Anti E ?? for Zyg

[biganth01]

Does Aromasin ( Exemestane ) lower you IGF 1 levels? Thanks in advance for any replys.

P.S. Anyone else not get email notification on thier posts,i click to be notified every time but never am!

 

[Nutrient-Nut]

In answer to your PS, yes. I never get an e-mail notification when someone replies to my threads. I use to, but now I don't, and I have everything set up correctly. I wonder if they don't allow non plat members to receive notification e-mails anymore?

NN

 

[hhajdo]

Abstract number: 143P
Citation: Annals of Oncology, Vol 11, Suppl.4 October 2000, page 34
Exemestane in post-menopausal patients failing treatment with non-steroidal structure aromatase inhibitors: Effects on insulin-like growth factor (IGF) components.
Antonia Martinetti2, Emilio Bajetta1, Luigi Celio1, Leonardo Ferrari2, Nicoletta Zilembo1, Paola Pozzi1, Roberto Buzzoni1, Ettore Seregni2, Emilio Bombardieri2, Ettore Bichisao3

1Unità Operativa Oncologia Medica B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy; 2Unità Operativa Medicina Nucleare, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy; 3I.T.M.O. Group, Milano, Italy


Background: It is known that several treatments for breast cancer influence growth factor circulating levels. In particular, we demonstrated that the post-menopausal advanced breast cancer treatment with letrozole, a non-steroidal structure aromatase inhibitor (NSS-AI), increases total IGF1 and IGF binding protein 3 (IGFBP3) serum levels. Aim of the study. We evaluated the effects of exemestane, a steroidal structure AI (SS-AI), on serum IGF1, IGF2 and IGFBP3 in post-menopausal patients (pts) failing NSS-AI treatment.
Material and methods: We studied 13 pts (median age 67 years, range 49-80) whose disease progressed under NSS-AI treatment (6 pts aminoglutethimide(Ag), 7 pts other NSS-AIs). Exemestane was administrated by oral route at the dose of 25 mg/day without wash-out from previous treatment. In case of progressive disease (PD), pts could be given exemestane at the highest dose of 100 mg/day. IGFs were quantitated by means of sensitive radioimmunoassays.
Results: The following table describes total (t) IGF1, tIGF2 and IGFBP3 median levels. Serum tIGF1 increased significantly (p=0.050, baseline vs. week 48), while tIGF2 and IGFBP3 levels showed no statistically significant variations. Both pts failing Ag and other NSS-AIs had the same behaviour.

Growth factor Baseline Week 8 Week 24 Week 48 PD Dose escalation
tIGF1 (ng/mL) 128.80 178.85 156.98 165.73 196.50 162.40
tIGF2 (µg/mL) 149.36 152.36 153.38 150.62 162.53 166.89
IGFBP3 (µg/mL) 4.72 5.12 5.57 4.22 5.01 4.27


Conclusions: This study demonstrates the SS-AI capacity of influencing IGF system components also when pts were previously treated with NSS-AIs. This may be explained considering that the two AI classes have different biological way of action.

 

[Zyglamail]

Does Aromasin ( Exemestane ) lower you IGF 1 levels? Thanks in advance for any replys.

In the simplest terms estrogen levels do have an effect of IGF-1 levels, the degree of effect seems to very a lot from person to person. You can find studies on all the popular anti-e'(ana, let and exe) that are contradictory to some degree so its real hard to tell. An example of what I mean is quoted below, granted its not directly related to IGF-1 but it does state ana had no impact on lipids which every one here seems to disagree with.

An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane.

Buzdar AU, Robertson JF, Eiermann W, Nabholtz JM.

Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA. [email protected]

BACKGROUND: The newer generation, nonsteroidal aromatase inhibitors (AIs) anastrozole and letrozole have shown superior efficacy compared with tamoxifen as first-line treatments and compared with megestrol acetate as second-line therapy in postmenopausal women with advanced breast carcinoma. In an open-label, Phase II trial, it was reported that exemestane showed numerical superiority compared with tamoxifen for objective response and clinical benefit. Because these agents ultimately may be administered for periods of up to 5 years in the adjuvant setting, it is of increasing importance to assess their tolerability and pharmacologic profiles. METHODS: In the absence of data from direct clinical comparisons, the published literature was reviewed for the clinical pharmacology, pharmacokinetic characteristics, and selectivity profiles of anastrozole, letrozole, and exemestane. RESULTS: At clinically administered doses, the plasma half-lives of anastrozole (1 mg once daily), letrozole (2.5 mg once daily), and exemestane (25 mg once daily) were 41-48 hours, 2-4 days, and 27 hours, respectively. The time to steady-state plasma levels was 7 days for both anastrozole and exemestane and 60 days for letrozole. Androgenic side effects have been reported only with exemestane. Anastrozole treatment had no impact on plasma lipid levels, whereas both letrozole and exemestane had an unfavorable effect on plasma lipid levels. In indirect comparisons, anastrozole showed the highest degree of selectivity compared with letrozole and exemestane in terms of a lack of effect on adrenosteroidogenesis. CONCLUSIONS: All three AIs demonstrated clinical efficacy over preexisting treatments. However, there were differences in terms of pharmacokinetics and effects on lipid levels and adrenosteroidogenesis. The long-term clinical significance of these differences remains to be elucidated. Copyright 2002 American Cancer Society.

P.S. Anyone else not get email notification on thier posts,i click to be notified every time but never am!

We mods dont really see the inner working of the beard so I cant be sure what the problem is with e-mail notification. If you are currently set up so your e-mail address used in profilce is an encrypted one, you may want to try a non-encrypted one and see if that works. I know there are issues with Vbulliten in regards to encrypted mail.

 

[biganth01]

Thanks for the input guys

 

[CanadianBro]

Every drug that inhibits the production or release of estrogen WILL have some sort of effect on IGF-1 levels.

As far as exactly how much is up for debate.

This is a question no one can answer with absolute certainty and accuracy.

One thing to keep in mind is that the length of therapy DEFINITELY affects IGF-1 levels and therefore none of the aromatase inhibitors (exe, let, ana) should be used for long periods of time.