I always massage the site for about 5min after a shot and that seems to help. I dont use QV anymore because it seems to hurt more than any other brand I ever used. I have heard a lot of complaints about QV lately. Especially the 50ml bottles. One friend of mine actually developed a really large abscess using the 50ml bottle that we had to surgically open and wash it out. You should have seen what it looked like on the O.R. table. It was definately not good. Just be sure to watch your temp, and if it hits 100 or higher for more than a day you need to see a Dr and start some antibiotics. Just be careful and be smart.