darwinmcduck
New member
I have heard that it will stop its progression but will it reverse the puffiness?-
Zuperman said:^^^^^^^^^^^^^^^^^It did it once, And now its doing it again!!
d1s0rd3r said:I am 20 and have puffy nipples since 13.
I will try that combo, but will the puffyness comeback after the end of the therapy?
Tallguy1 said:I did my first cycle recently of just test and didn't use a AI.. I started to get sore nipples in week 9 or 10... letro + nolva cured it.
I am going to do a 2nd cycle soon of test + EQ... this time I want to make sure I use an AI.. can I do .25/EOD of letro without it adversely affecting my gains?
Mr.X said:how much test are you using?
Mr.X said:how much test are you using?
Mr.X said:That's a hormonal rebound, it happens to some people. The point is that the combo did get rid of your gynecomastia, and very effectively if I might add.![]()
i am one of those peopleMr.X said:For a lot of people the letrozole + nolvadex combo is very effective at reversing gynecomastia.
Tallguy1 said:What do you think Mr.X, is that dosage of Femera - letrozole - sufficient?
I had a nice hard lump, I added letrozle and it is now about 80% gone, and it was a pretty SOLID lump.Nelson Montana said:Any anti e may reverse estrogenic symptoms such as puffy nips but will unlikly remove a hard lump -- except for Nolvaldex - tamoxifen citrate - , which is one of the few things it's good for.
blackpanther said:Sounds great Legacy! I have heard similar plans to the one you suggested, only that the doses of Femara/Letrozole have been literally 5 X higher per day!! (2.5 mg/day)
2 questions then...
1) Do you think the 2.5 mg recommendation is way overkill?
2) I find from all the readings of old posts and findings on the internet, you get about a 50/50 split. Half of the people say the Femera - letrozole - will work great for them and destroyed old gynocomastia tissue they had. Whereas for the other half, surgery was the only option. The question is: At what point in the Femera - letrozole - treatment do you start actually seeing/feeling a difference? (2-3 weeks into it??) Or, at what point do you just throw in the towel and realize it is not going to work for you??
Thanks so much for any replies....![]()
FISHTALES said:i am one of those people
Mac173 said:The thing w/ gynecomastia is to NIP it in the bud.
blackpanther said:Is there any benefit to running the Femera - letrozole - with the Nolvaldex - tamoxifen citrate - at the same time? Or do you save Nolva for afterwards to prevent any type of "estrogen rebound?"
I have read conflicting things.... Some say the combo is synergistic when used together. Others say that Nolva can interfere with plasma concentrations of Letro, making it less potent and to only use it FOLLOWING the Femera - letrozole - . I don't know what to make of all this...
So yea the question is:
Letro alone until the gynecomastia dies off (followed by an extra week just in case) and then follow it with Nolva?
Or run them at the same time?
Somebody got it.socket said:No pun intended!!!
Femara works a treat if you get it early. keep dosages as low as possible to avoid other issues.
st8grad said:Don't run them at the same time. Nolvadexx will reduce the efficacy of Femmera.
ddwmvp said:I developed hard lumps behind my nipples when I was 12 years old. I've had puffy nipples ever since. I am now 30 years old. This has haunted me my entire life. Its so embarrassing. I am now going to begin my first cycle. I have been learning about cycles and this is when I learned about letrozole. I have never been so excited to read that this might reverse the gyno in my nipples. I have to give it a shot. I knew I could have surgery to remove the lumps but never really had the money and was not to sure if thats what i wanted. My question is...i have a bottle of letrozole and it reads 30ml/2.5mg/ml. I guess this means each drop is 2.5mg. What if I want to take less than that? And does anyone know how much I should be taking in an effort to get rid of these puffy nipples that have plagued me for 18 years?
darwinmcduck said:I have heard that it will stop its progression but will it reverse the puffiness?-
JHarhay said:I have had gynecomastia since i was about 13 and im 19 now.. i am taking 2.5mg/day and i have seen improvement in the lumps but the puffiness is not going away....i lift but take no supplements that would make this condition worse... anyone know how to take care of this..
Since it's not AAS-related, you REALLY ought to see an endocrinologist rather than trying to self-medicate. Men can get breast cancer, you know; all the parts are there, it's just that they are (usually) dormant.JHarhay said:I have had gynecomastia since i was about 13 and im 19 now.. i am taking 2.5mg/day and i have seen improvement in the lumps but the puffiness is not going away....i lift but take no supplements that would make this condition worse... anyone know how to take care of this..
digger said:Since it's not AAS-related, you REALLY ought to see an endocrinologist rather than trying to self-medicate. Men can get breast cancer, you know; all the parts are there, it's just that they are (usually) dormant.
hi djlegacy,To first understand why you are doing what you are doing I am going to go over a few things and a few definitions:
SERM – Selective estrogen receptor modulator. These drugs work by binding to the estrogen receptors and flooding them in a sense, making it difficult (but not impossible by any means) for estrogen to bind to the receptors and thus prevent the onset of estrogen related side effects.
Most common forms: Tamoxifen (Nolvadex), Clomiphene (Clomid)
AI – Aromatise Inhibitor. These drugs work by inhibiting the aromatization of estrogen. This means that in effect AI’s prevent androgens from converting to estrogen, again, making it difficult (but not impossible) for estrogen to reach receptor sites.
