration rate, tubular reabsorption, and glomerular membrane permeability were normal in both groups. CONCLUSIONS: Neither short-term, medium-term, nor long-term oral creatine supplements induce detrimental effects on the kidney of healthy individuals.
Publication Types:
Clinical Trial
PMID: 10449011 [PubMed - indexed for MEDLINE]
: Med Sci Sports Exerc. 1999 Aug;31(8):1108-10. Related Articles, Links
Comment in:
Med Sci Sports Exerc. 2000 Jan;32(1):248-9.
Long-term oral creatine supplementation does not impair renal function in healthy athletes.
Poortmans JR, Francaux M.
Chimie Physiologique, Institut Superieur d'Education Physique et de Kinesitherapie, Universite Libre de Bruxelles, Brussels, Belgium. [email protected]
PURPOSE: Oral creatine supplementation is widely used in sportsmen and women. Side effects have been postulated, but no thorough investigations have been conducted to support these assertions. It is important to know whether long-term oral creatine supplementation has any detrimental effects on kidney function in healthy population. METHODS: Creatinine, urea, and plasma albumin clearances have been determined in oral creatine consumers (10 months to 5 yr) and in a control group. RESULTS: There were no statistical differences between the control group and the creatine consumer group for plasma contents and urine excretion rates for creatinine, urea, and albumin. Clearance of these compounds did not differ between the two groups. Thus, glomerular filtration rate, tubular reabsorption, and glomerular membrane permeability were normal in both groups. CONCLUSIONS: Neither short-term, medium-term, nor long-term oral creatine supplements induce detrimental effects on the kidney of healthy individuals.
Publication Types:
Clinical Trial
PMID: 10449011 [PubMed - indexed for MEDLINE]
under_dawg
New member
Sports Med. 2000 Sep;30(3):155-70. Related Articles, Links
Adverse effects of creatine supplementation: fact or fiction?
Poortmans JR, Francaux M.
Physiological Chemistry, Higher Institute of Physical Education and Readaptation, Free University of Brussels, Bruxelles, Belgium. [email protected]
The consumption of oral creatine monohydrate has become increasingly common among professional and amateur athletes. Despite numerous publications on the ergogenic effects of this naturally occurring substance, there is little information on the possible adverse effects of this supplement. The objectives of this review are to identify the scientific facts and contrast them with reports in the news media, which have repeatedly emphasised the health risks of creatine supplementation and do not hesitate to draw broad conclusions from individual case reports. Exogenous creatine supplements are often consumed by athletes in amounts of up to 20 g/day for a few days, followed by 1 to 10 g/day for weeks, months and even years. Usually, consumers do not report any adverse effects, but body mass increases. There are few reports that creatine supplementation has protective effects in heart, muscle and neurological diseases. Gastrointestinal disturbances and muscle cramps have been reported occasionally in healthy individuals, but the effects are anecdotal. Liver and kidney dysfunction have also been suggested on the basis of small changes in markers of organ function and of occasional case reports, but well controlled studies on the adverse effects of exogenous creatine supplementation are almost nonexistent. We have investigated liver changes during medium term (4 weeks) creatine supplementation in young athletes. None showed any evidence of dysfunction on the basis of serum enzymes and urea production. Short term (5 days), medium term (9 weeks) and long term (up to 5 years) oral creatine supplementation has been studied in small cohorts of athletes whose kidney function was monitored by clearance methods and urine protein excretion rate. We did not find any adverse effects on renal function. The present review is not intended to reach conclusions on the effect of creatine supplementation on sport performance, but we believe that there is no evidence for deleterious effects in healthy individuals. Nevertheless, idiosyncratic effects may occur when large amounts of an exogenous substance containing an amino group are consumed, with the consequent increased load on the liver and kidneys. Regular monitoring is compulsory to avoid any abnormal reactions during oral creatine supplementation.
Publication Types:
Review
Review, Tutorial
PMID: 10999421 [PubMed - indexed for MEDLINE]
Adverse effects of creatine supplementation: fact or fiction?
Poortmans JR, Francaux M.
Physiological Chemistry, Higher Institute of Physical Education and Readaptation, Free University of Brussels, Bruxelles, Belgium. [email protected]
The consumption of oral creatine monohydrate has become increasingly common among professional and amateur athletes. Despite numerous publications on the ergogenic effects of this naturally occurring substance, there is little information on the possible adverse effects of this supplement. The objectives of this review are to identify the scientific facts and contrast them with reports in the news media, which have repeatedly emphasised the health risks of creatine supplementation and do not hesitate to draw broad conclusions from individual case reports. Exogenous creatine supplements are often consumed by athletes in amounts of up to 20 g/day for a few days, followed by 1 to 10 g/day for weeks, months and even years. Usually, consumers do not report any adverse effects, but body mass increases. There are few reports that creatine supplementation has protective effects in heart, muscle and neurological diseases. Gastrointestinal disturbances and muscle cramps have been reported occasionally in healthy individuals, but the effects are anecdotal. Liver and kidney dysfunction have also been suggested on the basis of small changes in markers of organ function and of occasional case reports, but well controlled studies on the adverse effects of exogenous creatine supplementation are almost nonexistent. We have investigated liver changes during medium term (4 weeks) creatine supplementation in young athletes. None showed any evidence of dysfunction on the basis of serum enzymes and urea production. Short term (5 days), medium term (9 weeks) and long term (up to 5 years) oral creatine supplementation has been studied in small cohorts of athletes whose kidney function was monitored by clearance methods and urine protein excretion rate. We did not find any adverse effects on renal function. The present review is not intended to reach conclusions on the effect of creatine supplementation on sport performance, but we believe that there is no evidence for deleterious effects in healthy individuals. Nevertheless, idiosyncratic effects may occur when large amounts of an exogenous substance containing an amino group are consumed, with the consequent increased load on the liver and kidneys. Regular monitoring is compulsory to avoid any abnormal reactions during oral creatine supplementation.
Publication Types:
Review
Review, Tutorial
PMID: 10999421 [PubMed - indexed for MEDLINE]
under_dawg
New member
http://www.ncbi.nlm.nih.gov/entrez/...=Display&dopt=pubmed_pubmed&from_uid=12831718
this way is probably easier...just read you lazy bastards!
J/k!
i keed i keed....
UD
i dont' know...i'm feeling crazy today.
this way is probably easier...just read you lazy bastards!
J/k!i keed i keed....
UD
i dont' know...i'm feeling crazy today.
