With regards to acne, everyone will react differently and it is not always brought on by the same things in different individuals.
Some people get cystic acne on dbol while others don't get a spot. Some people are not affected by primo while others are. Acne in some individuals may be caused by an increase or higher levels of estrogen, but some people get acne on steroids that do not convert or aromatise.
I do know that I was on letro for a couple weeks and my joints started getting sore - I took 2 weeks off while also starting dbol and it came back fast and furious - cystic stuff - I started the letro again and within 4 days it started getting visibly better.
I am also washing and using several otc things.