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so i decided to start giving a run-down (the real nitty gritty, think of it as a cheat sheet) on the most used compounds in bodybuilding and the first compound i'm going to talk about is good ole Nolva.
Tamoxifen citrate is an orally available selective estrogen receptor modulator (SERM) known by the brand name Nolvadex made by AstraZeneca.
This means that it stimulates some estrogen receptors while blocking others.
For example, Tamoxifen blocks the estrogen receptors in breast tissue reducing the effect of the estrogen present in your body on that tissue (aka it stops gyno), however it is also an estrogen agonist (activates estrogen receptors) in certain tissues like bone and the liver which causes it to increase bone mineral density and improves cholesterol levels.
The good:
-blocks estro receptor in breast preventing gyno formation
-blocks estro receptor in hypothalamus helping kickstart natural test production during PCT
-improves cholesterol profile by acting as a "good" estrogen in the liver
-less liver toxicity & usually milder side effects than clomid with similar capacity to restart hpta & more effective on gyno
The bad:
-liver toxic
-lowers free test levels
-lowers igf-1
-can cause mood swings, irritability, anxiety, and low libido/erectile dysfunction
-increases clotting factors which increases risk for stroke & heart attack
-can cause visual anomalies (tracers) in some
-long half-life (5-7 days, which means that if you react poorly you'll have to wait a week or more for sides to subside)
Appropriate uses for tamoxifen:
#1) off-cycle gyno reduction - the only truly good use for tamoxifen, and this is usually over an extended course (weeks-months) and in combination with an AI and/or a DHT derived compound. even in this case raloxifene (evista) is a better choice if available.
#2) on-cycle gyno protection for anadrol (oxymetholone), anadrol's estrogenic effects cannot be controlled with an aromatase inhibitor because it does not aromatize. however oxymetholone is unique in that it is both an androgen and an estrogen at the same time and does not have to be aromatized to be estrogenic. therefore using arimidex, aromasin, or letrozole will have no effect on gyno from oxymetholone while tamoxifen will be effective.
#3) supplemental gyno protection - so let's say you're already running 1mg adex a day or letro or whatever your AI of choice is and the symptoms of gyno aren't subsiding? add 10-20mg tamoxifen per day and it should stop the gyno in its tracks
#4) PCT when you have limited choices. Tamoxifen is a tried and true PCT drug, not my first choice but given limited options it will successfully restart the HTPA in most cases, just be prepared to deal with the sides and know that you could have had a much smoother & safer pct.
inappropriate uses for tamoxifen:
#1) run throughout cycle to prevent any hint of gyno - a lot of guys will run nolva throughout at 10-20mg to "guarantee" they don't get gyno, this is poor practice not only because it hinders gains but because it's just not safe, tamox is liver toxic and increases clotting factors, and although it will help maintain a healthy lipid panel, if you are using aromatizing AAS and eating clean your lipids should not be that skewed anyways and you may actually be increasing your risk for stroke/heart attack
#2) first line defense against gyno, nolva should be one of your last lines of defense for gyno protection
#3) pct when better options are available.
anyways, what do you guys think of this evaluation? (i bet nelson agrees with me, lol)
i plan to do a write up like this for every major compound used
Tamoxifen citrate is an orally available selective estrogen receptor modulator (SERM) known by the brand name Nolvadex made by AstraZeneca.
This means that it stimulates some estrogen receptors while blocking others.
For example, Tamoxifen blocks the estrogen receptors in breast tissue reducing the effect of the estrogen present in your body on that tissue (aka it stops gyno), however it is also an estrogen agonist (activates estrogen receptors) in certain tissues like bone and the liver which causes it to increase bone mineral density and improves cholesterol levels.
The good:
-blocks estro receptor in breast preventing gyno formation
-blocks estro receptor in hypothalamus helping kickstart natural test production during PCT
-improves cholesterol profile by acting as a "good" estrogen in the liver
-less liver toxicity & usually milder side effects than clomid with similar capacity to restart hpta & more effective on gyno
The bad:
-liver toxic
-lowers free test levels
-lowers igf-1
-can cause mood swings, irritability, anxiety, and low libido/erectile dysfunction
-increases clotting factors which increases risk for stroke & heart attack
-can cause visual anomalies (tracers) in some
-long half-life (5-7 days, which means that if you react poorly you'll have to wait a week or more for sides to subside)
Appropriate uses for tamoxifen:
#1) off-cycle gyno reduction - the only truly good use for tamoxifen, and this is usually over an extended course (weeks-months) and in combination with an AI and/or a DHT derived compound. even in this case raloxifene (evista) is a better choice if available.
#2) on-cycle gyno protection for anadrol (oxymetholone), anadrol's estrogenic effects cannot be controlled with an aromatase inhibitor because it does not aromatize. however oxymetholone is unique in that it is both an androgen and an estrogen at the same time and does not have to be aromatized to be estrogenic. therefore using arimidex, aromasin, or letrozole will have no effect on gyno from oxymetholone while tamoxifen will be effective.
#3) supplemental gyno protection - so let's say you're already running 1mg adex a day or letro or whatever your AI of choice is and the symptoms of gyno aren't subsiding? add 10-20mg tamoxifen per day and it should stop the gyno in its tracks
#4) PCT when you have limited choices. Tamoxifen is a tried and true PCT drug, not my first choice but given limited options it will successfully restart the HTPA in most cases, just be prepared to deal with the sides and know that you could have had a much smoother & safer pct.
inappropriate uses for tamoxifen:
#1) run throughout cycle to prevent any hint of gyno - a lot of guys will run nolva throughout at 10-20mg to "guarantee" they don't get gyno, this is poor practice not only because it hinders gains but because it's just not safe, tamox is liver toxic and increases clotting factors, and although it will help maintain a healthy lipid panel, if you are using aromatizing AAS and eating clean your lipids should not be that skewed anyways and you may actually be increasing your risk for stroke/heart attack
#2) first line defense against gyno, nolva should be one of your last lines of defense for gyno protection
#3) pct when better options are available.
anyways, what do you guys think of this evaluation? (i bet nelson agrees with me, lol)
i plan to do a write up like this for every major compound used