Most common forms: Anastrozole (l-dex, a-dex), Exemestane (aromasin), Femera (letrozole). For our purpose of reversing gyno we are interested in Letro.
Letro and your sex drive:
Letrozole will suppress your sex drive. This is another reason why it is so important to act on preventing gyno as soon as possible. Since we all know that Test should be run in every cycle this will cancel out the effect of sex drive suppression.
Running letro to prevent gyno:
If you decide to run estrogen protection while on cycle (and I suggest you do unless you are aware that you do not require it), you can run either a SERM or an AI. Letro will be the most powerful AI you can use, it will inhibit 98+% of estrogen using a dose as low as .25mg and even lower. This is why I suggest you do not use a dose higher than .50mg while on cycle just trying to prevent estrogen related side effects.
You will want to start running the letro approximately 2 weeks before you begin your cycle to allow it to fully stabilize in your blood. I have often heard the argument that letro takes up to 60 days to stabilize, I don’t know if I buy into this for the reason that I have reversed gyno after using letro for only 1 week. Still to be safe I recommend starting it before your cycle as stated above.
If you do decide to run letro there is absolutely no need to run another AI or SERM. Do not make the mistake of thinking more is better. Think of it this way; if letro is preventing the conversion of androgens to estrogen than there is no estrogen, what would the purpose of a SERM be when there is no estrogen to bind to the receptors? Nolva will only take away from the effectiveness of letro.
This brings me to my next point. Do not listen to anyone who tells you to bump up your nolvadex to 60+mg ED if you get gyno. I have no idea where this idea started but I have seen it suggest far too many times recently. Nolvadex will do nothing to reverse your gyno…let me make that clear IT WILL DO NOTHING FOR GYNO. If you are running nolva as your anti-e and start to develop gyno than sure you can bump the dosage a small amount to try to prevent it from progressing further, but letrozole must begin ASAP.
It is very important that you begin taking letrozole immediately, the longer your wait the more risk you take in not being able to reverse it.
How do I know if I have gyno?
If you have developed gyno you will have a lump behind your nipple. It will be fairly hard, and it will be tender to touch.
Running letro to reverse gyno:
I am going to go over the three different scenarios which people could fit into. Remember regardless of what scenario you are in it is important that you begin taking the letro ASAP.
1. Already using an anti-e aside from letro.
2. Already using letro @ a dose of .25mg or .50mg ED.
3. Not running any estrogen protection.
1.
Day 1: .25mg Letro + anti-e*
Day 2: .50mg Letro
Day 3: 1.0mg Letro
Day 4: 1.5mg Letro
Day 5: 2.0mg Letro
Day 6: 2.5mg Letro **
2.
Day 1: .50mg Letro
Day 2: 1.0mg Letro
Day 3: 1.5mg Letro
Day 4: 2.0mg Letro
Day 5: 2.5mg Letro **
3.
Day 1: .50mg Letro
Day 2: 1.0mg Letro
Day 3: 1.5mg Letro
Day 4: 2.0mg Letro
Day 5: 2.5mg Letro **
*Regardless of the anti-e you are using it is important to still use it for the first day you begin letro as the letro will not have taken any effect and you by no means want your body to be without any protection when gyno is already prevalent.
** You will remain at this dose until gyno symptoms subside. Once you believe your gyno is gone it is important to stay at this dose for another 4-7 days to ensure all traces are gone. I recommend people with a bf% over 15 stay on for a week as it may be harder to judge completely whether the lump is completely gone. Once this period is over it will be important to taper letro down slowly rather than coming off it completely. Regardless of which manner you tapered up your dose you will all taper down in the same fashion.
Day 1: 2.0mg
Day 2: 1.5mg
Day 3: 1.0mg
Day 4: .50mg***
Day 5: .25mg
***You can remain at this dose or go down further to .25mg. It is really up to you at this point. They are both very common maintenance doses as an anti-e while on cycle. Personally I have stayed with .25mg and never had a problem.
Letro and the estrogen rebound:
With your estrogen being completely inhibited there is a definite estrogen rebound as your body tries to re-stabilize the testosterone:estrogen balance. We can prevent this rebound effect by supplementing further with another AI or SERM. So, I suggest that when you are coming to the end of your cycle you will more than likely be using Nolva in your PCT so just make sure that you begin taking nolva the last day you are going to take your letro and then continue on as you would with regular PCT.
This now leads us into the question of reversing gyno while not on cycle. There are a few things to remember here. You have already waited longer than you should have, and your sex drive will be shot. You can use tribulus or another natural test booster to help you in this scenario but I can’t guarantee the effectiveness. Just follow gyno reversal protocols 2 or 3. When coming off again you must taper and begin using nolvadex to prevent any rebound effect that may occur.
How much nolvadex should you use if you are not going into PCT and running this off cycle? I suggest starting at 20mg ED for a week and then lowering it to 10mg for another week and then coming off completely.
I hope this covers most of the issues, still feel free to PM me if you have questions. But make sure you read the entire post first.
Hey are there any suggestions for me or should I follow what you wrote in the post. I just asked a question in the forum last nighthi djlegacy,
I had realy high level of estradiol. But since I started to take letro my estradiol lowered to 37 from 130 pg/ml. I am happy with the result. I took 2.5 mg daily for the last 19 days. I am guessing the dose I have been taking is too high. Do you think I should take only once a week a 2.5 mg letro?
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