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A DISTURBING study on Caffeine

Here's my understanding on caffeine. Caffeine mimics insulin, so even if your blood sugar is high your insulin level will be low. This will cause blood sugar (not insulin) levels to be high. As long as the blood glucose is properly disposed of (ALA will help this) then the sugar will not enter the cellular level causing stored energy, aka fat. Check out Animalbolics Diet. He has a good grasp on insulin. A few small meals composed of Protein, some complex carbs or fruit (apple) and a caffinated beverage early in the day to keep insulin down. Then carb and protein load after workout to boost insulin to send that protein to repair muscle. Also, insulin sensitivity is only decreased by the body constantly having to process simple sugars. I may not be completely right, but that's my understanding from lots of study on the topic.


"Caffeine mimics insulin... " I don't see how you arrive at this conclusion if caffeine lowers glucose uptake while insulin increases glucose uptake. The two have opposite effects. For example, caffeine mobilizes fatty acids, while insulin has the opposite effect.

"This will cause blood sugar (not insulin) levels to be high." Here the results of studies have been contradictory. Some show no change in insulin levels while others show an increase in insulin levels as a result of caffeine ingestion:

"In the caffeine trial the serum insulin and C peptide concentrations were significantly greater (P < or = 0.001) than for placebo for the last 90 min of the OGTT and the area under the curve (AUC) for both measures were 60 and 37% greater (P < or = 0.001), respectively. This prolonged, increased elevation in insulin did not result in a lower blood glucose level; in fact, the AUC for blood glucose was 24% greater (P = 0.20) in the caffeine treatment group. The data support our hypothesis that caffeine ingestion results in a greater increase in insulin concentration during an OGTT. This, together with a trend towards a greater rather than a more modest response in blood glucose, suggests that caffeine ingestion may have resulted in insulin resistance." (1)

"As long as the blood glucose is properly disposed of (ALA will help this) then the sugar will not enter the cellular level causing stored energy, aka fat." This is exactly what ALA does: it increases cellular uptake of glucose. If this glucose is not converted to glycogen or immediately used for energy it will be stored as fat.

" Also, insulin sensitivity is only decreased by the body constantly having to process simple sugars." People don't know how insulin resistance is caused. Sugar makes it worse but is not the cause. Insulin resistant individuals can totally eliminate simple sugars from the diet and still remain resistant. The cause of the insulin signalling and glucose transport defects are much more complex than just being caused by sugar.





(1) Can J Physiol Pharmacol 2001 Jul;79(7):559-65
Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test.
Graham TE, Sathasivam P, Rowland M, Marko N, Greer F, Battram D.
 
Low carb diets often aren't successful because when a person's carb intake drops below about 50 grams/day, the body cuts back on the conversion (so called deiodination) of T4 to T3 in an attempt to conserve energy. (T3 is the biologically active thyroid hormone.) Less T3 means a metabolic slowdown.

Ephedrine administration raises the T3 to T4 ratio probably due to increased deiodination (1). So when you take ECA or T3 on a ketogenic diet it really enhances fat loss.



(1) Am J Clin Nutr 1985 Jul;42(1):83-94
Enhanced thermogenic responsiveness during chronic ephedrine treatment in man.
Astrup A, Lundsgaard C, Madsen J, Christensen NJ.
 
I think the effects of caffeine are a little exaggerated here. Me, and almost everybody I know of, drinks a lot of Coffee, many consume ECA Stacks and had no problem building a lean muscular physique. The studies above were performed using only a few individuals, nothing was said about their regular use of Caffeine (maybe they chose men who claimed to not consume any Caffeine, cause a Study needs to show something!), nothing is said about long term effects, nothing about a tolerance the body builds up against Caffeine. Further, they gave the subjects a really good dose of Caffeine (5mg/kg bodyweight), which would be almost 500 mg´s of Caffeine for me. 500mg makes me feel quite uncomfortable (That´s about 5 cups of strong Coffee), only few consume that much caffeine.

I´m very sceptical about studies like that, performing tests on only two occasions, only seven subjects, using a VERY high dose of the drug.....

I´ll keep drinking my Coffee, fuck studies like that.
 
Here is what Bryan Haycock had to say about the insulin sensitivity/caffeine issue over at the HST board:

Caffein does temporarily decrease insulin sensitivity. So does anything else that is "lipolytic". I have read the study(s).

Exercise was shown to negate (reverse) the effect of the caffeine. This is because of what is called non-insulin dependant glucose uptake.

Anything that stimulates the release of noradrenaline or adrenaline will decrease insulin sensitivity. Even an increase in blood levels of released fatty acids will decrease insulin sensitivity. Its called the glucose fatty acid cycle, or the Randle Cycle. This is because the fat cell's "machinery" is not designed to store and release fuel at the same time. This would be counter productive. The only exception is exercise, where the body wants to release fuel from fat cells at the moment, but increase its ability to take in fuel to replace what it lost from muscle as fast as possible afterwards (or "during" exercise in the case of muscle tissue).

No need to panic about caffeine and insulin sensitivity. Its effects on insulin sensitivity have been known for a long time.
 
I think this is only significant immediately post work-out, when insulin sensitivity is most important.
 
I take 100-300mgs of green tea along with 500mgs ALA with every meal thats before 5:00pm. So I'd be taking 5 steps forward and about 2 back.

For every action there has to be an reaction!
 
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