anyone know differences in these half-lifes?

[JKerry]

Ok, this is a bit off topic for this board, but being that I learned all I do about half life's on this board, I figured this would be the best place to ask my question. I'm currently using injectable corticosteroids for alopecia treatment and have run across two similar products for a desired effect. One being triamcinolone acetonide, which I'm currently using, and the next being triamcinolone hexacetonide. Does anyone know offhand or where I might be able to find the differences in half lifes between these two compounds??

triamcinolone acetonide
triamcinolone hexacetonide.

much thanks

 

[LVTitan]

never heard of either of these exact compounds, but just from looking at the names, i can tell you that the acetonide would need to be shot a lot more often than the hexacetonide.




that is, if they are anything like the esters used in gear. i dont want to sound like i know what i'm talking about, but that would be my observation.

 

[black sheep]

The most common agent currently used is methylprednisolone acetate (Depo-Medrol®), but Triacinolone acetonide (Kenalog®) and Triamcinolone hexacetonide (Aristospan®) are also used. These latter two agents have the advantage of greater half life. Commonly, a large joint such as a knee or shoulder would be injected with 40 mg (1 mL) of the methylprednisolone acetate solution

http://www.theberries.ns.ca/Archives/IA_therapies.html

 

[djsf]

From the finder/keeper of all knowledge, Google:

...Based upon intravenous dosing of triamcinolone acetonide phosphate ester in adults, the half-life of triamcinolone acetonide was reported to be 88 minutes...
http://www.rxlist.com/cgi/generic3/nasacort_aq_cp.htm

As for triamcinolone hexacetonide, all I could find is that it's half life is longer.