yohimbe

[tazmo]

Could anyone tell me a good place to buy yohimbe.Thanks

 

[Par Deus]

TwinLabs makes a good yohimbe product -- though Yohimbine HCl tends to produce less side effects than herbal yohimbe.

 

[BigEasy]

Yes, click on the supplements link on the banner at the top of the page.

Or you could go to a US WalMart and buy TwinLab Yohimbe Fuel.

BE

P.S. Mods: Delete this if it is considered a 'source post'

 

[HappyScrappy]

if you want yohimbine hcl orally, I only know of non-legal ways of obtaining it.
if you want it in a powder to topical administration, then you can get it from the AF store (do a search for the link). although it seems expensive to me there.
I got some of their stuff, and I started topical administration last night with aloe vera gel from banna boat since that was what I had on hand and macro said that was okay.
not really sure how much to use - I just took the scoop that it came with and rubbed on coop on each "love handle" and lower back and also around my belly button.

not sure how long before I'll see results, but I would definitely assume longer than a day.

 

[tripleV]

HappyScrappy...just interested in seeing if you got any effects from the topical yohminbe.
Anyone...what do you see as the benefits of Yohimbe?
Thanks

 

[Par Deus]

Anyone...what do you see as the benefits of Yohimbe?
Thanks

The following pertains to yohimbine, but is fairly applicable to yohimbe:


One of the major contributors to body weight homeostasis in the human body is the sympathetic nervous system, the principal components of which are the catecholamines (epinephrine and norepinephrine) and the andrenergic receptors. There are two types of adrenergic receptors, alpha and beta, as well as subtypes of each -- and depending on which are activated, lipolysis (breakdown of fat) can be either stimulated or inhibited.

The most well-known adrenoreceptors to bodybuilders are the beta receptors. These can be divided into subtypes 1, 2, and 3 -- and it is through these receptors that drugs such as the ephedrine/caffeine stack and Clenbuterol exert their effects. While Clenbuterol acts directly on beta 2 receptors, ephedrine exerts its effects indirectly by stimulating the release of norepinephrine (NE), the body's primary endogenous thermogenic hormone. Unlike Clenbuterol, NE is not selective in its binding. In addition to binding to the beta 2 receptor, it also binds to both alpha receptors, as well as the beta 1 and 3 receptors. It is in regards to its binding to the alpha 2 receptor that yohimbine comes into play.

Norepinephrine and Yohimbine

Activation of the alpha 2 receptor inhibits the release of NE. Thus, by binding to this receptor, NE functions as its own negative feedback signal. In other words, it shuts off its own release. Obviously, this is not a good thing for fat loss. This is particularly true at rest (which, unless you are a marathon runner is 95% of your day) -- this is because alpha 2 receptors are activated at lower catecholamine levels than are the beta receptors (1). Thus, thermogenesis is basically always turned off. It is the differences in regional distribution of alpha 2 and the beta receptors that is responsible for the gender differences in bodyfat storage (2). Basically, females have a large number of alpha 2 receptors and few beta receptors in the gluteofemoral area (hips, thighs, and butt), while men have the same problem in the midsection. With exercise or the use of compounds such as the ephedrine/caffeine stack, catecholamine levels can be increased to a point where the alpha 2 induced inhibition of lipolysis is partially overcome (1). However, even then, the alpha 2 receptors ARE still acting to reduce lipolysis. Yohimbine is a selective alpha 2 antagonist (3) and can thus short circuit this feedback loop, maximizing NE levels, thus maximizing fat loss, particularly in these problem areas.

Blood Flow

A second, more indirect, mechanism by which Yohimbine can aid lipolysis via the adrenergic system is by increasing peripheral blood flow (4, 5). Adipose tissue is known to have rather poor vascularity. When triglycerides are broken down into free fatty acids and glycerol during lipolysis, they must also be transported away from the fat cell or they risk being reincorporated into adipose tissue. Beta receptor activation causes vasodilation, thus increasing blood flow, however, it does not increase enough to remove all of the free fatty acids released during lipolysis (6). Alpha 1 and 2 receptor activation, on the other hand, causes a decrease in blood flow (2, 7). Thus, antagonism of the alpha 2 receptor with yohimbine would be expected to increase blood flow, and thus increase the mobilization and disposal of these FFA's, further aiding fat loss.


1. Arner P, Kriegholm E, et al. Adrenergic regulation of lipolysis in situ at rest and during exercise. J Clinical Invest 1990; 85:893-898.

2. Millet L, Barbe M, Lafontan M, Berlan M, Galitzky J. Catecholamine effects on lipolysis and blood flow in human abdominal and femoral adipose tissue. J Appl Physiol 1998; 85(1):181-188.

3. Goldberg MR Robertson D. Yohimbine: a pharmacological probe for study of the a 2-adrenoceptor. Pharmacol Rev 1983;35:143-180.

4. Berlan M, Galitzky J, Riviere D, et al. Plasma catecholamine levels and lipid mobilization induced by yohimbine in obese and non-obese women. Int J Obesity 1991; 15:305-315.

5. Galitzky J, Taouis M, Berlan M, Riviere D, et al. a 2-Antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect oral yohimbine in healthy male volunteers. Eur J Clin Invest 1988; 18:587-594.

6. Hodgetts V, Coppack S, Frayn KN, Hockaday TDR. Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. J Appl Phys 1991; 71:445-451.

7. Ruffolo RR, Bondinell W, Hieble JP. a - and b -Adrenoceptors: From the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem 1995; 38(19):3415-3444.