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Anyone use T3 for speeding up protein synthesis???
- Thread starter MrRTTB
- Start date
Silent Method
New member
I'm thinking about it. Bump for ya.
Hugh Gellatts
New member
i've done 12.5mcg for that. you have to make sure to eat constantly for it to work at adding size. also i only do it when including tren and or 17aa orals....these seem to have a strong effect that counters any muscle loss from the t-3.
it does cut into water retention somewhat, so you won't see as big an instant "gain" off stuff like anadrol.
it does cut into water retention somewhat, so you won't see as big an instant "gain" off stuff like anadrol.
Unfortunately, it doesn't work. It's true that T3 increases protein synthesis. It's also true that T3 increases protein breakdown. The latter always wins out when you supplement with T3. Look at the graphs in figure 3 in this study:
http://jcem.endojournals.org/cgi/content/full/85/2/697#R11
The left graph shows protein breakdown as a function of administered T3. The right graph shows protein synthesis. The slope of the line in the left graph is steeper than in the right one. That means for a given T3 dose protein breakdown will always exceed synthesis.
The reason I linked to this study is that it demonstrates that insulin administration lowers the proteolytic effect of T3. The pros bulk with slin and burn fat at the same time with T3. The slin counteracts the catabolic effect of the T3.
Enigmaxxx7
New member
nandi12 said:
sweet. karma for u.
adoniscomplex
New member
Just pointing out that this study was only done on 6 people, who were hypothyroid in the first place, who were all around 48 years old, who were not on gear.
IMOH this is not a conclusaive study in relation to us as bodybuilders.
(just my opinion)
IMOH this is not a conclusaive study in relation to us as bodybuilders.
(just my opinion)
adoniscomplex
New member
I forgot to mention...
As of right now, I've been running anavar at 30mg a day for 36 days, with a low dose (25mcg) of t3 every morning. My weight pre-cycle was 174 lbs (5'6) and now I am up to a solid 185 lbs. (I weigh every day, first thing in the morning, on the same scale.)
I have to have to have lost at least one or two pounds of fat (my abs are MUCH better now than before the start of this cycle).
I feel I should point out that I am taking creratine with the var, so I'm sure that is where most of the weight is coming from, however, I feel as though this low dose of t3 has greatly improved my results on this cycle. I am eating small meals preety much every hour, on the hour, which I think is keeping my protein synthesis going full out.
My point is, I would recommend this low dose T3 method for I have gotten great results from it so far.
This is just my own opinion however, take it how you will.
adoniscomplex
As of right now, I've been running anavar at 30mg a day for 36 days, with a low dose (25mcg) of t3 every morning. My weight pre-cycle was 174 lbs (5'6) and now I am up to a solid 185 lbs. (I weigh every day, first thing in the morning, on the same scale.)
I have to have to have lost at least one or two pounds of fat (my abs are MUCH better now than before the start of this cycle).
I feel I should point out that I am taking creratine with the var, so I'm sure that is where most of the weight is coming from, however, I feel as though this low dose of t3 has greatly improved my results on this cycle. I am eating small meals preety much every hour, on the hour, which I think is keeping my protein synthesis going full out.
My point is, I would recommend this low dose T3 method for I have gotten great results from it so far.
This is just my own opinion however, take it how you will.
adoniscomplex
Anabolic steroids will also offset the catabolic effects of T3, but by a different mechanism Here is a link to a study I posted a while back about the combined effects of T3 and testosterone:
http://jcem.endojournals.org/cgi/content/full/84/1/207
They took two groups of men, gave one group 50 mcg/day of T3, and the other group got the same 50 mcg plus testosterone enanthate, 200mg/week. They were required to lie in bed for 28 days!
At the end of that period, the T3 group lost an average of 8.6lb, while the T3 + test group lost 2.2lb. Lean body mass in the T3 group declined by 3.3lb while the lean body mass of the T3 + test group increased by 4.4 lbs.
This is lying in bed on only 200mg/week of test, and probably on a poor (by bodybuilding standards) diet.
The group that carried out the insulin and T3 study also carried out another study, Adonis, (albeit again on just six people) under different conditions and arrived at the same conclusion: T3 increases the ability of insulin to inhibit proteolysis. They think this is an adaptive mechanism to reduce muscle wasting in hyperthyroidism:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7573427&dopt=Abstract
People also seem to adapt to T3 administration in that their nitrogen balance becomes less negative over time. See (1) and figure 2 in the paper linked to above:
http://jcem.endojournals.org/cgi/content/full/84/1/207
The group that carried out this and similar studies did not address the mechanism for this. Maybe it is the insulin effect described above.
(1) J Clin Endocrinol Metab 1997 Mar;82(3):765-70
A paradigm of experimentally induced mild hyperthyroidism: effects on nitrogen balance, body composition, and energy expenditure in healthy young men.
Lovejoy JC, Smith SR, Bray GA, DeLany JP, Rood JC, Gouvier D, Windhauser M, Ryan DH, Macchiavelli R, Tulley R.
dwilcox123
New member
does this mean a person who is using 300mg of Tren E and 300 mg of test E (and 50mg of proviron for free test/shbg inhibition) and 10 ius of gh eod could get a boost in protein synthesis from lets says 20mcg of t3 daily and some clen on the side would be in "total anti catabolic state with a higher protein synthesis?" btw i also take mirtazipine for sleep which also lowers cortisol levels...i know its alot but just curious
In a word - no.
it is a lot bro
step 1 is you shouldn't be using steroids if you have sleeping problems and you don't need to be taking a drug for sleep... you will NOT be able to get into stage 3/4 of sleep while on sleeping drugs, that is something your doctor WILL NOT tell you. so you are only hurting yourself
read the sleep article i wrote for evo
step 1 is you shouldn't be using steroids if you have sleeping problems and you don't need to be taking a drug for sleep... you will NOT be able to get into stage 3/4 of sleep while on sleeping drugs, that is something your doctor WILL NOT tell you. so you are only hurting yourself
read the sleep article i wrote for evo
I am not a fan of messing with your thyroid.
Me neither.
I think if anything it will have a negative impact on the protein synthesis.
