Acne all you need to know.

[ryker77]

BENZAMYCIN

BENZAMYCIN
Company
Dermik

Pharmacologic Class
Macrolide antibiotic + antibacterial/keratolytic.

Generic Name
Benzoyl peroxide + Erythromycin

Available as
BENZAMYCIN JAR
(Erythromycin 3%, benzoyl peroxide 5%; gel)
BENZAMYCIN PAK
(Erythromycin 3%, benzoyl peroxide 5%; gel)

Indications
Acne vulgaris.

Adults
Apply to cleansed, dried areas twice daily.

Children
Not recommended.

Contraindications
Although not explicitly stated, hypersensitivity to this drug, to others in
ts class, to related drugs, or to any of its excipients, is assumed to be
a contraindication.

Precautions
Avoid eyes, mouth, mucous membranes.
Discontinue if excessive irritation or dryness occurs.
Pregnancy (Category C). Nursing mothers.

Interactions
Additive irritation with other topical agents.
PABA sunscreens may transiently discolor skin.

Adverse Reactions
Dryness, local reactions (eg, peeling, pruritus, burning sensation, erythema), superinfection; may bleach hair or fabrics.

How Supplied
Gel (jar, mix before dispensing)–23.3 g, 46.6 g
Pak (pouches, mixed by patient)–60

 

[ryker77]

BENZOYL PEROXIDE

BENZOYL PEROXIDE
Company
Various

Pharmacologic Class
Antibacterial/keratolytic.

Generic Name
Benzoyl peroxide

Available as
Benzoyl peroxide 5%, 10%; gel

Indications
Mild to moderate acne.

Adults
Apply sparingly to cleansed and dried area one or more times daily,
as tolerated.

Children
Not applicable.

Contraindications
Although not explicitly stated, hypersensitivity to this drug, to others in
its class, to related drugs, or to any of its excipients, is assumed to be
a contraindication.

Precautions
Avoid eyes, mouth, and mucous membranes.
Discontinue Gel if sever irritation occurs; discontinue Wash if itching, redness, burning, swelling, or undue dryness occurs.
May bleach fabrics or hair.
Pregnancy (Category C). Nursing mothers.

Interactions
PABA sunscreens may transiently discolor skin.

Adverse Reactions
Excessive dryness, allergic or contact dermatitis,
may bleach fabrics or hair.

How Supplied
Gel: 5%–45g
10%–45g, 90g

 

[ryker77]

CLEAR BY DESIGN

CLEAR BY DESIGN
Company
GSK Consumer

Pharmacologic Class
Antibacterial/keratolytic.

Generic Name
Benzoyl peroxide

Available as OTC
Benzoyl peroxide 2.5%; gel.

Indications
Acne.

Adults
Apply to cleansed, dry areas of face, neck, and body 1-2 times daily.

Children
Not applicable.

Contraindications
Although not explicitly stated, hypersensitivity to this drug, to others in
its class, to related drugs, or to any of its excipients, is assumed to be
a contraindication.

Precautions
Avoid eyes, mucous membranes.
Discontinue if excessive irritation, dryness occurs.

Adverse Reactions
Dry skin, pruritus, irritation.

How Supplied
Gel–1.5oz

 

[ryker77]

CLEOCIN T

CLEOCIN T
Company
Pharmacia

Pharmacologic Class
Lincosamide antibiotic

Generic Name
Clindamycin

Available as
Clindamycin (as phosphate) 1%; soln*; pads*; lotion; gel;
*(contains isopropyl alcohol 50%).

Indications
Acne vulgaris.

Adults
Apply thin film twice daily.

Children
Not recommended.

Contraindications
History of regional enteritis, ulcerative or antibiotic associated colitis.

Precautions
Avoid eyes, mouth, abraded skin and mucous membranes.
Atopic patients. Discontinue if significant diarrhea occurs.
Pregnancy (Category B). Nursing mothers.

Interactions
May potentiate neuromuscular blocking agents. Avoid erythromycin.

Adverse Reactions
Dryness, oily skin, burning, erythema, abdominal pain, gram (-) folliculitus, stinging eyes; rare: diarrhea, colitis.

How Supplied Plenty of options
Soln w. applicator–30mL, 60mL
Pledgets (1mL soln/pad)–60
Lotion–60mL
Gel–30g, 60g

 

[quadrat]

Topical green tea extract works great for acne...

Management of acne vulgaris with 2% polyphenone (green tea extract) in cream
a placebo-controlled, double-blind study.

T. Syed (1), A. Seyed (2)

(1) Department of Dermatology, University of California San Francisco, Box
0989, CA 94143, USA.
(2) Department of Chemistry, University of California at Berkeley, CA 94720,
USA.

Purpose

To evaluate the safety, tolerability and clinical efficacy of
Epigallocatechin gallate(-EGCg) 2% in cream to treat acne vulgaris.

Methods

Subjects (34M/26F), aged 12-30 years, harboring 10-150 mild-to-moderate,
open or closed comedones, including cystic acne lesions (mean 73) were
randomized into two parallel groups (active and placebo). The diagnosis of
acne vulgaris was established by clinical observations. Each patient
received an identical precoded tube (25g) with instructions on how to
topically apply the trial cream to the entire affected area of the acne
lesions, twice daily for 5 consecutive days per week. The study was
scheduled for 16 weeks with 6 weeks of active treatment. Absence of clinical
signs of acne lesions and inflammation was recorded as treated.

Results

By the end of the treatment 40.0% patients and 42.0% acnes were treated.
Breaking the code revealed, that 2% EGCg cream had cured 73.3% patients and
77.0% lesions, while placebo healed 6.6% patients and 6.7% acnes (2% EGCg
cream vs placebo; p<0.0001).

