I used it in 1997. I had light acne, but some of it was cystic so my doc prescribed it for me. I was clear until I did my first cycle (2000). My back, chest and shoulders have some, but my face has remained clear. I want to try this Isotrex, topical solution. It's the same isotretinoin in accutane but used topically. Since it is really only my back/shoulders and my middle chest I think this may be easier than dealing with all the sides from the pills.