Hi Unclep
Below are some info I've found about b12 injections which might be of interest and that might answer some of your questions:
Vitamin B12 Injections (Hydroxocobalamin)
Vitamin B12 injections have been used for a long time in the treatment of various problems in medicine, especially related to chronic fatigue states. However, in the past, there were few well-controlled trials looking at the efficacy of vitamin B12 injections, especially in the company of normal serum vitamin B12 levels. More recently, the use of vitamin B12 injections has been subjected to good clinical trials and shown to be very efficacious.
In general, what one might expect from vitamin B12 is an improved sense of well being, a lifting of depression and improved sleep patterns. Many people report very colorful dreams. Fatigue is generally improved. People feel motivated to undertake many activities that they would not previously have been able to tolerate. The usual route of administration is injection into the muscle (or IM).
Although many people notice an effect rather immediately after one injection, some patients will not notice an effect until a cumulative threshold has been reached, after twice weekly injections for a period of five to six weeks. The dose may also need to be adjusted. Sometimes, a dose of 1,000 mcg per injection is adequate. In other cases, doses as high as 5,000 mcg are required. These preparations generally need to be manufactured by a compounding pharmacy with the appropriate facilities to prepare sterile injections.
The form of vitamin B12 that we prefer to use at the Center is hydroxocobalamin. Standard prescription availability at general pharmacies is cyanocobalamin injection. There are those in the field of nutritional medicine that have expressed some discomfort with injecting a cyanide-based vitamin B12 derivative. For that reason, the compounding pharmacies, such as Nora Apothecary (in Indianapolis) and Hopewell Pharmacy (in New Jersey) have made available a more user-friendly form of vitamin B12 injection, called hydroxocobalamin. It is the version preferred by the Center, and I have noted it to be very efficacious.
In general, side effects are low. There is no known toxicity from vitamin B12 overdose. Occasionally, some people may notice discomfort at the site of injection or a mild erythematous rash. You should advise the nurse of that reaction, if it occurs. On rare occasions, it causes some agitation and feelings of "hyperness," similar to those experienced after drinking a caffeinated beverage. If that occurs, the dose should be reduced or the therapy may need to be discontinued.
peace
