Musclehealth. I have never read in any legit publication about having receptor down- grade for AAS. (I hear people always talk about this idea and I do however read about it in shitty magazine articals...but I have yet too see proof) There are agents that may increase regulation. Many work by binding to protein globulin that would otherwise attach to the active drug and not let it work. Example if one of these is IGF-1 Binding Protein found in the human circulatory system.
There may be some other agents but I am not aware of any off the top of my head for the moment, that work at the receptor site and actually "amplify" the steriod....may methandriol? There are others like Stanzolol that lower the effect of SHBG...this isn't working at the receptor site either liek you asked about but it is still a good reason to use Stan products in many cycles.
Anyhow I am fairly certain you can't saturate thus causing receptor down regulation with anabolics.
If anyone has any documents showing down regulation please let me know..I have been searching for a while and am interested too.