Chronic Pot Smoking slows recovery

[twistedneck]

Chronic is getting stoned 3x / week or more.

[Review and update: marijuana and reproduction]

[Article in Spanish]

Pardo G, Legua V, Remohi J, Bonilla-musoles F.

PIP: Longterm use of marijuana has been found to cause physiological changes that can alter individual reproductive potential. The effects of marijuana depend on the dose and can include death from depression of the respiratory system. Longterm effects are however particularly hard to assess. Marijuana is absorbed rapidly and eliminated very slowly. The active principle, delta-9-tetrahidrocannabinol (delta-9-THC), is highly liposoluble and fixes to the serum proteins, passing to the lungs and liver for metabolization and to the kidneys and liver for excretion. As with estrogens, there is an enterohepatic circuit for reabsorption and elimination. 90% is eliminated in the feces, 65% within 48 hours. Because of the enterohepatic circuit and liposolubility, elimination requires 1 week for completion. The other important biotransformation of the active principle is hydroxilation; the hydroxilated derivatives are responsible for the psychoactivity of cannabis. Cannabis affects both neuroendocrine function and the germ cells. Studies on experimental animals have indicated that THC can cause a decline in the pituitary hormones follicle stimulating hormone, luteinizing hormone, and prolactin, and in the steroids progesterone, estrogen, and androgens. Human studies have shown that chronic users have decreased levels of serum testosterone. Because steroidogenesis can be restimulated with human chorionic gonadotropin, it appears that THC does not directly affect steroid production by the corpus luteum, but that its action is mediated by the hypothalamus. Because of its potent antigonadotropic action, THC is under study as an anovulatory agent. The same animal studies have shown that ovulation returns to normal 6 months after termination of use. High rates of anovulation and luteal insufficiency have been observed in women smoking marijuana at least 3 times weekly. THC accumulates in the milk. Animal studies have shown that THC depresses the enzymes necessary for lactation and causes a diminution in the volume of the mammary glands. In recent studies, significant amounts of the drug have been detected in both mothers' milk and the blood of newborns. Animal studies indicate that THC crosses the placenta, achieving concentrations in the fetus as high as those in the mother. Animal studies also demonstrated increasing frequency of abortions, intrauterine death, and declines in fetal weight. The effects were probably due to an alteration in placental function. A human study likewise showed that marijuana use during pregnancy was significantly related to poor fetal development, low birth weight, diminished size, and decreased cephalic circumference. Congenital malformations have been observed in experimental animals exposed to THC. Declines in sperm volume and count and abnormal sperm motility have been observed in chronic marijuana users. In vitro studies show that THC produces a marked degeneration of human sperm.

 

[Doktor Bollix]

I really don't care but I thought this might be interesting. I stopped reading when I reached "The effects of marijuana ..can include death."

Lost credibility at this point IMO.

 

[anabolicmd]

Anything over 30 bong hits a day tends to slow down recovery for me, but not much. I just take an extra day off, and it evens out.

 

[gilly6993]

I guess I'm chronic....

 

[twistedneck]

I'm a former 30+ BH / day too.. i've cut back to 3x / week 1 BH. I'm wondering if its still too much. I want to max out my natural T.

 

[twistedneck]

Rat study

Effects of delta 9-tetrahydrocannabinol on copulatory behavior and neuroendocrine responses of male rats to female conspecifics.

Murphy LL, Gher J, Steger RW, Bartke A.

Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901.

Male rats exposed to sexually receptive females, exhibit a rapid increase in plasma levels of luteinizing hormone (LH) and prolactin, and concomitant increases in noradrenergic activity in the medial basal hypothalamus (MBH) and median eminence (ME) as well as in dopaminergic activity in the MBH. Delta-9-tetrahydrocannabinol (THC; 5 mg/kg b.wt., PO), the chief psychoactive constituent of marijuana, blocked the MBH and ME noradrenergic response and the dopaminergic response in the MBH in male rats exposed for 20 min to sexually receptive females, and suppressed the expected increases in plasma LH and prolactin levels. Moreover, THC treatment decreased the percentage of animals exhibiting copulatory behavior and increased the latency periods to mount and intromit. These findings indicate that THC interferes with the neuroendocrine and behavioral responses of male rats to the presence of a receptive female.

But then I pulled this study that showed little if any effect!! whats up here.

Serum testosterone concentrations in cannabis and opiate users

Article in German

Friedrich G, Nepita W, Andre T.

Institut fur Rechtsmedizin, Universitat Freiburg.

The object of this study was to establish possible influences of long-term cannabis usage on plasma testosterone levels. The plasma testosterone levels of 66 male Pakistani who for years had smoked cannabis daily or drank cannabis regularly where measured after chronic and acute intake of the drug and compared with a material of 41 normal controls, i.e. persons who did not use cannabis. An evaluation of the results showed that there were no significant differences between the two groups. No influence of long-term cannabis usage on plasma testosterone levels was found. Furthermore we wished to find out wether long-term heroin abuse showed an effect on plasma testosterone levels. The concentrations of testosterone in the plasma of 102 heroin addicts assigned to a Methadone Program were measured and compared with the values of 29 male healthy students as controls. Plasma testosterone levels were found to be significantly decreased in heroin addicts as compared to controls.

 

[chewyxrage]

"The effects of marijuana depend on the dose and can include death from depression of the respiratory system."



LMAO

Yeah if you hook yourself up to a bong respirator and pass out with it on for 3 days.....

Hey, it's 4:20.....

 

[punchbagforyou]

Joke

 

[blazin121]

uh oh!

this reminds me of a article that pot contains female hormones

damn science nerds dont have any attentions so they start making up stories... sad

 

[Judo Tom]

i notice that the less i smoke the faster i recover.. but this could have very little to do with the smoke and more to do with the laziness that can set in.. especially post cycle i am in general more prone to be lazy/depressed/not motivated.. and pot doesnt help with any of them

i normally dont smoke at all the first week of pct and just try to get myself in recovery mode which for me is decreased training time increase calories sleep more and increase fat intake