Conclusion

The findings of the study showed that along with non-objective mild side
effects, Green Tea Extract, (Polyphenone, -EGCg) 2% in cream is safe,
tolerable and significantly more effective than placebo to cure acne
vulgaris in young adolescents.

 

[ryker77]

CLINDAGEL

CLINDAGEL
Company
Galderma

Pharmacologic Class
Lincosamide antibiotic

Generic Name
Clindamycin

Available as
Clindamycin (as phosphate) 1%; gel.

Indications
Acne vulgaris.

Adults
Apply thin film once daily.

Children
Not recommended.

Contraindications
History of regional enteritis, ulcerative or antibiotic-associated colitis.

Precautions
Atopic patients. Discontinue if significant diarrhea occurs.
Pregnancy (Category B). Nursing mothers: not recommended.

Interactions
May potentiate neuromuscular blocking agents.

Adverse Reactions
Pruritus, peeling, abdominal pain, GI disturbances, gram (-) folliculitis; rare: diarrhea, colitis.

How Supplied
Gel–42 g, 77 g

 

[ryker77]

DESQUAM-X

DESQUAM-X
Company
Westwood Squibb

Pharmacologic Class
Antibacterial/keratolytic.

Generic Name
Benzoyl peroxide

Available as
Benzoyl peroxide 5%, 10%; water-base gel.

Indications
Mild to moderate acne.

Adults
Massage into cleansed area 1-2 times daily.

Children
Not applicable.

Contraindications
Although not explicitly stated, hypersensitivity to this drug, to others in its class, to related drugs, or to any of its excipients, is assumed to be a contraindication.

Precautions
Avoid eyes, mouth, mucous membranes. Pregnancy
(Category C). Nursing mothers.

Interactions
PABA sunscreens may transiently discolor skin.

Adverse Reactions
Excessive drying, allergic dermatitis, may bleach fabrics or hair.

How Supplied
Gel–1.5oz, 3oz

 

[ryker77]

DESQUAM-X WASH

DESQUAM-X WASH

Company
Westwood Squibb

Pharmacologic Class
Antibacterial/keratolytic.

Generic Name
Benzoyl peroxide

Available as
DESQUAM-X WASH
(Benzoyl peroxide 5%, 10%; water-base cleanser)
DESQUAM-X 10 BAR
(Benzoyl peroxide 10%)

Indications
Acne.

Adults
Bar: Wash for 1-2 minutes 2-3 times daily. Rinse well. Wash: Wet skin, apply, work to full lather, rinse and pat dry 1-2 times daily.

Children
Not applicable.

Contraindications
Although not explicitly stated, hypersensitivity to this drug, to others in its class, to related drugs, or to any of its excipients, is assumed to be a contraindication.

Precautions
Avoid eyes, mouth, mucous membranes. Pregnancy (Category C).
Nursing mothers.

Interactions
PABA sunscreens may transiently discolor skin.

Adverse Reactions
Excessive drying, allergic dermatitis, may bleach fabrics or hair.

How Supplied
Wash–5oz
Bar–3.75oz

 

[ryker77]

DIFFERIN

DIFFERIN
Company
Galderma

Pharmacologic Class
Retinoid.

Generic Name
Adapalene

Available as
DIFFERIN
(Adapalene 0.1%; gel; cream; alcohol-free)
DIFFERIN SOLUTION
(Adapalene 0.1%; soln; pads; contains alcohol 30%)

Indications
Acne vulgaris.

Adults
Apply to affected areas once daily, at bedtime,
after cleansing the area.

Children
Not recommended.

Contraindications
Although not explicitly stated, hypersensitivity to this drug, to others in
its class, to related drugs, or to any of its excipients, is assumed to be
a contraindication.

Precautions
Do not use on cuts, abrasions, or broken, eczematous, or sunburned skin. Avoid contact with eyes, lips, angles of the nose, mucous membranes. Minimize exposure to sun and UV light. Increased irritation in extreme weather (eg, wind, cold). Concomitant use of other topical irritants (see Interactions). Reduce frequency or discontinue if prolonged or severe irritation occurs. Pregnancy (Category C). Nursing mothers.

Interactions
Avoid use until the effects of sulfur, resorcinol, or salicylic acid have subsided. Increased irritation with other potentially irritating topical products (eg, medicated or abrasive soaps and cleansers, soaps
and cosmetics that have a strong drying effect, products with high concentrations of alcohol, astringents, spices, lime).
Avoid waxing treated areas.

Adverse Reactions
Erythema, scaling, dryness, pruritus, burning, acne flares.

How Supplied
Gel, cream–15g, 45g
Soln w. applicator–30mL
Pledgets, 1mL soln/pad–60

 

[ryker77]

DORYX

DORYX
Company
Warner Chilcott

Pharmacologic Class
Tetracycline antibiotic.

Generic Name
Doxycycline

Available as
Doxycycline (as hyclate) 75mg, 100mg; coated pellets in capsules.

Indications
Adjunct in severe acne.

Adults
100mg every 12 hrs for 1 day, then 100mg daily;
reduce dose after improvement. Take with fluids.

Children
Not applicable.

Contraindications
Although not explicitly stated, hypersensitivity to this drug, to others in
its class, to related drugs, or to any of its excipients, is assumed to be
a contraindication.

Precautions
Monitor blood, renal, and hepatic function in long-term use.
Sunlight or UV light. Pregnancy (Category D), Nursing mothers: Not recommended.

Interactions
May increase digoxin levels. Antacids, iron, zinc, calcium, magnesium, urinary alkalinizers reduce absorption. Avoid concomitant penicillins, methoxyflurane. Carbamazepine, hydantoins decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective.

Adverse Reactions
Photosensitivity, GI upset, rash, blood dyscrasias, hepatotoxicity.

How Supplied
Caps 75mg–60
100mg–50