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your thought on igf long3
- Thread starter marcu_s
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RADAR
Well-known member
IGF Long3 was developed to substitute insulin as a growth promotor to cell lines in TISSUE CULTURE. These cells in have (like most cell types) IGF-1 receptors on there cell surface. But the can also secrete into the media IGF-1 binding proteins. Some, like IGF1 binding protein 4 for instance, DOWNREGULATE the effect of IGF-1. As a growth additive in tissue culture you do not really want any up or down regulatory effects because this throws up variables that will sway the results of experiments. Hence the addition of the 18 aa residue in IGF-1 Long three. It wil happily interact wih the cells (via their receptors) in tissue culture without being subjected to the vagaries of any secreted binding proteins.
But remember that in tissue culture we are just dealing with , for example , a monolayer of muscle cells. the majority of IGF-1 is produced in the liver. In order to get out of the liver it HAS to bind to a cell surface IGF-1 binding protein (IGF-1 BP-2) which actively shuttles it from this tissue to the bloodstream. (unlike fat soluble steroids IGF-1 is to big a molecule to just pass through cell menbranes without being the aid of transmembrane proteins. Once in the the blood stream IGF-1 is normally bound by a secretory binding protein (BP-3). This is a larege molecule whose role would appear to envelope the IGF-1 molecules and proect it from brakdown by proteases as it flows through the blood to target tissues.To then get into a tissue such as muscle. It must first be donated back to binding protein 2 for mebrane tranlocation. Once in the muscle the activity of the IGF1 is upregulated (bp-5) or downregulated (bp-4) by other binding proteins. Although once inside the tissue it does not need to be bound to BP's to elicit a response.Science has come a long way!
But remember that in tissue culture we are just dealing with , for example , a monolayer of muscle cells. the majority of IGF-1 is produced in the liver. In order to get out of the liver it HAS to bind to a cell surface IGF-1 binding protein (IGF-1 BP-2) which actively shuttles it from this tissue to the bloodstream. (unlike fat soluble steroids IGF-1 is to big a molecule to just pass through cell menbranes without being the aid of transmembrane proteins. Once in the the blood stream IGF-1 is normally bound by a secretory binding protein (BP-3). This is a larege molecule whose role would appear to envelope the IGF-1 molecules and proect it from brakdown by proteases as it flows through the blood to target tissues.To then get into a tissue such as muscle. It must first be donated back to binding protein 2 for mebrane tranlocation. Once in the muscle the activity of the IGF1 is upregulated (bp-5) or downregulated (bp-4) by other binding proteins. Although once inside the tissue it does not need to be bound to BP's to elicit a response.Science has come a long way!
Wow that is a lot of IGF. How long do you run that for?
I usually just get 5000mcg and use it up in about 4 weeks and then take 4 or so weeks off.
Ive done 1000mcg in one administration before split into 20 bilateral 50mcg shots into every muscle along with 200grams caarbs. My whole body got a pumped/tingly feeling that lasted for a bout a week. I think this is a good way to do igf1 also if this is only done once or so a month. I felt like i was growing, hard to explain feeling.
Para_Shoot
New member
^^^^ Way too much.
eClenbuterol
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some of these dosages are insane
i think he is mixed up with HCG no way anyone would take that much IGF, or he is thinking of MGC or some other peptide. Or he is buying the cheapest most worthless IGF known to man kind, or its just fake.
No im not mixing it up with anything. 120mcg/day is not an insane dose. 1000mcg at once is insane but i just wanted to see what happens and IMO was worth it. Im using very good quality igf-1.
I post my high dosage experiences just to let people know what happens and because i find it very interesting how the body reacts to high dosages.
Para_Shoot
New member
Some people should not play with research chems..
jacshelb
New member
A lot of guys use higher doses like that, not so uncommon. It's just the current trend to go the absolute minimum route with igf. I've heard a lot of bigger guys say they use it this way (75-125 mcg/day) Personally I'm trying 40 mcg pre or post workout (still figuring out what works best) 3 x week. Some say they don't see anything with less than 60 or 75 mcg/day. But, I agree that seems high. To each their own.
Oh I must have miss-read your statement, I thought you often used 1,000mcg's. LOL
No 120 every day is not insane, just increasing ur risk. For me less than 100mcg's x 3 week works great for me. We are all different and if you know what the sides are and you monitor yourself constantly than GLTY!
No 120 every day is not insane, just increasing ur risk. For me less than 100mcg's x 3 week works great for me. We are all different and if you know what the sides are and you monitor yourself constantly than GLTY!
builtbychevy
New member
Personally I prefer Trenbolone which is known to increase IGF's... I like to stick with something known to perform...
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